Polycystic Kidney Disease Presenting With Hypertension and Hypokalemia
Hypokalemic hypertension is a common condition leading to the diagnosis of secondary hypertension. We report the case of a 60-year-old woman for whom the diagnosis of autosomal dominant polycystic kidney disease arose during the investigation of possible hyperaldosteronism. Activation of the renin s...
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| Veröffentlicht in: | American journal of kidney diseases 2012-02, Vol.59 (2), p.270-272, Article 270 |
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| container_title | American journal of kidney diseases |
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| creator | Chow, Kai Ming, MBChB, FRCP Ma, Ronald Ching-Wan, MB, BChir, MRCP Szeto, Cheuk Chun, MD, FRCP Li, Philip Kam-Tao, MD, FRCP |
| description | Hypokalemic hypertension is a common condition leading to the diagnosis of secondary hypertension. We report the case of a 60-year-old woman for whom the diagnosis of autosomal dominant polycystic kidney disease arose during the investigation of possible hyperaldosteronism. Activation of the renin system, as supported by recent studies, can explain the mechanism of hypokalemia and hypertension in this inherited cystic kidney disorder. Clinicians should be aware of this relatively uncommon clinical phenomenon of secondary hypertension in polycystic kidney disease. Increased understanding of the disorder's underlying mechanism should lay the foundation for better appreciation of potentially effective blood pressure treatments. The availability of a direct renin inhibitor may redirect research toward finding a remedy for this troublesome disease. |
| doi_str_mv | 10.1053/j.ajkd.2011.08.020 |
| format | Article |
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We report the case of a 60-year-old woman for whom the diagnosis of autosomal dominant polycystic kidney disease arose during the investigation of possible hyperaldosteronism. Activation of the renin system, as supported by recent studies, can explain the mechanism of hypokalemia and hypertension in this inherited cystic kidney disorder. Clinicians should be aware of this relatively uncommon clinical phenomenon of secondary hypertension in polycystic kidney disease. Increased understanding of the disorder's underlying mechanism should lay the foundation for better appreciation of potentially effective blood pressure treatments. The availability of a direct renin inhibitor may redirect research toward finding a remedy for this troublesome disease.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2011.08.020</identifier><identifier>PMID: 21962616</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amides - therapeutic use ; Arterial hypertension. Arterial hypotension ; Autosomal dominant polycystic kidney disease ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Female ; Fumarates - therapeutic use ; Humans ; hypertension ; Hypertension - diagnosis ; Hypertension - drug therapy ; Hypertension - etiology ; hypokalemia ; Hypokalemia - diagnosis ; Hypokalemia - drug therapy ; Hypokalemia - etiology ; Kidneys ; Malformations of the urinary system ; Medical sciences ; Middle Aged ; Nephrology ; Nephrology. Urinary tract diseases ; Polycystic Kidney, Autosomal Dominant - complications ; Polycystic Kidney, Autosomal Dominant - genetics ; Potassium Chloride - therapeutic use ; renin ; Renin - antagonists & inhibitors ; renin-angiotensin-aldosterone system (RAAS) ; Treatment Outcome</subject><ispartof>American journal of kidney diseases, 2012-02, Vol.59 (2), p.270-272, Article 270</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2012 National Kidney Foundation, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-def28e652d6d98289400753925fda8ef84d105f67958ab9b42f252745df7cb153</citedby><cites>FETCH-LOGICAL-c440t-def28e652d6d98289400753925fda8ef84d105f67958ab9b42f252745df7cb153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638611012753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25767612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21962616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chow, Kai Ming, MBChB, FRCP</creatorcontrib><creatorcontrib>Ma, Ronald Ching-Wan, MB, BChir, MRCP</creatorcontrib><creatorcontrib>Szeto, Cheuk Chun, MD, FRCP</creatorcontrib><creatorcontrib>Li, Philip Kam-Tao, MD, FRCP</creatorcontrib><title>Polycystic Kidney Disease Presenting With Hypertension and Hypokalemia</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Hypokalemic