Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure
Background: The influence of selective serotonin reuptake inhibitors (SSRIs) on blood pressure is poorly understood. We hypothesized that if SSRIs have an influence on blood pressure, this might become manifest in changes in intraoperative blood pressure. We aimed to study the association between pe...
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| Veröffentlicht in: | American journal of hypertension 2012-02, Vol.25 (2), p.223-228 |
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| creator | Haelst, Ingrid M.M. van Klei, Wilton A. van Doodeman, Hieronymus J. Kalkman, Cor J. Egberts, Toine C.G. |
| description | Background:
The influence of selective serotonin reuptake inhibitors (SSRIs) on blood pressure is poorly understood. We hypothesized that if SSRIs have an influence on blood pressure, this might become manifest in changes in intraoperative blood pressure. We aimed to study the association between perioperative use of SSRIs and changes in intraoperative blood pressure by measuring the occurrence of intraoperative hyper- and hypotension.
Methods
We conducted a retrospective observational follow-up study among patients who underwent elective primary total hip arthroplasty. The index group included users of SSRIs. The reference group included a random sample (ratio 1:3) of nonusers of an antidepressant agent. The outcome was the occurrence of intraoperative hypo- and hypertensive episodes (number, mean and total duration, and area under the curve (AUC)). The outcome was adjusted for confounding factors using regression techniques.
Results
The index group included 20 users of an SSRI. The reference group included 60 nonusers. Users of SSRIs showed fewer intraoperative hypotensive episodes, a shorter mean and total duration, and a smaller AUC when compared to the reference group. After adjustment for confounders, SSRI use was associated with a significantly shorter total duration of hypotension: mean difference of −29.4 min (95% confidence interval (CI) −50.4 to −8.3). Two users of an SSRI and two patients in the reference group had a hypertensive episode.
Conclusions
Continuation of treatment with SSRIs before surgery was associated with a briefer duration of intraoperative hypotension. |
| doi_str_mv | 10.1038/ajh.2011.194 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_917160730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1038/ajh.2011.194</oup_id><sourcerecordid>2570853241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-5c5e403d3fac3d4ccbf8a0aa1a81599fdcb2b282f195e991ec592f8115cb0e903</originalsourceid><addsrcrecordid>eNp90M9LwzAUB_AgipvTm2cpgnixMy9t2uaowx8DQXF6Lmn6wjq7piat4H9v5qYDDx6SEPi895IvIcdAx0Cj7FIu5mNGAcYg4h0y9DuEKWN8lwxpJniY0gQG5MC5BaU0ThLYJwPmC_xKh2Q6wxpVV31gMENrOtNUTfCMfdvJNwymzbwqqs5YF8im9NfOStOild8F17UxZfBk0bne4iHZ07J2eLQ5R-T19uZlch8-PN5NJ1cPoYoh7UKuOMY0KiMtVVTGShU6k1RKkBlwIXSpClawjGkQHIUAVFwwnQFwVVAUNBqR83Xf1pr3Hl2XLyunsK5lg6Z3uYAUEppGK3n6Ry5Mbxv_uBUSjEcs8ehijZQ1zlnUeWurpbSfOdB8FXDuA85XAec-Ws9PNj37YonlL_5J1IOzDZBOyVpb2ajKbR1P4iijbPsN07f_j_wCx2iPfQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>917925326</pqid></control><display><type>article</type><title>Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Haelst, Ingrid M.M. van ; Klei, Wilton A. van ; Doodeman, Hieronymus J. ; Kalkman, Cor J. ; Egberts, Toine C.G.</creator><creatorcontrib>Haelst, Ingrid M.M. van ; Klei, Wilton A. van ; Doodeman, Hieronymus J. ; Kalkman, Cor J. ; Egberts, Toine C.G.</creatorcontrib><description>Background:
The influence of selective serotonin reuptake inhibitors (SSRIs) on blood pressure is poorly understood. We hypothesized that if SSRIs have an influence on blood pressure, this might become manifest in changes in intraoperative blood pressure. We aimed to study the association between perioperative use of SSRIs and changes in intraoperative blood pressure by measuring the occurrence of intraoperative hyper- and hypotension.
Methods
We conducted a retrospective observational follow-up study among patients who underwent elective primary total hip arthroplasty. The index group included users of SSRIs. The reference group included a random sample (ratio 1:3) of nonusers of an antidepressant agent. The outcome was the occurrence of intraoperative hypo- and hypertensive episodes (number, mean and total duration, and area under the curve (AUC)). The outcome was adjusted for confounding factors using regression techniques.
