Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey
Environmental factors may play an important role in the pathogenesis of IBD. The history of patients of the German IBD twin study was analyzed by questionnaires and interviews. Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) wer...
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| Veröffentlicht in: | Journal of Crohn's and colitis 2012-02, Vol.6 (1), p.29-42 |
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| creator | Spehlmann, Martina E Begun, Alexander Z Saroglou, Ekaterini Hinrichs, Frank Tiemann, Ute Raedler, Andreas Schreiber, Stefan |
| description | Environmental factors may play an important role in the pathogenesis of IBD. The history of patients of the German IBD twin study was analyzed by questionnaires and interviews.
Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) were characterized in detail including demography, medical history and concomitant medications. Controls comprised of non-twin IBD patients (n=392) and healthy subjects (n=207).
The most significant variables that were associated with Crohn's disease (CD) or ulcerative colitis (UC) included living abroad before time of diagnosis (OR, 4.32; 95% CI, 1.57-13.69), high frequency of antibiotic use (MZ CD OR, 5.03; 95% CI 1.61-17.74, DZ CD OR, 7.66; 95% CI, 3.63-16.82, MZ UC OR, 3.82; 95% CI, 1.45-10.56, DZ UC OR, 3.08; CI, 1.63-5.92), high consumption of processed meat including sausage (MZ CD OR, 7.9; 95% CI, 2.15-38.12, DZ CD OR, 10.75; 95% CI, 4.82-25.55, MZ UC OR, 5.69; 95% CI, 1.89-19.48, DZ UC OR, 18.11; 95% CI, 7.34-50.85), and recall of bacterial gastrointestinal infections (MZ CD OR, 15.9; 95% CI, 4.33-77.14, DZ CD OR, 17.21; 95% CI, 4.47-112.5, MZ UC OR, 5.87; 95% CI, 1.61-28.0, DZ UC OR, 11.34; 95% CI, 4.81-29.67).
This study reinforced the association of life style events, in particular a specific dietary and infections history, with IBD. Alteration of gut flora or alterations of the mucosal immune system in reactivity to the flora could be an important factor to explain the relationship between life-style and disease. |
| doi_str_mv | 10.1016/j.crohns.2011.06.007 |
| format | Article |
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Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) were characterized in detail including demography, medical history and concomitant medications. Controls comprised of non-twin IBD patients (n=392) and healthy subjects (n=207).
The most significant variables that were associated with Crohn's disease (CD) or ulcerative colitis (UC) included living abroad before time of diagnosis (OR, 4.32; 95% CI, 1.57-13.69), high frequency of antibiotic use (MZ CD OR, 5.03; 95% CI 1.61-17.74, DZ CD OR, 7.66; 95% CI, 3.63-16.82, MZ UC OR, 3.82; 95% CI, 1.45-10.56, DZ UC OR, 3.08; CI, 1.63-5.92), high consumption of processed meat including sausage (MZ CD OR, 7.9; 95% CI, 2.15-38.12, DZ CD OR, 10.75; 95% CI, 4.82-25.55, MZ UC OR, 5.69; 95% CI, 1.89-19.48, DZ UC OR, 18.11; 95% CI, 7.34-50.85), and recall of bacterial gastrointestinal infections (MZ CD OR, 15.9; 95% CI, 4.33-77.14, DZ CD OR, 17.21; 95% CI, 4.47-112.5, MZ UC OR, 5.87; 95% CI, 1.61-28.0, DZ UC OR, 11.34; 95% CI, 4.81-29.67).
