Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck
To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer. Thirty-five patients received 6 weekly doses of carboplatin (area under the curve=2) and paclitaxel (135 mg/m) followed by concurrent weekly paclitaxel (40 mg/m) and carboplatin (area...
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| Veröffentlicht in: | American journal of clinical oncology 2012-02, Vol.35 (1), p.6-12 |
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| container_title | American journal of clinical oncology |
| container_volume | 35 |
| creator | Ready, Neal E Rathore, Ritesh Johnson, Tirrell T Nadeem, Ahmed Chougule, Prakash Ruhl, Charles Radie-Keane, Kathy Theall, Kathy Wanebo, Harold J Marcello, Jennifer Kennedy, Teresa |
| description | To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer.
Thirty-five patients received 6 weekly doses of carboplatin (area under the curve=2) and paclitaxel (135 mg/m) followed by concurrent weekly paclitaxel (40 mg/m) and carboplatin (area under the curve=1) and daily radiation (66-72 Gy).
There was 1 induction death from neutropenic sepsis and 1 sudden death during chemoradiotherapy. The overall response rate with induction was 79%. With >40 months of follow-up, the 36-month overall survival was 67% and squamous cell carcinoma of the head and neck survival 84%. Patients undergoing biopsy of the primary tumor site after the therapies had 17/18 (94%) pathologic complete response rate. The locoregional relapse rate was 40% (24 mo 28%) and distant relapse rate was 8% with only 1 distant site.
Therapy was active but patients must be carefully selected and monitored. Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control. |
| doi_str_mv | 10.1097/COC.0b013e3182019ee3 |
| format | Article |
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Thirty-five patients received 6 weekly doses of carboplatin (area under the curve=2) and paclitaxel (135 mg/m) followed by concurrent weekly paclitaxel (40 mg/m) and carboplatin (area under the curve=1) and daily radiation (66-72 Gy).
There was 1 induction death from neutropenic sepsis and 1 sudden death during chemoradiotherapy. The overall response rate with induction was 79%. With >40 months of follow-up, the 36-month overall survival was 67% and squamous cell carcinoma of the head and neck survival 84%. Patients undergoing biopsy of the primary tumor site after the therapies had 17/18 (94%) pathologic complete response rate. The locoregional relapse rate was 40% (24 mo 28%) and distant relapse rate was 8% with only 1 distant site.
Therapy was active but patients must be carefully selected and monitored. Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control.</description><identifier>ISSN: 0277-3732</identifier><identifier>EISSN: 1537-453X</identifier><identifier>DOI: 10.1097/COC.0b013e3182019ee3</identifier><identifier>PMID: 21293244</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Area Under Curve ; Carboplatin - administration & dosage ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - therapy ; Chemoradiotherapy, Adjuvant ; Drug Administration Schedule ; Female ; Head and Neck Neoplasms - drug therapy ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - radiotherapy ; Head and Neck Neoplasms - therapy ; Humans ; Induction Chemotherapy ; Male ; Middle Aged ; Neck Dissection - methods ; Neoplasm Staging ; Paclitaxel - administration & dosage ; Radiotherapy Dosage ; Treatment Outcome</subject><ispartof>American journal of clinical oncology, 2012-02, Vol.35 (1), p.6-12</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c306t-8b10e68137236aa837d7f4daa1e58d3654dbe9cffeb7e371579ba70bf1816fda3</citedby><cites>FETCH-LOGICAL-c306t-8b10e68137236aa837d7f4daa1e58d3654dbe9cffeb7e371579ba70bf1816fda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21293244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ready, Neal E</creatorcontrib><creatorcontrib>Rathore, Ritesh</creatorcontrib><creatorcontrib>Johnson, Tirrell T</creatorcontrib><creatorcontrib>Nadeem, Ahmed</creatorcontrib><creatorcontrib>Chougule, Prakash</creatorcontrib><creatorcontrib>Ruhl, Charles</creatorcontrib><creatorcontrib>Radie-Keane, Kathy</creatorcontrib><creatorcontrib>Theall, Kathy</creatorcontrib><creatorcontrib>Wanebo, Harold J</creatorcontrib><creatorcontrib>Marcello, Jennifer</creatorcontrib><creatorcontrib>Kennedy, Teresa</creatorcontrib><title>Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck</title><title>American journal of clinical oncology</title><addtitle>Am J Clin Oncol</addtitle><description>To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer.
Thirty-five patients received 6 weekly doses of carboplatin (area under the curve=2) and paclitaxel (135 mg/m) followed by concurrent weekly paclitaxel (40 mg/m) and carboplatin (area under the curve=1) and daily radiation (66-72 Gy).
There was 1 induction death from neutropenic sepsis and 1 sudden death during chemoradiotherapy. The overall response rate with induction was 79%. With >40 months of follow-up, the 36-month overall survival was 67% and squamous cell carcinoma of the head and neck survival 84%. Patients undergoing biopsy of the primary tumor site after the therapies had 17/18 (94%) pathologic complete response rate. The locoregional relapse rate was 40% (24 mo 28%) and distant relapse rate was 8% with only 1 distant site.
