Nicotine reduces VEGF-secretion and phagocytotic activity in porcine RPE

Background/Purpose Smoking is a strong environmental factor for the development of age-related macula degeneration. In this study, we investigated the effects of nicotine on RPE cell function in porcine in vitro models, focussing on cell death, VEGF secretion and phagocytotic ability. Methods For th...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2012, Vol.250 (1), p.33-38
Hauptverfasser:	Klettner, Alexa Karina, Doths, Johanna, Roider, Johann
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal models Animals Apoptosis Atrophy Basic Science Cell culture Cell death Cell Survival Cells, Cultured Degeneration Environmental factors Enzyme-Linked Immunosorbent Assay Latex beads Medicine Medicine & Public Health Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Ophthalmology Organ culture Organ Culture Techniques Perfusion Phagocytosis Phagocytosis - physiology Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Secretion Smoking Swine Tetrazolium Salts - metabolism Thiazoles - metabolism Trypan Blue - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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