LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation

Background and objective. Mutations in the Leucine‐Rich Repeat Kinase 2 (LRRK2) gene at chromosome 12q12 are the most common genetic cause of sporadic and familial late‐onset Parkinson's disease. Our aim was to identify novel LRRK2 mutations in late‐onset Parkinson's disease families. Desi...

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Veröffentlicht in:	Movement disorders 2012-01, Vol.27 (1), p.146-150
Hauptverfasser:	Lorenzo-Betancor, Oswaldo, Samaranch, Lluís, Ezquerra, Mario, Tolosa, Eduardo, Lorenzo, Elena, Irigoyen, Jaione, Gaig, Carles, Pastor, María A., Soto-Ortolaza, Alexandra I., Ross, Owen A., Rodríguez-Oroz, María C., Valldeoriola, Francesc, Martí, María J., Luquin, María R., Perez-Tur, Jordi, Burguera, Juan A., Obeso, José A., Pastor, Pau
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Arginine - genetics Chromosomes, Human, Pair 12 Dardarin DNA Mutational Analysis Family Health Female Genetic Linkage genetics haplotype Haplotypes Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 Male Middle Aged mutation Mutation - genetics Parkinson Disease - genetics Parkinson's disease Protein-Serine-Threonine Kinases - genetics Serine - genetics
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