Dynein Dysfunction Disrupts Intracellular Vesicle Trafficking Bidirectionally and Perturbs Synaptic Vesicle Docking via Endocytic Disturbances: A Potential Mechanism Underlying Age-Dependent Impairment of Cognitive Function

Although genetic studies have demonstrated that β-amyloid protein (Aβ) plays a pivotal role in Alzheimer's disease (AD) pathogenesis, how aging contributes to AD onset remains unclear. Moreover, growing evidence suggests that Aβ-independent mechanisms, such as altered intracellular signaling ca...

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Veröffentlicht in:	The American journal of pathology 2012-02, Vol.180 (2), p.550-561
Hauptverfasser:	KIMURA, Nobuyuki, OKABAYASHI, Sachi, ONO, Fumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Age Factors Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Animals Biological and medical sciences Biological Transport Brain Chemistry - physiology Cerebral Cortex - metabolism Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - physiopathology Dynactin Complex Dyneins - physiology Endocytosis - physiology Enzyme Inhibitors - pharmacology Investigative techniques, diagnostic techniques (general aspects) Macaca fascicularis Medical sciences Microtubule-Associated Proteins - metabolism Microtubules - metabolism Neurofilament Proteins - metabolism Neurons - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques rab GTP-Binding Proteins - metabolism Receptor, trkB - metabolism Synaptic Vesicles - metabolism
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