MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice
Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by microorganisms from the oral biofilm. Oral inoculation of mice with the periodontopathogen Aggregatibacter actinomycetemcomitans ( Aa) induces marked alveolar bone loss and local production of infla...
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| Veröffentlicht in: | Microbes and infection 2012-02, Vol.14 (2), p.198-206 |
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| creator | Madeira, Mila Fernandes Moreira Queiroz-Junior, Celso Martins Costa, Graciela Mitre Santos, Patrícia Campi Silveira, Elcia Maria Garlet, Gustavo Pompermaier Cisalpino, Patrícia Silva Teixeira, Mauro Martins Silva, Tarcília Aparecida Souza, Daniele da Glória |
| description | Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by microorganisms from the oral biofilm. Oral inoculation of mice with the periodontopathogen
Aggregatibacter actinomycetemcomitans (
Aa) induces marked alveolar bone loss and local production of inflammatory mediators, including Macrophage Migration Inhibitory Factor (MIF). The role of MIF for alveolar bone resorption during PD is not known. In the present study, experimental PD was induced in BALB/c wild-type mice (WT) and MIF knockout mice (MIF
−/−) through oral inoculation of
Aa. Despite enhanced number of bacteria, MIF
−/− mice had reduced infiltration of TRAP-positive cells and reduced alveolar bone loss. This was associated with decreased neutrophil accumulation and increased levels of IL-10 in periodontal tissues. TNF-α production was similar in both groups.
In vitro, LPS from
Aa enhanced osteoclastic activity in a MIF-dependent manner. In conclusion, MIF has role in controlling bacterial growth in the context of PD but contributes more significantly to the progression of bone loss during PD by directly affecting differentiation and activity of osteoclasts. |
| doi_str_mv | 10.1016/j.micinf.2011.09.005 |
| format | Article |
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Aggregatibacter actinomycetemcomitans (
Aa) induces marked alveolar bone loss and local production of inflammatory mediators, including Macrophage Migration Inhibitory Factor (MIF). The role of MIF for alveolar bone resorption during PD is not known. In the present study, experimental PD was induced in BALB/c wild-type mice (WT) and MIF knockout mice (MIF
−/−) through oral inoculation of
Aa. Despite enhanced number of bacteria, MIF
−/− mice had reduced infiltration of TRAP-positive cells and reduced alveolar bone loss. This was associated with decreased neutrophil accumulation and increased levels of IL-10 in periodontal tissues. TNF-α production was similar in both groups.
In vitro, LPS from
Aa enhanced osteoclastic activity in a MIF-dependent manner. In conclusion, MIF has role in controlling bacterial growth in the context of PD but contributes more significantly to the progression of bone loss during PD by directly affecting differentiation and activity of osteoclasts.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2011.09.005</identifier><identifier>PMID: 22016007</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Aggregatibacter actinomycetemcomitans ; Alveolar Bone Loss - microbiology ; Alveolar Bone Loss - pathology ; Animals ; Bacteriology ; Biological and medical sciences ; Bone loss ; Cell Differentiation ; Disease Models, Animal ; Disease Progression ; Fundamental and applied biological sciences. Psychology ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin-10 - metabolism ; Intramolecular Oxidoreductases - metabolism ; Macrophage Migration-Inhibitory Factors - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Microbiology ; MIF ; Miscellaneous ; Neutrophils - metabolism ; Osteoclasts - metabolism ; Osteoclasts - pathology ; Pasteurellaceae - growth & development ; Pasteurellaceae - physiology ; Pasteurellaceae Infections - microbiology ; Pasteurellaceae Infections - pathology ; Periodontal disease ; Periodontal Diseases - microbiology ; Periodontal Diseases - pathology ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Microbes and infection, 2012-02, Vol.14 (2), p.198-206</ispartof><rights>2011 Institut Pasteur</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-f9a6482d236cedb4dfd83927b359ca30383e8144953e6c99e613527771fb67e3</citedby><cites>FETCH-LOGICAL-c437t-f9a6482d236cedb4dfd83927b359ca30383e8144953e6c99e613527771fb67e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micinf.2011.09.005$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25466658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22016007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madeira, Mila Fernandes Moreira</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso Martins</creatorcontrib><creatorcontrib>Costa, Graciela Mitre</creatorcontrib><creatorcontrib>Santos, Patrícia Campi</creatorcontrib><creatorcontrib>Silveira, Elcia Maria</creatorcontrib><creatorcontrib>Garlet, Gustavo Pompermaier</creatorcontrib><creatorcontrib>Cisalpino, Patrícia Silva</creatorcontrib><creatorcontrib>Teixeira, Mauro Martins</creatorcontrib><creatorcontrib>Silva, Tarcília Aparecida</creatorcontrib><creatorcontrib>Souza, Daniele da Glória</creatorcontrib><title>MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by microorganisms from the oral biofilm. Oral inoculation of mice with the periodontopathogen
Aggregatibacter actinomycetemcomitans (
Aa) induces marked alveolar bone loss and local production of inflammatory mediators, including Macrophage Migration Inhibitory Factor (MIF). The role of MIF for alveolar bone resorption during PD is not known. In the present study, experimental PD was induced in BALB/c wild-type mice (WT) and MIF knockout mice (MIF
−/−) through oral inoculation of
Aa. Despite enhanced number of bacteria, MIF
−/− mice had reduced infiltration of TRAP-positive cells and reduced alveolar bone loss. This was associated with decreased neutrophil accumulation and increased levels of IL-10 in periodontal tissues. TNF-α production was similar in both groups.
