Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease

Two histidine-rich branched peptides with one lysine as a branching unit have been designed and synthesized by solid-phase peptide synthesis. Their complex formation with Cu(II) and Zn(II) as well as their ability to attenuate the metal-ion induced amyloid aggregation has been characterized. Both pe...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2012-02, Vol.41 (6), p.1713-1726
Hauptverfasser:	Lakatos, Andrea, Gyurcsik, Béla, Nagy, Nóra V, Csendes, Zita, Wéber, Edit, Fülöp, Lívia, Kiss, Tamás
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Chelating Agents - chemistry Chelating Agents - pharmacology Copper - chemistry Histidine - chemistry Histidine - pharmacology Humans Peptides - chemistry Peptides - pharmacology Zinc - chemistry
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