Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery
For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk. Patients referred for coronary revascul...
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| Veröffentlicht in: | The New England journal of medicine 2012-01, Vol.366 (3), p.250-257 |
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| container_title | The New England journal of medicine |
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| creator | Selnes, Ola A Gottesman, Rebecca F Grega, Maura A Baumgartner, William A Zeger, Scott L McKhann, Guy M |
| description | For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk.
Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent procedures, have continued to decline.
1
Nevertheless, adverse neurologic outcomes, including stroke and cognitive decline, remain a major concern for these older patients.
The development of strategies to reduce the incidence of postoperative neurologic events has been hampered by the lack of a clear understanding of the pathophysiology of such outcomes. Owing partly to the assumption that adverse neurologic events were specifically . . . |
| doi_str_mv | 10.1056/NEJMra1100109 |
| format | Article |
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Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent procedures, have continued to decline.
1
Nevertheless, adverse neurologic outcomes, including stroke and cognitive decline, remain a major concern for these older patients.
The development of strategies to reduce the incidence of postoperative neurologic events has been hampered by the lack of a clear understanding of the pathophysiology of such outcomes. Owing partly to the assumption that adverse neurologic events were specifically . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMra1100109</identifier><identifier>PMID: 22256807</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognitive ability ; Coronary artery ; Coronary Artery Bypass ; Coronary heart disease ; General aspects ; Heart ; Heart surgery ; Humans ; Hypertension ; Incidence ; Medical sciences ; Monitoring, Intraoperative ; Mortality ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Older people ; Patients ; Postoperative Complications - diagnosis ; Stroke - etiology ; Stroke - physiopathology ; Stroke - prevention & control ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart</subject><ispartof>The New England journal of medicine, 2012-01, Vol.366 (3), p.250-257</ispartof><rights>Copyright © 2012 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c294t-2d0ee18c23299577acac14df3a7a705dc781e7324785c34ce252041f672a24653</citedby><cites>FETCH-LOGICAL-c294t-2d0ee18c23299577acac14df3a7a705dc781e7324785c34ce252041f672a24653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMra1100109$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/916910968?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25476560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22256807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selnes, Ola A</creatorcontrib><creatorcontrib>Gottesman, Rebecca F</creatorcontrib><creatorcontrib>Grega, Maura A</creatorcontrib><creatorcontrib>Baumgartner, William A</creatorcontrib><creatorcontrib>Zeger, Scott L</creatorcontrib><creatorcontrib>McKhann, Guy M</creatorcontrib><title>Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk.
Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent procedures, have continued to decline.
1
Nevertheless, adverse neurologic outcomes, including stroke and cognitive decline, remain a major concern for these older patients.
The development of strategies to reduce the incidence of postoperative neurologic events has been hampered by the lack of a clear understanding of the pathophysiology of such outcomes. Owing partly to the assumption that adverse neurologic events were specifically . . .</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive ability</subject><subject>Coronary artery</subject><subject>Coronary Artery Bypass</subject><subject>Coronary heart disease</subject><subject>General aspects</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Medical sciences</subject><subject>Monitoring, Intraoperative</subject><subject>Mortality</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older people</subject><subject>Patients</subject><subject>Postoperative Complications - diagnosis</subject><subject>Stroke - etiology</subject><subject>Stroke - physiopathology</subject><subject>Stroke - prevention & control</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Vascular system</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive ability</topic><topic>Coronary artery</topic><topic>Coronary Artery Bypass</topic><topic>Coronary heart disease</topic><topic>General aspects</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Medical sciences</topic><topic>Monitoring, Intraoperative</topic><topic>Mortality</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Older people</topic><topic>Patients</topic><topic>Postoperative Complications - diagnosis</topic><topic>Stroke - etiology</topic><topic>Stroke - physiopathology</topic><topic>Stroke - prevention & control</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selnes, Ola A</creatorcontrib><creatorcontrib>Gottesman, Rebecca F</creatorcontrib><creatorcontrib>Grega, Maura A</creatorcontrib><creatorcontrib>Baumgartner, William A</creatorcontrib><creatorcontrib>Zeger, Scott L</creatorcontrib><creatorcontrib>McKhann, Guy M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selnes, Ola A</au><au>Gottesman, Rebecca F</au><au>Grega, Maura A</au><au>Baumgartner, William A</au><au>Zeger, Scott L</au><au>McKhann, Guy M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2012-01-19</date><risdate>2012</risdate><volume>366</volume><issue>3</issue><spage>250</spage><epage>257</epage><pages>250-257</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk.
Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent procedures, have continued to decline.
1
Nevertheless, adverse neurologic outcomes, including stroke and cognitive decline, remain a major concern for these older patients.
The development of strategies to reduce the incidence of postoperative neurologic events has been hampered by the lack of a clear understanding of the pathophysiology of such outcomes. Owing partly to the assumption that adverse neurologic events were specifically . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>22256807</pmid><doi>10.1056/NEJMra1100109</doi><tpages>8</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 2012-01, Vol.366 (3), p.250-257 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Biological and medical sciences Cardiology. Vascular system Cognition Disorders - diagnosis Cognition Disorders - etiology Cognitive ability Coronary artery Coronary Artery Bypass Coronary heart disease General aspects Heart Heart surgery Humans Hypertension Incidence Medical sciences Monitoring, Intraoperative Mortality Neuropsychological Tests NMR Nuclear magnetic resonance Older people Patients Postoperative Complications - diagnosis Stroke - etiology Stroke - physiopathology Stroke - prevention & control Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart |
| title | Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery |
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