Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4

An efficient and green synthesis of functionalized cyano pyridines has been achieved via montmorillonite K-10 mediated multi-component reaction in a chemo- and regioselective manner. The four-component reaction of β-keto ester, arylaldehyde, malononitrile and an alcohol provided a variety of pyridin...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-02, Vol.48, p.265-274
Hauptverfasser:	Ram Reddy, T., Rajeshwar Reddy, G., Srinivasula Reddy, L., Jammula, Subbarao, Lingappa, Y., Kapavarapu, Ravikumar, Meda, Chandana Lakshmi T., Parsa, Kishore V.L., Pal, Manojit
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Bentonite - chemistry Biological and medical sciences Catalysis Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Green Chemistry Technology - methods Magnetic Resonance Spectroscopy Malononitrile Mass Spectrometry Medical sciences Models, Molecular Molecular Dynamics Simulation Montmorillonite K-10 PDE4 Pharmacology. Drug treatments Phosphodiesterase 4 Inhibitors - chemical synthesis Phosphodiesterase 4 Inhibitors - chemistry Phosphodiesterase 4 Inhibitors - pharmacology Pyridine Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Respiratory system Spectroscopy, Fourier Transform Infrared β-keto ester
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