Orchiectomy Attenuates Kidney Fibrosis after Ureteral Obstruction by Reduction of Oxidative Stress in Mice

Background/Aims: Men are generally more prone to chronic kidney disease and progression to end-stage renal disease than women. However, the underlying mechanisms remain unclear. In this study, we investigated the role of reactive oxygen species and testosterone in the progression of renal fibrosis i...

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Veröffentlicht in:	American journal of nephrology 2012-01, Vol.35 (1), p.7-16
Hauptverfasser:	Cho, Min Hyun, Jung, Kyong-Jin, Jang, Hee-Seong, Kim, Jee In, Park, Kwon Moo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Catalase - metabolism Collagen - chemistry Female Fibrosis - pathology Humans Kidney - pathology Lipid Peroxidation Male Mice Mice, Inbred C57BL Muscle, Smooth - metabolism Orchiectomy - methods Original Report: Laboratory Investigation Oxidative Stress Sex Factors Superoxide Dismutase - metabolism Ureteral Obstruction - physiopathology
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