This study reinforced the association of life style events, in particular a specific dietary and infections history, with IBD. Alteration of gut flora or alterations of the mucosal immune system in reactivity to the flora could be an important factor to explain the relationship between life-style and disease.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1016/j.crohns.2011.06.007</identifier><identifier>PMID: 22261525</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Child ; Colitis, Ulcerative - etiology ; Communicable Diseases - complications ; Comorbidity ; Crohn Disease - etiology ; Diet ; Diseases in Twins - etiology ; Female ; Germany ; Humans ; Life Style ; Male ; Middle Aged ; Risk Factors ; Surveys and Questionnaires ; Twins, Dizygotic ; Twins, Monozygotic ; Young Adult</subject><ispartof>Journal of Crohn's and colitis, 2012-02, Vol.6 (1), p.29-42</ispartof><rights>Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-8bf6052958642ede39e69f0cd548a8ed9a98dac1642d46713ae04b4c5467b8183</citedby><cites>FETCH-LOGICAL-c352t-8bf6052958642ede39e69f0cd548a8ed9a98dac1642d46713ae04b4c5467b8183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22261525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spehlmann, Martina E</creatorcontrib><creatorcontrib>Begun, Alexander Z</creatorcontrib><creatorcontrib>Saroglou, Ekaterini</creatorcontrib><creatorcontrib>Hinrichs, Frank</creatorcontrib><creatorcontrib>Tiemann, Ute</creatorcontrib><creatorcontrib>Raedler, Andreas</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><title>Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>Environmental factors may play an important role in the pathogenesis of IBD. The history of patients of the German IBD twin study was analyzed by questionnaires and interviews.
Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) were characterized in detail including demography, medical history and concomitant medications. Controls comprised of non-twin IBD patients (n=392) and healthy subjects (n=207).
The most significant variables that were associated with Crohn's disease (CD) or ulcerative colitis (UC) included living abroad before time of diagnosis (OR, 4.32; 95% CI, 1.57-13.69), high frequency of antibiotic use (MZ CD OR, 5.03; 95% CI 1.61-17.74, DZ CD OR, 7.66; 95% CI, 3.63-16.82, MZ UC OR, 3.82; 95% CI, 1.45-10.56, DZ UC OR, 3.08; CI, 1.63-5.92), high consumption of processed meat including sausage (MZ CD OR, 7.9; 95% CI, 2.15-38.12, DZ CD OR, 10.75; 95% CI, 4.82-25.55, MZ UC OR, 5.69; 95% CI, 1.89-19.48, DZ UC OR, 18.11; 95% CI, 7.34-50.85), and recall of bacterial gastrointestinal infections (MZ CD OR, 15.9; 95% CI, 4.33-77.14, DZ CD OR, 17.21; 95% CI, 4.47-112.5, MZ UC OR, 5.87; 95% CI, 1.61-28.0, DZ UC OR, 11.34; 95% CI, 4.81-29.67).
This study reinforced the association of life style events, in particular a specific dietary and infections history, with IBD. Alteration of gut flora or alterations of the mucosal immune system in reactivity to the flora could be an important factor to explain the relationship between life-style and disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Colitis, Ulcerative - etiology</subject><subject>Communicable Diseases - complications</subject><subject>Comorbidity</subject><subject>Crohn Disease - etiology</subject><subject>Diet</subject><subject>Diseases in Twins - etiology</subject><subject>Female</subject><subject>Germany</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><subject>Young Adult</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKxDAQhoMont9AJHdetSZpkibeiXgCQRC9Dmk7ZbP2oJnWZd_erKtezen_Z4aPkDPOcs64vlzmdRwXA-aCcZ4znTNW7pBDbkqdSVna3Z-8yKyV-oAcIS4ZU1aVZp8cCCE0V0IdEngJ-E5bX09jRBoGeg-x9wOdVmFAugrTIjXbzve9T4o1rcYVdLQJCB7hikbAuZuQji319HMGnMI4DD5EyKokaCjO8QvWJ2Sv9R3C6W88Jm93t683D9nT8_3jzfVTVhdKTJmpWs2UsMpoKaCBwoK2LasbJY030FhvTeNrnqaN1CUvPDBZyVqlojLcFMfkYrv3I44_37g-YA1d5wcYZ3SWl1wLo2xSyq0yQUSM0LqPGHof144zt-Hrlm7L1234OqZd4pts578H5qqH5t_0B7T4BuxXeho</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Spehlmann, Martina