Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice
The present study was designed to investigate the hypoglycemic and hypolipidemic properties of Passiflora incarnata Linn. leaves which are widely used as traditional treatment for diabetes mellitus. The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg,...
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| Veröffentlicht in: | Journal of ethnopharmacology 2012-02, Vol.139 (3), p.801-806 |
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| creator | Gupta, Rakesh Kumar Kumar, Dharmendra Chaudhary, Amrendra Kumar Maithani, Mukesh Singh, Ranjit |
| description | The present study was designed to investigate the hypoglycemic and hypolipidemic properties of Passiflora incarnata Linn. leaves which are widely used as traditional treatment for diabetes mellitus.
The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg, for 15 days) to streptozotocin-induced diabetic mice. Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic mice treated with methanolic extracts were assessed and compared with normal, diabetic control and standard drug treated mice. Histological examination during 15 days of treatment was also carried out.
Methanolic extract (200mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic mice. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic mice, when compared with diabetic, normal and standard drug treated mice. Histopathological studies of the pancreas showed comparable regeneration of the cells by extract which were earlier necrosed by streptozotocin.
Methanolic extract of Passiflora incarnata exhibit significant anti-hyperglycemic and hypolipidemic activities in streptozotocin-induced diabetes in mice. |
| doi_str_mv | 10.1016/j.jep.2011.12.021 |
| format | Article |
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The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg, for 15 days) to streptozotocin-induced diabetic mice. Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic mice treated with methanolic extracts were assessed and compared with normal, diabetic control and standard drug treated mice. Histological examination during 15 days of treatment was also carried out.
Methanolic extract (200mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic mice. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic mice, when compared with diabetic, normal and standard drug treated mice. Histopathological studies of the pancreas showed comparable regeneration of the cells by extract which were earlier necrosed by streptozotocin.
Methanolic extract of Passiflora incarnata exhibit significant anti-hyperglycemic and hypolipidemic activities in streptozotocin-induced diabetes in mice.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2011.12.021</identifier><identifier>PMID: 22212504</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Antidiabetes ; blood glucose ; Blood Glucose - metabolism ; blood lipids ; body weight ; Body Weight - drug effects ; diabetes mellitus ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; drugs ; fasting ; Female ; Glibenclamide ; glucose ; glucose tolerance ; Glucose Tolerance Test ; Glycosuria - drug therapy ; histopathology ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; leaves ; Lipid profile ; Lipids - blood ; Male ; Mice ; Mice, Inbred Strains ; Necrosis ; oral administration ; pancreas ; Pancreas - drug effects ; Pancreas - pathology ; Passiflora ; Passiflora incarnata ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Regeneration - drug effects ; Streptozotocin ; urine</subject><ispartof>Journal of ethnopharmacology, 2012-02, Vol.139 (3), p.801-806</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-96d4a13d798091af77881a492cac3c7f79eba662593bd9f72a425f070bc1850c3</citedby><cites>FETCH-LOGICAL-c376t-96d4a13d798091af77881a492cac3c7f79eba662593bd9f72a425f070bc1850c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874111008993$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22212504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Rakesh Kumar</creatorcontrib><creatorcontrib>Kumar, Dharmendra</creatorcontrib><creatorcontrib>Chaudhary, Amrendra Kumar</creatorcontrib><creatorcontrib>Maithani, Mukesh</creatorcontrib><creatorcontrib>Singh, Ranjit</creatorcontrib><title>Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The present study was designed to investigate the hypoglycemic and hypolipidemic properties of Passiflora incarnata Linn. leaves which are widely used as traditional treatment for diabetes mellitus.
The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg, for 15 days) to streptozotocin-induced diabetic mice. Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic mice treated with methanolic extracts were assessed and compared with normal, diabetic control and standard drug treated mice. Histological examination during 15 days of treatment was also carried out.
Methanolic extract (200mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic mice. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic mice, when compared with diabetic, normal and standard drug treated mice. Histopathological studies of the pancreas showed comparable regeneration of the cells by extract which were earlier necrosed by streptozotocin.
