HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network–associated Lck signaling

The Nef protein of HIV-1 facilitates viral replication and disease progression in vivo. Nef disturbs the organization of immunological synapses between infected CD4+ T lymphocytes and antigen-presenting B-lymphocytes to interfere with TCR proximal signaling. Paradoxically, Nef enhances distal TCR si...

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Veröffentlicht in:	Blood 2012-01, Vol.119 (3), p.786-797
Hauptverfasser:	Pan, Xiaoyu, Rudolph, Jochen M., Abraham, Libin, Habermann, Anja, Haller, Claudia, Krijnse-Locker, Jacomine, Fackler, Oliver T.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - virology Cell Communication Enzyme-Linked Immunosorbent Assay HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV-1 - immunology HIV-1 - metabolism Humans Immunological Synapses - physiology Interleukin-2 - metabolism Lymphocyte Activation Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism nef Gene Products, Human Immunodeficiency Virus - immunology nef Gene Products, Human Immunodeficiency Virus - metabolism Receptors, Antigen, T-Cell Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - virology trans-Golgi Network - immunology trans-Golgi Network - metabolism trans-Golgi Network - virology Virus Replication - immunology
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