First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology
BACKGROUND The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of...
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| Veröffentlicht in: | Human reproduction (Oxford) 2012-02, Vol.27 (2), p.358-365 |
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| creator | Sánchez, O Llurba, E. Marsal, G. Domínguez, C. Aulesa, C. Sánchez-Durán, M.A. Goya, M.M. Alijotas-Reig, J. Carreras, E. Cabero, L. |
| description | BACKGROUND
The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of conception influences angiogenic status.
METHODS
This prospective study enrolled women with twin (n = 61) and singleton (n = 50) pregnancies. Dichorionic twin pregnancies were divided into two groups according to their mode of conception. Singleton pregnancies were used as the control group. Soluble fms-like tyrosine kinase (sFlt-1), free placental growth factor (PlGF) and soluble endoglin (sEng) concentrations were measured in the first trimester maternal serum.
RESULTS
In the first trimester, women with twin pregnancies had higher serum concentrations of the anti-angiogenic factor sFlt-1 than that with singleton pregnancies (3924 ± 250 versus 2426 ± 162 pg/ml, respectively; P < 0.001). Maternal serum PlGF concentrations were lower in singleton pregnancies than those in twin pregnancies (37 ± 3.7 versus 59 ± 5.6, respectively; P < 0.001). Serum concentrations of sFlt-1 were higher in twin pregnancies conceived by ART than those in spontaneous twin pregnancies (4313 ± 389 versus 3522 ± 300 pg/ml, respectively; P < 0.05). No differences between groups were observed for sEng.
CONCLUSIONS
In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases. |
| doi_str_mv | 10.1093/humrep/der394 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_916519235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/der394</oup_id><sourcerecordid>916519235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-4bda71939db5eca4bc5eb2a7c4bfe47289752fcc8954e1bb7459d135a05a923c3</originalsourceid><addsrcrecordid>eNqFkMtP3DAQh62qqCzQY6-VL1W5hPUzWXNDiEclJC5wjhxnsusqcYLHEeLUf71eZVuOXPyaT7_xfIR84-yCMyPXu3mIMK1biNKoT2TFVckKITX7TFZMlJuC85IfkxPE34zl46b8Qo6FyK9GmRX5c-sjJpqiHwATRIoQ54HasPXjFoJ3axuSL97vFJNNM1IfaHrNyxRhG2xwHvCSRuht8mPAnZ_oq087ahF9zm1zaYpjO7t9mSZwuzD24_btjBx1tkf4ethPyfPtzdP1ffHwePfr-uqhcHmsVKimtRU30rSNBmdV4zQ0wlZONR2oSmxMpUXn3MZoBbxpKqVNy6W2TFsjpJOn5OeSm3_xMudR68Gjg763AcYZa8NLzTOpM1kspIsjYoSunrIcG99qzuq98npRXi_KM__9kDw3A7T_6X-OM_DjAFh0tu_i3ha-c1orWQmZufOFG-fpg55_Ab68njU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>916519235</pqid></control><display><type>article</type><title>First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Sánchez, O ; Llurba, E. ; Marsal, G. ; Domínguez, C. ; Aulesa, C. ; Sánchez-Durán, M.A. ; Goya, M.M. ; Alijotas-Reig, J. ; Carreras, E. ; Cabero, L.</creator><creatorcontrib>Sánchez, O ; Llurba, E. ; Marsal, G. ; Domínguez, C. ; Aulesa, C. ; Sánchez-Durán, M.A. ; Goya, M.M. ; Alijotas-Reig, J. ; Carreras, E. ; Cabero, L.</creatorcontrib><description>BACKGROUND
The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of conception influences angiogenic status.
METHODS
This prospective study enrolled women with twin (n = 61) and singleton (n = 50) pregnancies. Dichorionic twin pregnancies were divided into two groups according to their mode of conception. Singleton pregnancies were used as the control group. Soluble fms-like tyrosine kinase (sFlt-1), free placental growth factor (PlGF) and soluble endoglin (sEng) concentrations were measured in the first trimester maternal serum.