Results
The index group included 20 users of an SSRI. The reference group included 60 nonusers. Users of SSRIs showed fewer intraoperative hypotensive episodes, a shorter mean and total duration, and a smaller AUC when compared to the reference group. After adjustment for confounders, SSRI use was associated with a significantly shorter total duration of hypotension: mean difference of −29.4 min (95% confidence interval (CI) −50.4 to −8.3). Two users of an SSRI and two patients in the reference group had a hypertensive episode.
Conclusions
Continuation of treatment with SSRIs before surgery was associated with a briefer duration of intraoperative hypotension.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1038/ajh.2011.194</identifier><identifier>PMID: 22012207</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Antidepressive Agents, Second-Generation - administration & dosage ; Antidepressive Agents, Second-Generation - adverse effects ; Arterial hypertension. Arterial hypotension ; Arthroplasty, Replacement, Hip ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Follow-Up Studies ; Humans ; Hypertension - chemically induced ; Hypertension - epidemiology ; Hypotension - chemically induced ; Hypotension - epidemiology ; Intraoperative Complications - chemically induced ; Intraoperative Complications - epidemiology ; Male ; Medical sciences ; Middle Aged ; Monitoring, Intraoperative ; Retrospective Studies ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - adverse effects</subject><ispartof>American journal of hypertension, 2012-02, Vol.25 (2), p.223-228</ispartof><rights>American Journal of Hypertension, Ltd. © 2012 by the American Journal of Hypertension, Ltd. 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-5c5e403d3fac3d4ccbf8a0aa1a81599fdcb2b282f195e991ec592f8115cb0e903</citedby><cites>FETCH-LOGICAL-c417t-5c5e403d3fac3d4ccbf8a0aa1a81599fdcb2b282f195e991ec592f8115cb0e903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25643802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22012207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haelst, Ingrid M.M. van</creatorcontrib><creatorcontrib>Klei, Wilton A. van</creatorcontrib><creatorcontrib>Doodeman, Hieronymus J.</creatorcontrib><creatorcontrib>Kalkman, Cor J.</creatorcontrib><creatorcontrib>Egberts, Toine C.G.</creatorcontrib><title>Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Background:
The influence of selective serotonin reuptake inhibitors (SSRIs) on blood pressure is poorly understood. We hypothesized that if SSRIs have an influence on blood pressure, this might become manifest in changes in intraoperative blood pressure. We aimed to study the association between perioperative use of SSRIs and changes in intraoperative blood pressure by measuring the occurrence of intraoperative hyper- and hypotension.
Methods
We conducted a retrospective observational follow-up study among patients who underwent elective primary total hip arthroplasty. The index group included users of SSRIs. The reference group included a random sample (ratio 1:3) of nonusers of an antidepressant agent. The outcome was the occurrence of intraoperative hypo- and hypertensive episodes (number, mean and total duration, and area under the curve (AUC)). The outcome was adjusted for confounding factors using regression techniques.
Results
The index group included 20 users of an SSRI. The reference group included 60 nonusers. Users of SSRIs showed fewer intraoperative hypotensive episodes, a shorter mean and total duration, and a smaller AUC when compared to the reference group. After adjustment for confounders, SSRI use was associated with a significantly shorter total duration of hypotension: mean difference of −29.4 min (95% confidence interval (CI) −50.4 to −8.3). Two users of an SSRI and two patients in the reference group had a hypertensive episode.