E</creator><creator>Begun, Alexander Z</creator><creator>Saroglou, Ekaterini</creator><creator>Hinrichs, Frank</creator><creator>Tiemann, Ute</creator><creator>Raedler, Andreas</creator><creator>Schreiber, Stefan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey</title><author>Spehlmann, Martina E ; Begun, Alexander Z ; Saroglou, Ekaterini ; Hinrichs, Frank ; Tiemann, Ute ; Raedler, Andreas ; Schreiber, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-8bf6052958642ede39e69f0cd548a8ed9a98dac1642d46713ae04b4c5467b8183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Child</topic><topic>Colitis, Ulcerative - etiology</topic><topic>Communicable Diseases - complications</topic><topic>Comorbidity</topic><topic>Crohn Disease - etiology</topic><topic>Diet</topic><topic>Diseases in Twins - etiology</topic><topic>Female</topic><topic>Germany</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spehlmann, Martina E</creatorcontrib><creatorcontrib>Begun, Alexander Z</creatorcontrib><creatorcontrib>Saroglou, Ekaterini</creatorcontrib><creatorcontrib>Hinrichs, Frank</creatorcontrib><creatorcontrib>Tiemann, Ute</creatorcontrib><creatorcontrib>Raedler, Andreas</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spehlmann, Martina E</au><au>Begun, Alexander Z</au><au>Saroglou, Ekaterini</au><au>Hinrichs, Frank</au><au>Tiemann, Ute</au><au>Raedler, Andreas</au><au>Schreiber, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2012-02</date><risdate>2012</risdate><volume>6</volume><issue>1</issue><spage>29</spage><epage>42</epage><pages>29-42</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>Environmental factors may play an important role in the pathogenesis of IBD. The history of patients of the German IBD twin study was analyzed by questionnaires and interviews.
Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) were characterized in detail including demography, medical history and concomitant medications. Controls comprised of non-twin IBD patients (n=392) and healthy subjects (n=207).
The most significant variables that were associated with Crohn's disease (CD) or ulcerative colitis (UC) included living abroad before time of diagnosis (OR, 4.32; 95% CI, 1.57-13.69), high frequency of antibiotic use (MZ CD OR, 5.03; 95% CI 1.61-17.74, DZ CD OR, 7.66; 95% CI, 3.63-16.82, MZ UC OR, 3.82; 95% CI, 1.45-10.56, DZ UC OR, 3.08; CI, 1.63-5.92), high consumption of processed meat including sausage (MZ CD OR, 7.9; 95% CI, 2.15-38.12, DZ CD OR, 10.75; 95% CI, 4.82-25.55, MZ UC OR, 5.69; 95% CI, 1.89-19.48, DZ UC OR, 18.11; 95% CI, 7.34-50.85), and recall of bacterial gastrointestinal infections (MZ CD OR, 15.9; 95% CI, 4.33-77.14, DZ CD OR, 17.21; 95% CI, 4.47-112.5, MZ UC OR, 5.87; 95% CI, 1.61-28.0, DZ UC OR, 11.34; 95% CI, 4.81-29.67).
This study reinforced the association of life style events, in particular a specific dietary and infections history, with IBD. Alteration of gut flora or alterations of the mucosal immune system in reactivity to the flora could be an important factor to explain the relationship between life-style and disease.</abstract><cop>England</cop><pmid>22261525</pmid><doi>10.1016/j.crohns.2011.06.007</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Child Colitis, Ulcerative - etiology Communicable Diseases - complications Comorbidity Crohn Disease - etiology Diet Diseases in Twins - etiology Female Germany Humans Life Style Male Middle Aged Risk Factors Surveys and Questionnaires Twins, Dizygotic Twins, Monozygotic Young Adult |
| title | Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey |
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