RON is associated with tumor progression via the inhibition of apoptosis and cell cycle arrest in human gastric cancer

The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed in epithelial cancers, including gastric cancer. The aims of the present study were to evaluate whether RON affects tumor cell behaviors and oncogenic signaling pathways, and to document the relationship of its expr...

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Veröffentlicht in:	Pathology international 2012-02, Vol.62 (2), p.127-136
Hauptverfasser:	Song, Young-A., Park, Young-Lan, Kim, Kyu-Yeol, Myung, Eun, Chung, Cho-Yun, Cho, Sung-Bum, Lee, Wan-Sik, Jung, Young-Do, Kweon, Sun-Seog, Joo, Young-Eun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over AKT protein Apoptosis Apoptosis - genetics Cell cycle Cell Cycle Checkpoints - genetics Cell Line, Tumor Cell migration cyclin D1 cyclin D3 Cyclin-dependent kinase 4 Disease Progression Female Gastric cancer Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Lymph nodes Male MAP kinase Middle Aged Neoplasm Invasiveness - genetics Phosphorylation Polymerase chain reaction Prognosis Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Reverse transcription RON Ron protein Signal transduction Signal Transduction - genetics siRNA stomach neoplasm Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumor cell lines Tumor cells tumor metastasis Tumors
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