Synthesis of Lipophilic Genistein Derivatives and Their Regulation of IL-12 and TNF-α in Activated J774A.1 Cells

Genistein modulates inflammatory responses in part by reducing the production of the pro‐inflammatory cytokines IL‐12, TNF‐α, and nitric oxide, by activated macrophages in response to lipopolysaccharide stimulus. Previous studies have shown that synthetic lipophilic genistein glycosides were signifi...

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Veröffentlicht in:	Chemical biology & drug design 2012-03, Vol.79 (3), p.347-352
Hauptverfasser:	Castro, Sandra B. R., Junior, Celso O. R., Alves, Caio C. S., Dias, Alyria T., Alves, Lívia L., Mazzoccoli, Luciano, Zoet, Mateus T., Fernandes, Sérgio A., Teixeira, Henrique C., Almeida, Mauro V., Ferreira, Ana Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	acylation Animals Cell Line cytokines etherification Gene Expression Regulation - drug effects genistein Genistein - analogs & derivatives Genistein - chemical synthesis Genistein - pharmacology Interleukin-12 - metabolism Lipopolysaccharides - toxicity Mice nitric oxide Nitric Oxide - metabolism Tumor Necrosis Factor-alpha - metabolism
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