The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis
► Studies on interaction of promastigotes and natural rubber with gold nanoparticles. ► Natural rubber membranes containing GNPs decreased the population growth rate. ► Future development of a flexible band-aid for skin lesions. ► Inhibiting the population growth of Leishmania brasiliensis parasites...
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| Veröffentlicht in: | Experimental parasitology 2012-02, Vol.130 (2), p.152-158 |
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| creator | Barboza-Filho, Carlos G. Cabrera, Flávio C. Dos Santos, Renivaldo J. De Saja Saez, Jose Antonio Job, Aldo E. |
| description | ► Studies on interaction of promastigotes and natural rubber with gold nanoparticles. ► Natural rubber membranes containing GNPs decreased the population growth rate. ► Future development of a flexible band-aid for skin lesions. ► Inhibiting the population growth of Leishmania brasiliensis parasites.
The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues. |
| doi_str_mv | 10.1016/j.exppara.2011.10.015 |
| format | Article |
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The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2011.10.015</identifier><identifier>PMID: 22101110</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>angiogenesis ; antibodies ; antigens ; Bandages, Hydrocolloid ; Culture Media ; disease diagnosis ; gold ; Gold - pharmacology ; Gold nanoparticles ; infectious diseases ; Leishmania ; Leishmania brasiliensis ; Leishmania braziliensis - drug effects ; Leishmania braziliensis - growth & development ; Leishmania braziliensis - physiology ; leishmaniasis ; Leishmaniasis, Cutaneous - parasitology ; Leishmaniasis, Cutaneous - therapy ; malaria ; Membranes, Artificial ; Metal Nanoparticles ; nanogold ; nanoparticles ; Natural rubber ; parasites ; parasitology ; pathogenicity ; population growth ; promastigotes ; Rubber ; skin lesions ; tissues</subject><ispartof>Experimental parasitology, 2012-02, Vol.130 (2), p.152-158</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-f639d8b52354d65f7aaf8565cd0e4892bd2e32ec44d2fa9ab062abca9e6eda1f3</citedby><cites>FETCH-LOGICAL-c388t-f639d8b52354d65f7aaf8565cd0e4892bd2e32ec44d2fa9ab062abca9e6eda1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exppara.2011.10.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22101110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barboza-Filho, Carlos G.</creatorcontrib><creatorcontrib>Cabrera, Flávio C.</creatorcontrib><creatorcontrib>Dos Santos, Renivaldo J.</creatorcontrib><creatorcontrib>De Saja Saez, Jose Antonio</creatorcontrib><creatorcontrib>Job, Aldo E.</creatorcontrib><title>The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>► Studies on interaction of promastigotes and natural rubber with gold nanoparticles. ► Natural rubber membranes containing GNPs decreased the population growth rate. ► Future development of a flexible band-aid for skin lesions. ► Inhibiting the population growth of Leishmania brasiliensis parasites.
The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues.</description><subject>angiogenesis</subject><subject>antibodies</subject><subject>antigens</subject><subject>Bandages, Hydrocolloid</subject><subject>Culture Media</subject><subject>disease diagnosis</subject><subject>gold</subject><subject>Gold - pharmacology</subject><subject>Gold nanoparticles</subject><subject>infectious diseases</subject><subject>Leishmania</subject><subject>Leishmania brasiliensis</subject><subject>Leishmania braziliensis - drug effects</subject><subject>Leishmania braziliensis - growth & development</subject><subject>Leishmania braziliensis - physiology</subject><subject>leishmaniasis</subject><subject>Leishmaniasis, Cutaneous - parasitology</subject><subject>Leishmaniasis, Cutaneous - therapy</subject><subject>malaria</subject><subject>Membranes, Artificial</subject><subject>Metal Nanoparticles</subject><subject>nanogold</subject><subject>nanoparticles</subject><subject>Natural rubber</subject><subject>parasites</subject><subject>parasitology</subject><subject>pathogenicity</subject><subject>population