Relationship between Periodontal Status and Levels of Glycated Hemoglobin
The objective of this study was to assess whether there is a bi-directional relationship between periodontal status and diabetes. Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CP...
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| Veröffentlicht in: | Journal of dental research 2012-02, Vol.91 (2), p.161-166 |
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| container_title | Journal of dental research |
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| creator | Morita, I. Inagaki, K. Nakamura, F. Noguchi, T. Matsubara, T. Yoshii, S. Nakagaki, H. Mizuno, K. Sheiham, A. Sabbah, W. |
| description | The objective of this study was to assess whether there is a bi-directional relationship between periodontal status and diabetes. Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CPI scores 3 and 4, with the CPI probe), in individuals with glycated hemoglobin (HbA1c) levels of ≥ 6.5% at baseline. Study 2 included 6,125 people with HbA1c < 6.5% at baseline. The relative risk was assessed for elevation of HbA1c levels in 5 years, with baseline periodontal status, assessed by CPI. Relative risk of developing a periodontal pocket was 1.17 (p = 0.038) times greater in those with HbA1c of ≥ 6.5% at baseline, adjusted for body mass index (BMI), smoking status, sex, and age. Relative risks for having HbA1c ≥ 6.5% at 5-year follow-up in groups with periodontal pockets of 4 to 5 mm and ≥ 6 mm at baseline were 2.47 (p = 0.122) and 3.45 (p = 0.037), respectively, adjusted for BMI, alcohol consumption, smoking status, sex, and age. The risk of developing periodontal disease was associated with levels of HbA1c, and the risk of elevations of HbA1c was associated with developing periodontal pockets of more than 4 mm. |
| doi_str_mv | 10.1177/0022034511431583 |
| format | Article |
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Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CPI scores 3 and 4, with the CPI probe), in individuals with glycated hemoglobin (HbA1c) levels of ≥ 6.5% at baseline. Study 2 included 6,125 people with HbA1c < 6.5% at baseline. The relative risk was assessed for elevation of HbA1c levels in 5 years, with baseline periodontal status, assessed by CPI. Relative risk of developing a periodontal pocket was 1.17 (p = 0.038) times greater in those with HbA1c of ≥ 6.5% at baseline, adjusted for body mass index (BMI), smoking status, sex, and age. Relative risks for having HbA1c ≥ 6.5% at 5-year follow-up in groups with periodontal pockets of 4 to 5 mm and ≥ 6 mm at baseline were 2.47 (p = 0.122) and 3.45 (p = 0.037), respectively, adjusted for BMI, alcohol consumption, smoking status, sex, and age. The risk of developing periodontal disease was associated with levels of HbA1c, and the risk of elevations of HbA1c was associated with developing periodontal pockets of more than 4 mm.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/0022034511431583</identifier><identifier>PMID: 22157098</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Age Factors ; Aged ; Alcohol Drinking - epidemiology ; Body Mass Index ; Case-Control Studies ; Cohort Studies ; Dental Calculus - epidemiology ; Dentistry ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Follow-Up Studies ; Gingival Hemorrhage - epidemiology ; Glycated Hemoglobin A - analysis ; Humans ; Incidence ; Japan - epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Obesity - epidemiology ; Periodontal Index ; Periodontal Pocket - classification ; Periodontal Pocket - epidemiology ; Prospective Studies ; Risk Assessment ; Sex Factors ; Smoking - epidemiology</subject><ispartof>Journal of dental research, 2012-02, Vol.91 (2), p.161-166</ispartof><rights>2012 International & American Associations for Dental Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-6f96132e73a2c120dbfe9df252151a44ef1dc76f8cc95671a03c95509d93e27f3</citedby><cites>FETCH-LOGICAL-c402t-6f96132e73a2c120dbfe9df252151a44ef1dc76f8cc95671a03c95509d93e27f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0022034511431583$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0022034511431583$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22157098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morita, I.</creatorcontrib><creatorcontrib>Inagaki, K.</creatorcontrib><creatorcontrib>Nakamura, F.</creatorcontrib><creatorcontrib>Noguchi, T.</creatorcontrib><creatorcontrib>Matsubara, T.</creatorcontrib><creatorcontrib>Yoshii, S.</creatorcontrib><creatorcontrib>Nakagaki, H.</creatorcontrib><creatorcontrib>Mizuno, K.</creatorcontrib><creatorcontrib>Sheiham, A.</creatorcontrib><creatorcontrib>Sabbah, W.</creatorcontrib><title>Relationship between Periodontal Status and Levels of Glycated Hemoglobin</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>The objective of this study was to assess whether there is a bi-directional relationship between periodontal status and diabetes. Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CPI scores 3 and 4, with the CPI probe), in individuals with glycated hemoglobin (HbA1c) levels of ≥ 6.5% at baseline. Study 2 included 6,125 people with HbA1c < 6.5% at baseline. The relative risk was assessed for elevation of HbA1c levels in 5 years, with baseline periodontal status, assessed by CPI. Relative risk of developing a periodontal pocket was 1.17 (p = 0.038) times greater in those with HbA1c of ≥ 6.5% at baseline, adjusted for body mass index (BMI), smoking status, sex, and age. Relative risks for having HbA1c ≥ 6.5% at 5-year follow-up in groups with periodontal pockets of 4 to 5 mm and ≥ 6 mm at baseline were 2.47 (p = 0.122) and 3.45 (p = 0.037), respectively, adjusted for BMI, alcohol consumption, smoking status, sex, and age. The risk of developing periodontal disease was associated with levels of HbA1c, and the risk of elevations of HbA1c was associated with developing periodontal pockets of more than 4 mm.