Conclusions
Continuation of treatment with SSRIs before surgery was associated with a briefer duration of intraoperative hypotension.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antidepressive Agents, Second-Generation - administration & dosage</subject><subject>Antidepressive Agents, Second-Generation - adverse effects</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - chemically induced</subject><subject>Hypertension - epidemiology</subject><subject>Hypotension - chemically induced</subject><subject>Hypotension - epidemiology</subject><subject>Intraoperative Complications - chemically induced</subject><subject>Intraoperative Complications - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Intraoperative</subject><subject>Retrospective Studies</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - adverse effects</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90M9LwzAUB_AgipvTm2cpgnixMy9t2uaowx8DQXF6Lmn6wjq7piat4H9v5qYDDx6SEPi895IvIcdAx0Cj7FIu5mNGAcYg4h0y9DuEKWN8lwxpJniY0gQG5MC5BaU0ThLYJwPmC_xKh2Q6wxpVV31gMENrOtNUTfCMfdvJNwymzbwqqs5YF8im9NfOStOild8F17UxZfBk0bne4iHZ07J2eLQ5R-T19uZlch8-PN5NJ1cPoYoh7UKuOMY0KiMtVVTGShU6k1RKkBlwIXSpClawjGkQHIUAVFwwnQFwVVAUNBqR83Xf1pr3Hl2XLyunsK5lg6Z3uYAUEppGK3n6Ry5Mbxv_uBUSjEcs8ehijZQ1zlnUeWurpbSfOdB8FXDuA85XAec-Ws9PNj37YonlL_5J1IOzDZBOyVpb2ajKbR1P4iijbPsN07f_j_wCx2iPfQ</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Haelst, Ingrid M.M. van</creator><creator>Klei, Wilton A. van</creator><creator>Doodeman, Hieronymus J.</creator><creator>Kalkman, Cor J.</creator><creator>Egberts, Toine C.G.</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure</title><author>Haelst, Ingrid M.M. van ; Klei, Wilton A. van ; Doodeman, Hieronymus J. ; Kalkman, Cor J. ; Egberts, Toine C.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-5c5e403d3fac3d4ccbf8a0aa1a81599fdcb2b282f195e991ec592f8115cb0e903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antidepressive Agents, Second-Generation - administration & dosage</topic><topic>Antidepressive Agents, Second-Generation - adverse effects</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - chemically induced</topic><topic>Hypertension - epidemiology</topic><topic>Hypotension - chemically induced</topic><topic>Hypotension - epidemiology</topic><topic>Intraoperative Complications - chemically induced</topic><topic>Intraoperative Complications - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Intraoperative</topic><topic>Retrospective Studies</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haelst, Ingrid M.M. van</creatorcontrib><creatorcontrib>Klei, Wilton A. van</creatorcontrib><creatorcontrib>Doodeman, Hieronymus J.</creatorcontrib><creatorcontrib>Kalkman, Cor J.</creatorcontrib><creatorcontrib>Egberts, Toine C.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haelst, Ingrid M.M. van</au><au>Klei, Wilton A. van</au><au>Doodeman, Hieronymus J.</au><au>Kalkman, Cor J.</au><au>Egberts, Toine C.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>25</volume><issue>2</issue><spage>223</spage><epage>228</epage><pages>223-228</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Background:
The influence of selective serotonin reuptake inhibitors (SSRIs) on blood pressure is poorly understood. We hypothesized that if SSRIs have an influence on blood pressure, this might become manifest in changes in intraoperative blood pressure. We aimed to study the association between perioperative use of SSRIs and changes in intraoperative blood pressure by measuring the occurrence of intraoperative hyper- and hypotension.
Methods
We conducted a retrospective observational follow-up study among patients who underwent elective primary total hip arthroplasty. The index group included users of SSRIs. The reference group included a random sample (ratio 1:3) of nonusers of an antidepressant agent. The outcome was the occurrence of intraoperative hypo- and hypertensive episodes (number, mean and total duration, and area under the curve (AUC)). The outcome was adjusted for confounding factors using regression techniques.
Results
The index group included 20 users of an SSRI. The reference group included 60 nonusers. Users of SSRIs showed fewer intraoperative hypotensive episodes, a shorter mean and total duration, and a smaller AUC when compared to the reference group. After adjustment for confounders, SSRI use was associated with a significantly shorter total duration of hypotension: mean difference of −29.4 min (95% confidence interval (CI) −50.4 to −8.3). Two users of an SSRI and two patients in the reference group had a hypertensive episode.
Conclusions
Continuation of treatment with SSRIs before surgery was associated with a briefer duration of intraoperative hypotension.</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>22012207</pmid><doi>10.1038/ajh.2011.194</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Antidepressive Agents, Second-Generation - administration & dosage Antidepressive Agents, Second-Generation - adverse effects Arterial hypertension. Arterial hypotension Arthroplasty, Replacement, Hip Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Follow-Up Studies Humans Hypertension - chemically induced Hypertension - epidemiology Hypotension - chemically induced Hypotension - epidemiology Intraoperative Complications - chemically induced Intraoperative Complications - epidemiology Male Medical sciences Middle Aged Monitoring, Intraoperative Retrospective Studies Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - adverse effects |
| title | Selective Serotonin Reuptake Inhibitors and Intraoperative Blood Pressure |
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