growth</subject><subject>promastigotes</subject><subject>Rubber</subject><subject>skin lesions</subject><subject>tissues</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu2zAQRYkiReO4_YS22mUlh6RIPVZBEKRNAQNZ1FkTI3IY05BEhZSK-u9DwU63XREYnDuPQ0K-MrphlJU3hw3-HUcIsOGUsVTbUCY_kBWjDc25EM0FWVHKRC7qRlySqxgPlNKacfGJXHKeejBGV8Tu9pi5wXYzDhozb7MBpjlAl4W5bTHc3M2pMvg0aXK6w6zHvg0wYMz8kE0pPO6P0fnOvxyX9BZd3PcwOMgSFl3ncIgufiYfLXQRv5zfNXn-8bC7f8y3Tz9_3d9tc13U9ZTbsmhM3UpeSGFKaSsAW8tSakMx3cFbw7HgqIUw3EIDLS05tBoaLNEAs8WaXJ_6jsG_zhgn1buosevSxn6OqmGVrGpWV4mUJ1IHH2NAq8bgeghHxahaDKuDOhtWi-GlnAyn3LfzhLnt0fxLvStNwPcTYMEreAkuquffqYNMv1EVshSJuD0RmEz8cRhU1G7Rb1xAPSnj3X-WeANlRJrx</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Barboza-Filho, Carlos G.</creator><creator>Cabrera, Flávio C.</creator><creator>Dos Santos, Renivaldo J.</creator><creator>De Saja Saez, Jose Antonio</creator><creator>Job, Aldo E.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis</title><author>Barboza-Filho, Carlos G. ; Cabrera, Flávio C. ; Dos Santos, Renivaldo J. ; De Saja Saez, Jose Antonio ; Job, Aldo E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-f639d8b52354d65f7aaf8565cd0e4892bd2e32ec44d2fa9ab062abca9e6eda1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>angiogenesis</topic><topic>antibodies</topic><topic>antigens</topic><topic>Bandages, Hydrocolloid</topic><topic>Culture Media</topic><topic>disease diagnosis</topic><topic>gold</topic><topic>Gold - pharmacology</topic><topic>Gold nanoparticles</topic><topic>infectious diseases</topic><topic>Leishmania</topic><topic>Leishmania brasiliensis</topic><topic>Leishmania braziliensis - drug effects</topic><topic>Leishmania braziliensis - growth & development</topic><topic>Leishmania braziliensis - physiology</topic><topic>leishmaniasis</topic><topic>Leishmaniasis, Cutaneous - parasitology</topic><topic>Leishmaniasis, Cutaneous - therapy</topic><topic>malaria</topic><topic>Membranes, Artificial</topic><topic>Metal Nanoparticles</topic><topic>nanogold</topic><topic>nanoparticles</topic><topic>Natural rubber</topic><topic>parasites</topic><topic>parasitology</topic><topic>pathogenicity</topic><topic>population growth</topic><topic>promastigotes</topic><topic>Rubber</topic><topic>skin lesions</topic><topic>tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barboza-Filho, Carlos G.</creatorcontrib><creatorcontrib>Cabrera, Flávio C.</creatorcontrib><creatorcontrib>Dos Santos, Renivaldo J.</creatorcontrib><creatorcontrib>De Saja Saez, Jose Antonio</creatorcontrib><creatorcontrib>Job, Aldo E.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barboza-Filho, Carlos G.</au><au>Cabrera, Flávio C.</au><au>Dos Santos, Renivaldo J.</au><au>De Saja Saez, Jose Antonio</au><au>Job, Aldo E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>130</volume><issue>2</issue><spage>152</spage><epage>158</epage><pages>152-158</pages><issn>0014-4894</issn><eissn>1090-2449</eissn><abstract>► Studies on interaction of promastigotes and natural rubber with gold nanoparticles. ► Natural rubber membranes containing GNPs decreased the population growth rate. ► Future development of a flexible band-aid for skin lesions. ► Inhibiting the population growth of Leishmania brasiliensis parasites.
The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22101110</pmid><doi>10.1016/j.exppara.2011.10.015</doi><tpages>7</tpages></addata></record> |
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| subjects | angiogenesis antibodies antigens Bandages, Hydrocolloid Culture Media disease diagnosis gold Gold - pharmacology Gold nanoparticles infectious diseases Leishmania Leishmania brasiliensis Leishmania braziliensis - drug effects Leishmania braziliensis - growth & development Leishmania braziliensis - physiology leishmaniasis Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - therapy malaria Membranes, Artificial Metal Nanoparticles nanogold nanoparticles Natural rubber parasites parasitology pathogenicity population growth promastigotes Rubber skin lesions tissues |
| title | The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis |
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