hypertension is a common condition leading to the diagnosis of secondary hypertension. We report the case of a 60-year-old woman for whom the diagnosis of autosomal dominant polycystic kidney disease arose during the investigation of possible hyperaldosteronism. Activation of the renin system, as supported by recent studies, can explain the mechanism of hypokalemia and hypertension in this inherited cystic kidney disorder. Clinicians should be aware of this relatively uncommon clinical phenomenon of secondary hypertension in polycystic kidney disease. Increased understanding of the disorder's underlying mechanism should lay the foundation for better appreciation of potentially effective blood pressure treatments. The availability of a direct renin inhibitor may redirect research toward finding a remedy for this troublesome disease.</description><subject>Amides - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Autosomal dominant polycystic kidney disease</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Female</subject><subject>Fumarates - therapeutic use</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - etiology</subject><subject>hypokalemia</subject><subject>Hypokalemia - diagnosis</subject><subject>Hypokalemia - drug therapy</subject><subject>Hypokalemia - etiology</subject><subject>Kidneys</subject><subject>Malformations of the urinary system</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polycystic Kidney, Autosomal Dominant - complications</subject><subject>Polycystic Kidney, Autosomal Dominant - genetics</subject><subject>Potassium Chloride - therapeutic use</subject><subject>renin</subject><subject>Renin - antagonists & inhibitors</subject><subject>renin-angiotensin-aldosterone system (RAAS)</subject><subject>Treatment Outcome</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFrFDEUx4NY7Fr9Ah5kLuJppklmkklABKnWlhYsqHgM2eRFMzub2SZZYb69GXZV6KGnQPj9X15-7yH0iuCGYNaeD40eNrahmJAGiwZT_AStCKNtzUUrnqIVpj2teSv4KXqe0oAxli3nz9ApJZJTTvgKXd5N42zmlL2pbrwNMFcffQKdoLqLkCBkH35WP3z-VV3NO4gZQvJTqHSwy8W00SNsvX6BTpweE7w8nmfo--WnbxdX9e2Xz9cXH25r03U41xYcFcAZtdxKQYXsMO5ZKylzVgtworPlZ473kgm9luuOOspo3zHrerMmrD1Dbw91d3G630PKauuTgXHUAaZ9UpJwRmTb4ULSA2nilFIEp3bRb3WcFcFq0acGtehTiz6FhSr6Suj1sfx-vQX7L_LXVwHeHAGdjB5d1MH49J9jPe85oYUTD143PutczOWo_fh4D-8OUSgef3uIKhkPwYD1EUxWdvKPx98_iJvRB1-a3cAMaZj2MZQJKaISVVh9XXZkWRFCMKFlFu0fVAO0pg</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Chow, Kai Ming, MBChB, FRCP</creator><creator>Ma, Ronald Ching-Wan, MB, BChir, MRCP</creator><creator>Szeto, Cheuk Chun, MD, FRCP</creator><creator>Li, Philip Kam-Tao, MD, FRCP</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Polycystic Kidney Disease Presenting With Hypertension and Hypokalemia</title><author>Chow, Kai Ming, MBChB, FRCP ; Ma, Ronald Ching-Wan, MB, BChir, MRCP ; Szeto, Cheuk Chun, MD, FRCP ; Li, Philip Kam-Tao, MD, FRCP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-def28e652d6d98289400753925fda8ef84d105f67958ab9b42f252745df7cb153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amides - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Autosomal dominant polycystic kidney disease</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Female</topic><topic>Fumarates - therapeutic use</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - etiology</topic><topic>hypokalemia</topic><topic>Hypokalemia - diagnosis</topic><topic>Hypokalemia - drug therapy</topic><topic>Hypokalemia - etiology</topic><topic>Kidneys</topic><topic>Malformations of the urinary system</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology. 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| subjects | Amides - therapeutic use Arterial hypertension. Arterial hypotension Autosomal dominant polycystic kidney disease Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Female Fumarates - therapeutic use Humans hypertension Hypertension - diagnosis Hypertension - drug therapy Hypertension - etiology hypokalemia Hypokalemia - diagnosis Hypokalemia - drug therapy Hypokalemia - etiology Kidneys Malformations of the urinary system Medical sciences Middle Aged Nephrology Nephrology. Urinary tract diseases Polycystic Kidney, Autosomal Dominant - complications Polycystic Kidney, Autosomal Dominant - genetics Potassium Chloride - therapeutic use renin Renin - antagonists & inhibitors renin-angiotensin-aldosterone system (RAAS) Treatment Outcome |
| title | Polycystic Kidney Disease Presenting With Hypertension and Hypokalemia |
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