Lithiation-Electrophilic Substitution of N-Thiopivaloylazetidine

Lithiation-Electrophilic Substitution of N-Thiopivaloylazetidine

The fourth protocol: The rarely studied N‐thiopivaloyl group plays a crucial role in mediating efficient α lithiation and incorporation of diverse electrophiles onto an azetidine ring; in the presence of chiral ligands, this chemistry also provides the first example of an enantioselective electrophi...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-04, Vol.49 (16), p.2900-2903
Hauptverfasser: Hodgson, David M, Kloesges, Johannes
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Sprache:eng
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asymmetric synthesis
azetidines
electrophilic substitution
lithiation
synthetic methods
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creator Hodgson, David M
Kloesges, Johannes
description The fourth protocol: The rarely studied N‐thiopivaloyl group plays a crucial role in mediating efficient α lithiation and incorporation of diverse electrophiles onto an azetidine ring; in the presence of chiral ligands, this chemistry also provides the first example of an enantioselective electrophilic substitution on a four‐membered ring.
doi_str_mv 10.1002/anie.201000058
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source Wiley Online Library Journals Frontfile Complete
subjects asymmetric synthesis
azetidines
electrophilic substitution
lithiation
synthetic methods
title Lithiation-Electrophilic Substitution of N-Thiopivaloylazetidine
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