Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

ObjectiveTo investigate the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR).DesignOpen-label study.SettingOutpatients visiting the adult congenital heart disease department of our hospital.Pat...

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Veröffentlicht in:	Heart (British Cardiac Society) 2012-02, Vol.98 (4), p.325-329
Hauptverfasser:	Brili, S, Tousoulis, D, Antonopoulos, A S, Antoniades, C, Hatzis, G, Bakogiannis, C, Papageorgiou, N, Stefanadis, C
Format:	Artikel
Sprache:	eng
Schlagworte:	acute ischaemic syndromes Adult Aortic Coarctation - blood Aortic Coarctation - drug therapy Aortic Coarctation - physiopathology atherosclerosis Atorvastatin Calcium Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - drug effects Coarctation congenital heart disease coronary artery disease coronary physiology Cytokines - biosynthesis Cytokines - drug effects Disease Progression EBM endothelial function endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female Follow-Up Studies Heart attacks Heptanoic Acids - administration & dosage Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage inflammation interventional cardiology Male Medical sciences Nitric oxide oxidative stress pharmacology platelet activation Postoperative Period Prognosis Prospective Studies Pyrroles - administration & dosage renal disease stable angina Statins Studies Time Factors valvular disease valvuloplasty Vascular Surgical Procedures
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