In vitro, LPS from
Aa enhanced osteoclastic activity in a MIF-dependent manner. In conclusion, MIF has role in controlling bacterial growth in the context of PD but contributes more significantly to the progression of bone loss during PD by directly affecting differentiation and activity of osteoclasts.</description><subject>Aggregatibacter actinomycetemcomitans</subject><subject>Alveolar Bone Loss - microbiology</subject><subject>Alveolar Bone Loss - pathology</subject><subject>Animals</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Bone loss</subject><subject>Cell Differentiation</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-10 - metabolism</subject><subject>Intramolecular Oxidoreductases - metabolism</subject><subject>Macrophage Migration-Inhibitory Factors - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>Microbiology</subject><subject>MIF</subject><subject>Miscellaneous</subject><subject>Neutrophils - metabolism</subject><subject>Osteoclasts - metabolism</subject><subject>Osteoclasts - pathology</subject><subject>Pasteurellaceae - growth & development</subject><subject>Pasteurellaceae - physiology</subject><subject>Pasteurellaceae Infections - microbiology</subject><subject>Pasteurellaceae Infections - pathology</subject><subject>Periodontal disease</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Diseases - pathology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFDEUhYMozo--gUhtxFWVSeWvshFkcHRgxM0s3IVUciNpqittbkrw7SdNt7qbVQL5zs25HyFvGB0YZerDbtgnn9Y4jJSxgZqBUvmMXDKtTK-Z-PG83cdJ9UJqc0GuEHeUMqmVeEkuxpZRlOpLEr7d3XZpDZsH7DJWyH5xWLuQYoQCa02uprx2bg2dz2stad5qQ2vuDiX_LIB4fM6xO0BJOTTELS2N4BDa4K6VhFfkRXQLwuvzeU0ebj8_3Hzt779_ubv5dN97wXXto3FKTGMYufIQZhFimLgZ9cyl8Y5TPnGYmBBGclDeGFCMy1FrzeKsNPBr8v40tjX7tQFWu0_oYVncCnlDa5iWWkvJGilOpC8ZsUC0h5L2rvyxjNqjXbuzJ7v2aNdSY5vdFnt7_mCb9xD-hf7qbMC7M-DQuyUWt_qE_zkplFJyatzHEwfNxu8ExaJPsLatUwFfbcjp6SaPu4ObGw</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Madeira, Mila Fernandes Moreira</creator><creator>Queiroz-Junior, Celso Martins</creator><creator>Costa, Graciela Mitre</creator><creator>Santos, Patrícia Campi</creator><creator>Silveira, Elcia Maria</creator><creator>Garlet, Gustavo Pompermaier</creator><creator>Cisalpino, Patrícia Silva</creator><creator>Teixeira, Mauro Martins</creator><creator>Silva, Tarcília Aparecida</creator><creator>Souza, Daniele da Glória</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice</title><author>Madeira, Mila Fernandes Moreira ; Queiroz-Junior, Celso Martins ; Costa, Graciela Mitre ; Santos, Patrícia Campi ; Silveira, Elcia Maria ; Garlet, Gustavo Pompermaier ; Cisalpino, Patrícia Silva ; Teixeira, Mauro Martins ; Silva, Tarcília Aparecida ; Souza, Daniele da Glória</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-f9a6482d236cedb4dfd83927b359ca30383e8144953e6c99e613527771fb67e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aggregatibacter actinomycetemcomitans</topic><topic>Alveolar Bone Loss - microbiology</topic><topic>Alveolar Bone Loss - pathology</topic><topic>Animals</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Bone loss</topic><topic>Cell Differentiation</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin-10 - metabolism</topic><topic>Intramolecular Oxidoreductases - metabolism</topic><topic>Macrophage Migration-Inhibitory Factors - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Knockout</topic><topic>Microbiology</topic><topic>MIF</topic><topic>Miscellaneous</topic><topic>Neutrophils - metabolism</topic><topic>Osteoclasts - metabolism</topic><topic>Osteoclasts - pathology</topic><topic>Pasteurellaceae - growth & development</topic><topic>Pasteurellaceae - physiology</topic><topic>Pasteurellaceae Infections - microbiology</topic><topic>Pasteurellaceae Infections - pathology</topic><topic>Periodontal disease</topic><topic>Periodontal Diseases - microbiology</topic><topic>Periodontal Diseases - pathology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madeira, Mila Fernandes Moreira</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso Martins</creatorcontrib><creatorcontrib>Costa, Graciela Mitre</creatorcontrib><creatorcontrib>Santos, Patrícia Campi</creatorcontrib><creatorcontrib>Silveira, Elcia Maria</creatorcontrib><creatorcontrib>Garlet, Gustavo Pompermaier</creatorcontrib><creatorcontrib>Cisalpino, Patrícia Silva</creatorcontrib><creatorcontrib>Teixeira, Mauro Martins</creatorcontrib><creatorcontrib>Silva, Tarcília Aparecida</creatorcontrib><creatorcontrib>Souza, Daniele da Glória</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madeira, Mila Fernandes Moreira</au><au>Queiroz-Junior, Celso Martins</au><au>Costa, Graciela Mitre</au><au>Santos, Patrícia Campi</au><au>Silveira, Elcia Maria</au><au>Garlet, Gustavo Pompermaier</au><au>Cisalpino, Patrícia Silva</au><au>Teixeira, Mauro Martins</au><au>Silva, Tarcília Aparecida</au><au>Souza, Daniele da Glória</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>14</volume><issue>2</issue><spage>198</spage><epage>206</epage><pages>198-206</pages><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by microorganisms from the oral biofilm. Oral inoculation of mice with the periodontopathogen
Aggregatibacter actinomycetemcomitans (
Aa) induces marked alveolar bone loss and local production of inflammatory mediators, including Macrophage Migration Inhibitory Factor (MIF). The role of MIF for alveolar bone resorption during PD is not known. In the present study, experimental PD was induced in BALB/c wild-type mice (WT) and MIF knockout mice (MIF
−/−) through oral inoculation of
Aa. Despite enhanced number of bacteria, MIF
−/− mice had reduced infiltration of TRAP-positive cells and reduced alveolar bone loss. This was associated with decreased neutrophil accumulation and increased levels of IL-10 in periodontal tissues. TNF-α production was similar in both groups.
In vitro, LPS from
Aa enhanced osteoclastic activity in a MIF-dependent manner. In conclusion, MIF has role in controlling bacterial growth in the context of PD but contributes more significantly to the progression of bone loss during PD by directly affecting differentiation and activity of osteoclasts.</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>22016007</pmid><doi>10.1016/j.micinf.2011.09.005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aggregatibacter actinomycetemcomitans Alveolar Bone Loss - microbiology Alveolar Bone Loss - pathology Animals Bacteriology Biological and medical sciences Bone loss Cell Differentiation Disease Models, Animal Disease Progression Fundamental and applied biological sciences. Psychology Inflammation Inflammation Mediators - metabolism Interleukin-10 - metabolism Intramolecular Oxidoreductases - metabolism Macrophage Migration-Inhibitory Factors - metabolism Mice Mice, Inbred BALB C Mice, Knockout Microbiology MIF Miscellaneous Neutrophils - metabolism Osteoclasts - metabolism Osteoclasts - pathology Pasteurellaceae - growth & development Pasteurellaceae - physiology Pasteurellaceae Infections - microbiology Pasteurellaceae Infections - pathology Periodontal disease Periodontal Diseases - microbiology Periodontal Diseases - pathology Tumor Necrosis Factor-alpha - metabolism |
| title | MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice |
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