The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms
Abstract Background Genetic variation in the gene ALOX5AP , encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenes...
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| Veröffentlicht in: | Atherosclerosis 2012-02, Vol.220 (2), p.425-428 |
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| creator | Bisoendial, Radjesh J Tanck, Michael W Golledge, Jonathan Broekhuizen, Lysette N Legemate, Dink A Stroes, Erik S.G Norman, Paul E |
| description | Abstract Background Genetic variation in the gene ALOX5AP , encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA). Methods and results The association of the ALOX5AP haplotypes with AAA was assessed in a large population-based cohort of 613 men aged ≥65 years with screen-detected AAAs and 707 randomly selected age-matched controls without AAA. Taqman assays were used to assess seven previously described single nucleotide polymorphisms (SNPs) of ALOX5AP . Haplotypes A and B were defined by the four SNPs (SG13S25, SG13S114, SG13S89, SG13S32) and (SG13S377, SG13S114, SG13S41, SG13S35), respectively. After adjustment for cardiovascular risk factors, there were no significant differences in the distribution of ALOX5AP haplotypes between cases and controls. Conclusion A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA. |
| doi_str_mv | 10.1016/j.atherosclerosis.2011.10.040 |
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Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA). Methods and results The association of the ALOX5AP haplotypes with AAA was assessed in a large population-based cohort of 613 men aged ≥65 years with screen-detected AAAs and 707 randomly selected age-matched controls without AAA. Taqman assays were used to assess seven previously described single nucleotide polymorphisms (SNPs) of ALOX5AP . Haplotypes A and B were defined by the four SNPs (SG13S25, SG13S114, SG13S89, SG13S32) and (SG13S377, SG13S114, SG13S41, SG13S35), respectively. After adjustment for cardiovascular risk factors, there were no significant differences in the distribution of ALOX5AP haplotypes between cases and controls. Conclusion A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2011.10.040</identifier><identifier>PMID: 22129473</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>5-Lipoxygenase activating protein ; 5-Lipoxygenase-Activating Proteins - genetics ; Aged ; aneurysm ; Aneurysm formation ; Aortic Aneurysm, Abdominal - genetics ; Aortic Aneurysm, Abdominal - pathology ; arachidonic acid ; atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular ; Case-Control Studies ; Chi-Square Distribution ; Diseases of the aorta ; gene expression regulation ; Gene Frequency ; genes ; Genetic Predisposition to Disease ; genetic variation ; Haplotypes ; Humans ; Inflammation ; Leukotrienes ; Male ; Medical sciences ; men ; myocardial infarction ; Netherlands ; Odds Ratio ; pathogenesis ; Phenotype ; Polymorphism, Single Nucleotide ; risk ; Risk Assessment ; Risk Factors ; single nucleotide polymorphism ; stroke</subject><ispartof>Atherosclerosis, 2012-02, Vol.220 (2), p.425-428</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-ab13e314a652d26294af758723f249e314f00feff52807ffd85f62f78b3284ad3</citedby><cites>FETCH-LOGICAL-c497t-ab13e314a652d26294af758723f249e314f00feff52807ffd85f62f78b3284ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915011010641$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25455014$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22129473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bisoendial, Radjesh J</creatorcontrib><creatorcontrib>Tanck, Michael W</creatorcontrib><creatorcontrib>Golledge, Jonathan</creatorcontrib><creatorcontrib>Broekhuizen, Lysette N</creatorcontrib><creatorcontrib>Legemate, Dink A</creatorcontrib><creatorcontrib>Stroes, Erik S.G</creatorcontrib><creatorcontrib>Norman, Paul E</creatorcontrib><title>The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Background Genetic variation in the gene ALOX5AP , encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA). Methods and results The association of the ALOX5AP haplotypes with AAA was assessed in a large population-based cohort of 613 men aged ≥65 years with screen-detected AAAs and 707 randomly selected age-matched controls without AAA. Taqman assays were used to assess seven previously described single nucleotide polymorphisms (SNPs) of ALOX5AP . Haplotypes A and B were defined by the four SNPs (SG13S25, SG13S114, SG13S89, SG13S32) and (SG13S377, SG13S114, SG13S41, SG13S35), respectively. After adjustment for cardiovascular risk factors, there were no significant differences in the distribution of ALOX5AP haplotypes between cases and controls. Conclusion A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA.