Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts

The aim of the present study was to determine the expression and role of thrombospondin-2 (TSP-2) in systemic sclerosis (SSc). Both TSP-2 mRNA levels and protein synthesis in cell lysates were significantly lower in cultured SSc fibroblasts than in normal fibroblasts; however, the TSP-2 protein that...

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Veröffentlicht in:	The American journal of pathology 2012-02, Vol.180 (2), p.703-714
Hauptverfasser:	Kajihara, Ikko, Jinnin, Masatoshi, Yamane, Keitaro, Makino, Takamitsu, Honda, Noritoshi, Igata, Toshikatsu, Masuguchi, Shinichi, Fukushima, Satoshi, Okamoto, Yoshinobu, Hasegawa, Minoru, Fujimoto, Manabu, Ihn, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Biological and medical sciences Case-Control Studies Cells, Cultured Collagen Type I - metabolism Down-Regulation Extracellular Matrix - metabolism Female Fibroblasts - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Male Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 2 - metabolism Medical sciences Mice Mice, Inbred C57BL MicroRNAs - metabolism Middle Aged Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - metabolism Skin - metabolism Thrombospondins - biosynthesis Thrombospondins - metabolism Transforming Growth Factor beta - pharmacology Up-Regulation Young Adult
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