Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration

Hematopoietic stem cells (HSCs) can regenerate the entire hematopoietic system in vivo, providing the most relevant criteria to measure candidate HSCs derived from human embryonic stem cell (hESC) or induced pluripotent stem cell (hiPSC) sources. Here we show that, unlike primitive hematopoietic cel...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2012-02, Vol.30 (2), p.131-139
Hauptverfasser:	Risueño, Ruth M., Sachlos, Eleftherios, Lee, Jong-Hee, Lee, Jung Bok, Hong, Seok-Ho, Szabo, Eva, Bhatia, Mickie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - metabolism Bone marrow Bone Marrow - physiology Bone Marrow Cells Cell Differentiation Cell Proliferation Cells, Cultured Differentiation Down-Regulation Embryonic Stem Cells - metabolism Embryonic Stem Cells - physiology Gene Expression Profiling Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Hemopoietic stem cells Humans Induced pluripotent stem cells Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - physiology Induced Pluripotent Stem Cells - transplantation Mice Mice, Inbred NOD Mice, SCID MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Regeneration Stem cells Transplantation, Heterologous Transplants & implants Xenogeneic stem cell transplantation
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