Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression of interleukin-1β phenocopies human pathology with evolution of esophagitis, Barrett-like metaplasia and...

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Veröffentlicht in:	Cancer cell 2012-01, Vol.21 (1), p.36-51
Hauptverfasser:	Quante, Michael, Bhagat, Govind, Abrams, Julian A., Marache, Frederic, Good, Pamela, Lee, Michele D., Lee, Yoomi, Friedman, Richard, Asfaha, Samuel, Dubeykovskaya, Zinaida, Mahmood, Umar, Figueiredo, Jose-Luiz, Kitajewski, Jan, Shawber, Carrie, Lightdale, Charles J., Rustgi, Anil K., Wang, Timothy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Animals Barrett Esophagus - etiology Barrett Esophagus - pathology Bile Acids and Salts - pharmacology Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Cardia - pathology CDX2 Transcription Factor Esophageal Neoplasms - pathology Esophagitis - pathology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Metaplasia - pathology Mice Mice, Transgenic Mucins - genetics Mucins - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Peptides - genetics Peptides - metabolism Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Stem Cells - pathology Transcription Factors - genetics Transcription Factors - metabolism Trefoil Factor-2 Up-Regulation
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