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Dental Calculus - epidemiology</subject><subject>Dentistry</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gingival Hemorrhage - epidemiology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - epidemiology</subject><subject>Periodontal Index</subject><subject>Periodontal Pocket - classification</subject><subject>Periodontal Pocket - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Factors</subject><subject>Smoking - epidemiology</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAQxS0EoqWwM6FsTAGfHSfxiCpoK1UC8TFHjnMuqZy4xA6o_z2pWhiQmO6k-72ne4-QS6A3AFl2SyljlCcCIOEgcn5ExiCSJKZCwjEZ787x7j4iZ96vKQXJcn5KRoyByKjMx2TxjFaF2rX-vd5EJYYvxDZ6wq52lWuDstFLUKH3kWqraImfaH3kTDSzW60CVtEcG7eyrqzbc3JilPV4cZgT8vZw_zqdx8vH2WJ6t4x1QlmIUyNT4AwzrpgGRqvSoKwME8NLoJIEDVQ6S02utRRpBoryYRFUVpIjywyfkOu976ZzHz36UDS112itatH1vpCQDeFygIGke1J3zvsOTbHp6kZ12wJoseuv-NvfILk6mPdlg9Wv4KewAYj3gFcrLNau79oh7P-G31R0ds4</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Morita, I.</creator><creator>Inagaki, K.</creator><creator>Nakamura, F.</creator><creator>Noguchi, T.</creator><creator>Matsubara, T.</creator><creator>Yoshii, S.</creator><creator>Nakagaki, H.</creator><creator>Mizuno, K.</creator><creator>Sheiham, A.</creator><creator>Sabbah, W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Relationship between Periodontal Status and Levels of Glycated Hemoglobin</title><author>Morita, I. ; Inagaki, K. ; Nakamura, F. ; Noguchi, T. ; Matsubara, T. ; Yoshii, S. ; Nakagaki, H. ; Mizuno, K. ; Sheiham, A. ; Sabbah, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-6f96132e73a2c120dbfe9df252151a44ef1dc76f8cc95671a03c95509d93e27f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Dental Calculus - epidemiology</topic><topic>Dentistry</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gingival Hemorrhage - epidemiology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - epidemiology</topic><topic>Periodontal Index</topic><topic>Periodontal Pocket - classification</topic><topic>Periodontal Pocket - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Factors</topic><topic>Smoking - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morita, I.</creatorcontrib><creatorcontrib>Inagaki, K.</creatorcontrib><creatorcontrib>Nakamura, F.</creatorcontrib><creatorcontrib>Noguchi, T.</creatorcontrib><creatorcontrib>Matsubara, T.</creatorcontrib><creatorcontrib>Yoshii, S.</creatorcontrib><creatorcontrib>Nakagaki, H.</creatorcontrib><creatorcontrib>Mizuno, K.</creatorcontrib><creatorcontrib>Sheiham, A.</creatorcontrib><creatorcontrib>Sabbah, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morita, I.</au><au>Inagaki, K.</au><au>Nakamura, F.</au><au>Noguchi, T.</au><au>Matsubara, T.</au><au>Yoshii, S.</au><au>Nakagaki, H.</au><au>Mizuno, K.</au><au>Sheiham, A.</au><au>Sabbah, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Periodontal Status and Levels of Glycated Hemoglobin</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>91</volume><issue>2</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>The objective of this study was to assess whether there is a bi-directional relationship between periodontal status and diabetes. Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CPI scores 3 and 4, with the CPI probe), in individuals with glycated hemoglobin (HbA1c) levels of ≥ 6.5% at baseline. Study 2 included 6,125 people with HbA1c < 6.5% at baseline. The relative risk was assessed for elevation of HbA1c levels in 5 years, with baseline periodontal status, assessed by CPI. Relative risk of developing a periodontal pocket was 1.17 (p = 0.038) times greater in those with HbA1c of ≥ 6.5% at baseline, adjusted for body mass index (BMI), smoking status, sex, and age. Relative risks for having HbA1c ≥ 6.5% at 5-year follow-up in groups with periodontal pockets of 4 to 5 mm and ≥ 6 mm at baseline were 2.47 (p = 0.122) and 3.45 (p = 0.037), respectively, adjusted for BMI, alcohol consumption, smoking status, sex, and age. The risk of developing periodontal disease was associated with levels of HbA1c, and the risk of elevations of HbA1c was associated with developing periodontal pockets of more than 4 mm.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22157098</pmid><doi>10.1177/0022034511431583</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Alcohol Drinking - epidemiology Body Mass Index Case-Control Studies Cohort Studies Dental Calculus - epidemiology Dentistry Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Female Follow-Up Studies Gingival Hemorrhage - epidemiology Glycated Hemoglobin A - analysis Humans Incidence Japan - epidemiology Longitudinal Studies Male Middle Aged Obesity - epidemiology Periodontal Index Periodontal Pocket - classification Periodontal Pocket - epidemiology Prospective Studies Risk Assessment Sex Factors Smoking - epidemiology |
| title | Relationship between Periodontal Status and Levels of Glycated Hemoglobin |
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