Local delivery of IL-2 reduces atherosclerosis via expansion of regulatory T cells

Abstract Objective Recent studies indicate that regulatory T cells (Tregs) attenuate murine atherosclerosis. Since interleukin (IL)-2 induces Tregs proliferation, we tested the impact of L19-IL2, a fusion antibody specific to extra-domain B of fibronectin (ED-B) containing an active human IL-2 molec...

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Veröffentlicht in:	Atherosclerosis 2012-02, Vol.220 (2), p.329-336
Hauptverfasser:	Dietrich, Thore, Hucko, Thomas, Schneemann, Christiane, Neumann, Marleen, Menrad, Andreas, Willuda, Joerg, Atrott, Kirstin, Stibenz, Dietger, Fleck, Eckart, Graf, Kristof, Menssen, Hans D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - immunology Aorta - metabolism Aorta - pathology Aortic Diseases - genetics Aortic Diseases - immunology Aortic Diseases - metabolism Aortic Diseases - pathology Aortic Diseases - prevention & control apoE −/− mice Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiovascular Cardiovascular Agents - administration & dosage Cell Proliferation - drug effects Diet, High-Fat Disease Models, Animal Extracellular matrix Extradomain B fibronectin Fundamental and applied biological sciences. Psychology Humans Injections, Intravenous L19-IL2 Lipids - blood Macrophages - drug effects Macrophages - immunology Magnetic Resonance Imaging Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Recombinant Fusion Proteins - administration & dosage T-lymphocytes T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Time Factors Vertebrates: cardiovascular system
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