Therapy was active but patients must be carefully selected and monitored. Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Area Under Curve</subject><subject>Carboplatin - administration & dosage</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Induction Chemotherapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neck Dissection - methods</subject><subject>Neoplasm Staging</subject><subject>Paclitaxel - administration & dosage</subject><subject>Radiotherapy Dosage</subject><subject>Treatment Outcome</subject><issn>0277-3732</issn><issn>1537-453X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAURS0EokPhDyrkHasUvziJkyUatYA0Ujcg2EXP9rMmrWOndtIyv8OXkmFKF6ze5px3r3QZuwBxCaJTH7c320uhBUiS0JYCOiL5gm2glqqoavnzJduIUqlCKlmesTc53woh6kao1-yshLKTZVVt2O8fRHf-wCc0fpjxF3mOwXKDScfJ4zwEPgS7mHmIgZs9jXHeU8LpwF30Pj6S5frATQxmSYnCfGIS2uEZXF_4aNCvKWgfMJjVyfcLjnHJ3JD3xzQzhDgij46vGt8T2r89Apm7t-yVQ5_p3dM9Z9-vr75tvxS7m89ft592hZGimYtWg6CmBalK2SC2UlnlKosIVLdWNnVlNXXGOdKKpIJadRqV0A5aaJxFec4-nP5OKd4vlOd-HPKxHwZaq_YdKGigq8uVrE6kSTHnRK6f0jBiOvQg-uM4_TpO__84q_b-KWDRI9ln6d8a8g8FXJD3</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Ready, Neal E</creator><creator>Rathore, Ritesh</creator><creator>Johnson, Tirrell T</creator><creator>Nadeem, Ahmed</creator><creator>Chougule, Prakash</creator><creator>Ruhl, Charles</creator><creator>Radie-Keane, Kathy</creator><creator>Theall, Kathy</creator><creator>Wanebo, Harold J</creator><creator>Marcello, Jennifer</creator><creator>Kennedy, Teresa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck</title><author>Ready, Neal E ; Rathore, Ritesh ; Johnson, Tirrell T ; Nadeem, Ahmed ; Chougule, Prakash ; Ruhl, Charles ; Radie-Keane, Kathy ; Theall, Kathy ; Wanebo, Harold J ; Marcello, Jennifer ; Kennedy, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-8b10e68137236aa837d7f4daa1e58d3654dbe9cffeb7e371579ba70bf1816fda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Area Under Curve</topic><topic>Carboplatin - administration & dosage</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Induction Chemotherapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neck Dissection - methods</topic><topic>Neoplasm Staging</topic><topic>Paclitaxel - administration & dosage</topic><topic>Radiotherapy Dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ready, Neal E</creatorcontrib><creatorcontrib>Rathore, Ritesh</creatorcontrib><creatorcontrib>Johnson, Tirrell T</creatorcontrib><creatorcontrib>Nadeem, Ahmed</creatorcontrib><creatorcontrib>Chougule, Prakash</creatorcontrib><creatorcontrib>Ruhl, Charles</creatorcontrib><creatorcontrib>Radie-Keane, Kathy</creatorcontrib><creatorcontrib>Theall, Kathy</creatorcontrib><creatorcontrib>Wanebo, Harold J</creatorcontrib><creatorcontrib>Marcello, Jennifer</creatorcontrib><creatorcontrib>Kennedy, Teresa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ready, Neal E</au><au>Rathore, Ritesh</au><au>Johnson, Tirrell T</au><au>Nadeem, Ahmed</au><au>Chougule, Prakash</au><au>Ruhl, Charles</au><au>Radie-Keane, Kathy</au><au>Theall, Kathy</au><au>Wanebo, Harold J</au><au>Marcello, Jennifer</au><au>Kennedy, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck</atitle><jtitle>American journal of clinical oncology</jtitle><addtitle>Am J Clin Oncol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>35</volume><issue>1</issue><spage>6</spage><epage>12</epage><pages>6-12</pages><issn>0277-3732</issn><eissn>1537-453X</eissn><abstract>To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer.
Thirty-five patients received 6 weekly doses of carboplatin (area under the curve=2) and paclitaxel (135 mg/m) followed by concurrent weekly paclitaxel (40 mg/m) and carboplatin (area under the curve=1) and daily radiation (66-72 Gy).
There was 1 induction death from neutropenic sepsis and 1 sudden death during chemoradiotherapy. The overall response rate with induction was 79%. With >40 months of follow-up, the 36-month overall survival was 67% and squamous cell carcinoma of the head and neck survival 84%. Patients undergoing biopsy of the primary tumor site after the therapies had 17/18 (94%) pathologic complete response rate. The locoregional relapse rate was 40% (24 mo 28%) and distant relapse rate was 8% with only 1 distant site.
Therapy was active but patients must be carefully selected and monitored. Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control.</abstract><cop>United States</cop><pmid>21293244</pmid><doi>10.1097/COC.0b013e3182019ee3</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Area Under Curve Carboplatin - administration & dosage Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Chemoradiotherapy, Adjuvant Drug Administration Schedule Female Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - therapy Humans Induction Chemotherapy Male Middle Aged Neck Dissection - methods Neoplasm Staging Paclitaxel - administration & dosage Radiotherapy Dosage Treatment Outcome |
| title | Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck |
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