Preventive Effects of Exenatide on Endothelial Dysfunction Induced by Ischemia-Reperfusion Injury via KATP Channels

OBJECTIVE—The purpose of this study was to evaluate whether exenatide administration can prevent impairment in endothelium-dependent vasodilatation induced by ischemia-reperfusion (IR) injury and whether this effect is mediated by KATP channel opening. METHODS AND RESULTS—In a double-blind, placebo-...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.474-480
Hauptverfasser:	Ha, Sang Jin, Kim, Weon, Woo, Jong Shin, Kim, Jin Bae, Kim, Soo Joong, Kim, Woo-Shik, Kim, Myeong Kon, Cheng, Xian Wu, Kim, Kwon Sam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Brachial Artery - physiopathology Cardiology. Vascular system Cardiovascular system Cross-Over Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Forearm - blood supply Glyburide - pharmacology Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Injections, Subcutaneous KATP Channels - drug effects KATP Channels - physiology Medical sciences Peptides - administration & dosage Peptides - pharmacology Pharmacology. Drug treatments Potassium Channel Blockers - pharmacology Reperfusion Injury - complications Vasodilation - physiology Vasodilator agents. Cerebral vasodilators Venoms - administration & dosage Venoms - pharmacology
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