Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation

The aim of this research was to investigate the effect of caffeine on band 3 (the anion exchanger protein), haemoglobin function, caspase 3 activation and glucose-6-phosphate metabolism during the oxygenation–deoxygenation cycle in human red blood cells. A particular attention has been given to the...

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Veröffentlicht in:	Biochimie 2012-02, Vol.94 (2), p.393-402
Hauptverfasser:	Tellone, Ester, Ficarra, Silvana, Russo, Annamaria, Bellocco, Ersilia, Barreca, Davide, Laganà, Giuseppina, Leuzzi, Ugo, Pirolli, Davide, Cristina De Rosa, Maria, Giardina, Bruno, Galtieri, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anion Exchange Protein 1, Erythrocyte - agonists Anion Exchange Protein 1, Erythrocyte - metabolism Band 3 protein Binding Sites Biological Transport - drug effects Caffeine - pharmacology Caspase 3 Caspase 3 - metabolism Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Haemoglobin Heme - metabolism Hemoglobins - chemistry Hemoglobins - metabolism Humans Hydroxyl Radical - antagonists & inhibitors Hydroxyl Radical - metabolism Kinetics Metabolism Models, Molecular NADP - biosynthesis Oxidation-Reduction Oxygen - metabolism Pentose Phosphate Pathway - drug effects Protein Binding - drug effects Protein Conformation Thermodynamics
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