Methanolic extract of Passiflora incarnata exhibit significant anti-hyperglycemic and hypolipidemic activities in streptozotocin-induced diabetes in mice.</description><subject>Animals</subject><subject>Antidiabetes</subject><subject>blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>blood lipids</subject><subject>body weight</subject><subject>Body Weight - drug effects</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>drugs</subject><subject>fasting</subject><subject>Female</subject><subject>Glibenclamide</subject><subject>glucose</subject><subject>glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Glycosuria - drug therapy</subject><subject>histopathology</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>leaves</subject><subject>Lipid profile</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Necrosis</subject><subject>oral administration</subject><subject>pancreas</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Passiflora</subject><subject>Passiflora incarnata</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Regeneration - drug effects</subject><subject>Streptozotocin</subject><subject>urine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQQIMo7uzqB3jRvnnqNpVOdzp4WhZ1hQEF3auhOp1IDTPJmGQW1q83Q68ePRUFrx7FY-wV8A44jO923c4dO8EBOhAdF_CEbWBSolWD6p-yDe_V1E5KwgW7zHnHOVcg-XN2IYQAMXC5YT-uQ6GFcHaFbIO20D2Vhyb65ivmTH4fEzYULKaABZsthdDVvckluWOJv2OJlkJLYTlZtzSryeUzciDrXrBnHvfZvXycV-zu44fvN7ft9sunzzfX29b2aiytHheJ0C9KT1wDeqWmCVBqYdH2Vnml3YzjKAbdz4v2SqAUg-eKzxamgdv-ir1dvccUf51cLuZA2br9HoOLp2w01CRS9KqSsJI2xZyT8-aY6IDpwQA356pmZ2pVc65qQJhatd68frSf5oNb_l38zViBNyvgMRr8mSibu2_VIGtyqTQfK_F-JVytcE8umWzJhdqMkrPFLJH-88AfIfuRSw</recordid><startdate>20120215</startdate><enddate>20120215</enddate><creator>Gupta, Rakesh Kumar</creator><creator>Kumar, Dharmendra</creator><creator>Chaudhary, Amrendra Kumar</creator><creator>Maithani, Mukesh</creator><creator>Singh, Ranjit</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120215</creationdate><title>Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice</title><author>Gupta, Rakesh Kumar ; Kumar, Dharmendra ; Chaudhary, Amrendra Kumar ; Maithani, Mukesh ; Singh, Ranjit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-96d4a13d798091af77881a492cac3c7f79eba662593bd9f72a425f070bc1850c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antidiabetes</topic><topic>blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>blood lipids</topic><topic>body weight</topic><topic>Body Weight - drug effects</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>drugs</topic><topic>fasting</topic><topic>Female</topic><topic>Glibenclamide</topic><topic>glucose</topic><topic>glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Glycosuria - drug therapy</topic><topic>histopathology</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>leaves</topic><topic>Lipid profile</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Necrosis</topic><topic>oral administration</topic><topic>pancreas</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Passiflora</topic><topic>Passiflora incarnata</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Regeneration - drug effects</topic><topic>Streptozotocin</topic><topic>urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Rakesh Kumar</creatorcontrib><creatorcontrib>Kumar, Dharmendra</creatorcontrib><creatorcontrib>Chaudhary, Amrendra Kumar</creatorcontrib><creatorcontrib>Maithani, Mukesh</creatorcontrib><creatorcontrib>Singh, Ranjit</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Rakesh Kumar</au><au>Kumar, Dharmendra</au><au>Chaudhary, Amrendra Kumar</au><au>Maithani, Mukesh</au><au>Singh, Ranjit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2012-02-15</date><risdate>2012</risdate><volume>139</volume><issue>3</issue><spage>801</spage><epage>806</epage><pages>801-806</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>The present study was designed to investigate the hypoglycemic and hypolipidemic properties of Passiflora incarnata Linn. leaves which are widely used as traditional treatment for diabetes mellitus.
The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg, for 15 days) to streptozotocin-induced diabetic mice. Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic mice treated with methanolic extracts were assessed and compared with normal, diabetic control and standard drug treated mice. Histological examination during 15 days of treatment was also carried out.
Methanolic extract (200mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic mice. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic mice, when compared with diabetic, normal and standard drug treated mice. Histopathological studies of the pancreas showed comparable regeneration of the cells by extract which were earlier necrosed by streptozotocin.
Methanolic extract of Passiflora incarnata exhibit significant anti-hyperglycemic and hypolipidemic activities in streptozotocin-induced diabetes in mice.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22212504</pmid><doi>10.1016/j.jep.2011.12.021</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antidiabetes blood glucose Blood Glucose - metabolism blood lipids body weight Body Weight - drug effects diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology drugs fasting Female Glibenclamide glucose glucose tolerance Glucose Tolerance Test Glycosuria - drug therapy histopathology Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use leaves Lipid profile Lipids - blood Male Mice Mice, Inbred Strains Necrosis oral administration pancreas Pancreas - drug effects Pancreas - pathology Passiflora Passiflora incarnata Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Regeneration - drug effects Streptozotocin urine |
| title | Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice |
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