</description><subject>5-Lipoxygenase activating protein</subject><subject>5-Lipoxygenase-Activating Proteins - genetics</subject><subject>Aged</subject><subject>aneurysm</subject><subject>Aneurysm formation</subject><subject>Aortic Aneurysm, Abdominal - genetics</subject><subject>Aortic Aneurysm, Abdominal - pathology</subject><subject>arachidonic acid</subject><subject>atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Diseases of the aorta</subject><subject>gene expression regulation</subject><subject>Gene Frequency</subject><subject>genes</subject><subject>Genetic Predisposition to Disease</subject><subject>genetic variation</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukotrienes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>men</subject><subject>myocardial infarction</subject><subject>Netherlands</subject><subject>Odds Ratio</subject><subject>pathogenesis</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>single nucleotide polymorphism</subject><subject>stroke</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkFv1DAQhS0EokvhL0AuFacstmPHzgEkVEFBqsSh7dlynPHWIYkXOynsv2eiXXroiYsteb558_TGhFwwumWU1R_6rZ3vIcXshvUMecspY1jbUkGfkQ3TqimZ0OI52VDKWdkwSc_Iq5x7SqlQTL8kZ5wz3ghVbUh_ew-FzTm6YOcQp6KF-TfAVOCQYgcTFDC52IVpV8hyCPv454CvNmOTm8MD9mBln-IMYSrs1BW27eIYJjsUNqY5OHyEJR3ymF-TF94OGd6c7nNy9_XL7eW38vrH1ffLz9elE42aS9uyCiombC15x2v0ab2SWvHKc9GsFU-pB-8l11R532npa-6Vbiuuhe2qc_L-qIu2fi2QZzOG7GAY0ElcsmmYkkor2iD58Ug6TDIn8GafwmjTwTBq1rRNb56kbda01zKmjf1vT5OWdoTusftfvAhcnACbnR18spNDjUdOCikpE8i9O3LeRmN3CZm7G5wk15VpoVelqyMBmNxDgGSyC7ga6EICN5suhv82_emJkhvCFNDeTzhA7uOScHvZMJO5oeZm_UTrH2KoTWvBqr8a28bn</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Bisoendial, Radjesh J</creator><creator>Tanck, Michael W</creator><creator>Golledge, Jonathan</creator><creator>Broekhuizen, Lysette N</creator><creator>Legemate, Dink A</creator><creator>Stroes, Erik S.G</creator><creator>Norman, Paul E</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms</title><author>Bisoendial, Radjesh J ; Tanck, Michael W ; Golledge, Jonathan ; Broekhuizen, Lysette N ; Legemate, Dink A ; Stroes, Erik S.G ; Norman, Paul E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-ab13e314a652d26294af758723f249e314f00feff52807ffd85f62f78b3284ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>5-Lipoxygenase activating protein</topic><topic>5-Lipoxygenase-Activating Proteins - genetics</topic><topic>Aged</topic><topic>aneurysm</topic><topic>Aneurysm formation</topic><topic>Aortic Aneurysm, Abdominal - genetics</topic><topic>Aortic Aneurysm, Abdominal - pathology</topic><topic>arachidonic acid</topic><topic>atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Diseases of the aorta</topic><topic>gene expression regulation</topic><topic>Gene Frequency</topic><topic>genes</topic><topic>Genetic Predisposition to Disease</topic><topic>genetic variation</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukotrienes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>men</topic><topic>myocardial infarction</topic><topic>Netherlands</topic><topic>Odds Ratio</topic><topic>pathogenesis</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>risk</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>single nucleotide polymorphism</topic><topic>stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bisoendial, Radjesh J</creatorcontrib><creatorcontrib>Tanck, Michael W</creatorcontrib><creatorcontrib>Golledge, Jonathan</creatorcontrib><creatorcontrib>Broekhuizen, Lysette N</creatorcontrib><creatorcontrib>Legemate, Dink A</creatorcontrib><creatorcontrib>Stroes, Erik S.G</creatorcontrib><creatorcontrib>Norman, Paul E</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bisoendial, Radjesh J</au><au>Tanck, Michael W</au><au>Golledge, Jonathan</au><au>Broekhuizen, Lysette N</au><au>Legemate, Dink A</au><au>Stroes, Erik S.G</au><au>Norman, Paul E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>220</volume><issue>2</issue><spage>425</spage><epage>428</epage><pages>425-428</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Background Genetic variation in the gene ALOX5AP , encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA). Methods and results The association of the ALOX5AP haplotypes with AAA was assessed in a large population-based cohort of 613 men aged ≥65 years with screen-detected AAAs and 707 randomly selected age-matched controls without AAA. Taqman assays were used to assess seven previously described single nucleotide polymorphisms (SNPs) of ALOX5AP . Haplotypes A and B were defined by the four SNPs (SG13S25, SG13S114, SG13S89, SG13S32) and (SG13S377, SG13S114, SG13S41, SG13S35), respectively. After adjustment for cardiovascular risk factors, there were no significant differences in the distribution of ALOX5AP haplotypes between cases and controls. Conclusion A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>22129473</pmid><doi>10.1016/j.atherosclerosis.2011.10.040</doi><tpages>4</tpages></addata></record> |
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| subjects | 5-Lipoxygenase activating protein 5-Lipoxygenase-Activating Proteins - genetics Aged aneurysm Aneurysm formation Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - pathology arachidonic acid atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Case-Control Studies Chi-Square Distribution Diseases of the aorta gene expression regulation Gene Frequency genes Genetic Predisposition to Disease genetic variation Haplotypes Humans Inflammation Leukotrienes Male Medical sciences men myocardial infarction Netherlands Odds Ratio pathogenesis Phenotype Polymorphism, Single Nucleotide risk Risk Assessment Risk Factors single nucleotide polymorphism stroke |
| title | The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms |
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