A seminal monograph: Mackay and Burnet's Autoimmune diseases
Mackay and Burnet's Autoimmune diseases, published in 1962, marked the beginning of autoimmunity as a clinical science and led to the future acceptance of the existence of autoimmunity. While there is still controversy regarding the mechanisms of autoimmunity, the authors' insightful hypot...
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| Veröffentlicht in: | Medical journal of Australia 2012-01, Vol.196 (1), p.74-76 |
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| container_end_page | 76 |
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| container_title | Medical journal of Australia |
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| creator | Roberts-Thomson, Peter J Jackson, Michael W Gordon, Thomas P |
| description | Mackay and Burnet's Autoimmune diseases, published in 1962, marked the beginning of autoimmunity as a clinical science and led to the future acceptance of the existence of autoimmunity. While there is still controversy regarding the mechanisms of autoimmunity, the authors' insightful hypothesis based on clonal selection theory and the emergence of "forbidden clones", due to somatic mutations, is still current, with recent evidence giving further credence to this hypothesis. We salute Mackay and Burnet on the 50th anniversary of this seminal publication. It is particularly pleasing that it has an iconic Australian origin. |
| doi_str_mv | 10.5694/mja11.10821 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0025-729X |
| ispartof | Medical journal of Australia, 2012-01, Vol.196 (1), p.74-76 |
| issn | 0025-729X 1326-5377 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_917163461 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Australia Autoimmune Diseases - history Burnet History, 20th Century Humans Mackay Periodicals as Topic - history |
| title | A seminal monograph: Mackay and Burnet's Autoimmune diseases |
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