Influence of matrix metalloproteinase-12 on fibrinogen level

Abstract In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction. In this study, we found that mean plasma fibrinogen level was approximately 10-fold higher in MMP12...

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Veröffentlicht in:	Atherosclerosis 2012-02, Vol.220 (2), p.351-354
Hauptverfasser:	Motterle, Anna, Xiao, Qingzhong, Kiechl, Stefan, Pender, Sylvia L.F, Morris, Gareth E, Willeit, Johann, Caulfield, Mark J, Ye, Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles Animals Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - enzymology Atherosclerosis - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Coronary heart disease England Fibrinogen Fibrinogen - metabolism Gene Frequency genetic polymorphism Genetic Predisposition to Disease Heart homozygosity Homozygote Humans in vitro studies Italy Linear Models Linkage Disequilibrium Logistic Models Matrix Metalloproteinase 12 - deficiency Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 12 - metabolism Matrix metalloproteinase-12 Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Myocardial infarction Myocardial Infarction - enzymology Myocardial Infarction - genetics Odds Ratio Phenotype Polymorphism, Single Nucleotide Proportional Hazards Models Prospective Studies risk Risk Assessment Risk Factors vascular tissues
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