Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers
Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new st...
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| Veröffentlicht in: | Journal of the American Chemical Society 2012-01, Vol.134 (2), p.754-757 |
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| container_end_page | 757 |
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| container_issue | 2 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 134 |
| creator | Schmitt, Frédéric Freudenreich, Julien Barry, Nicolas P. E Juillerat-Jeanneret, Lucienne Süss-Fink, Georg Therrien, Bruno |
| description | Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic therapy. |
| doi_str_mv | 10.1021/ja207784t |
| format | Article |
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| ispartof | Journal of the American Chemical Society, 2012-01, Vol.134 (2), p.754-757 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Drug Delivery Systems HeLa Cells Humans Models, Molecular Molecular Biology Organometallic Compounds - chemistry Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Porphyrins - chemistry Porphyrins - pharmacology |
| title | Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers |
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