Rational Opioid Dosing in the Elderly: Dose and Dosing Interval When Initiating Opioid Therapy

Opioids are the mainstay of treatment for moderate to severe pain.1 However, opioid therapy in the elderly is often associated with significant morbidity because of excessive ventilatory depression. The large amount of interindividual variability in opioid dose–response relationships makes it diffic...

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