RESULTS
In the first trimester, women with twin pregnancies had higher serum concentrations of the anti-angiogenic factor sFlt-1 than that with singleton pregnancies (3924 ± 250 versus 2426 ± 162 pg/ml, respectively; P < 0.001). Maternal serum PlGF concentrations were lower in singleton pregnancies than those in twin pregnancies (37 ± 3.7 versus 59 ± 5.6, respectively; P < 0.001). Serum concentrations of sFlt-1 were higher in twin pregnancies conceived by ART than those in spontaneous twin pregnancies (4313 ± 389 versus 3522 ± 300 pg/ml, respectively; P < 0.05). No differences between groups were observed for sEng.
CONCLUSIONS
In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/der394</identifier><identifier>PMID: 22116949</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Angiogenesis Inhibitors - blood ; Angiogenic Proteins - blood ; Antigens, CD - blood ; Antigens, CD - chemistry ; Biological and medical sciences ; Cohort Studies ; Endoglin ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Placenta Growth Factor ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - etiology ; Pregnancy ; Pregnancy Proteins - blood ; Pregnancy Proteins - chemistry ; Pregnancy Trimester, First ; Pregnancy, Twin - blood ; Prospective Studies ; Receptors, Cell Surface - blood ; Receptors, Cell Surface - chemistry ; Reproductive Techniques, Assisted - adverse effects ; Risk ; Solubility ; Spain - epidemiology ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Vascular Endothelial Growth Factor Receptor-1 - chemistry</subject><ispartof>Human reproduction (Oxford), 2012-02, Vol.27 (2), p.358-365</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-4bda71939db5eca4bc5eb2a7c4bfe47289752fcc8954e1bb7459d135a05a923c3</citedby><cites>FETCH-LOGICAL-c394t-4bda71939db5eca4bc5eb2a7c4bfe47289752fcc8954e1bb7459d135a05a923c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25543723$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22116949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez, O</creatorcontrib><creatorcontrib>Llurba, E.</creatorcontrib><creatorcontrib>Marsal, G.</creatorcontrib><creatorcontrib>Domínguez, C.</creatorcontrib><creatorcontrib>Aulesa, C.</creatorcontrib><creatorcontrib>Sánchez-Durán, M.A.</creatorcontrib><creatorcontrib>Goya, M.M.</creatorcontrib><creatorcontrib>Alijotas-Reig, J.</creatorcontrib><creatorcontrib>Carreras, E.</creatorcontrib><creatorcontrib>Cabero, L.</creatorcontrib><title>First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND
The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of conception influences angiogenic status.
METHODS
This prospective study enrolled women with twin (n = 61) and singleton (n = 50) pregnancies. Dichorionic twin pregnancies were divided into two groups according to their mode of conception. Singleton pregnancies were used as the control group. Soluble fms-like tyrosine kinase (sFlt-1), free placental growth factor (PlGF) and soluble endoglin (sEng) concentrations were measured in the first trimester maternal serum.
RESULTS
In the first trimester, women with twin pregnancies had higher serum concentrations of the anti-angiogenic factor sFlt-1 than that with singleton pregnancies (3924 ± 250 versus 2426 ± 162 pg/ml, respectively; P < 0.001). Maternal serum PlGF concentrations were lower in singleton pregnancies than those in twin pregnancies (37 ± 3.7 versus 59 ± 5.6, respectively; P < 0.001). Serum concentrations of sFlt-1 were higher in twin pregnancies conceived by ART than those in spontaneous twin pregnancies (4313 ± 389 versus 3522 ± 300 pg/ml, respectively; P < 0.05). No differences between groups were observed for sEng.
CONCLUSIONS
In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases.</description><subject>Adult</subject><subject>Angiogenesis Inhibitors - blood</subject><subject>Angiogenic Proteins - blood</subject><subject>Antigens, CD - blood</subject><subject>Antigens, CD - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Endoglin</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Placenta Growth Factor</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - etiology</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Proteins - chemistry</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy, Twin - blood</subject><subject>Prospective Studies</subject><subject>Receptors, Cell Surface - blood</subject><subject>Receptors, Cell Surface - chemistry</subject><subject>Reproductive Techniques, Assisted - adverse effects</subject><subject>Risk</subject><subject>Solubility</subject><subject>Spain - epidemiology</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - chemistry</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtP3DAQh62qqCzQY6-VL1W5hPUzWXNDiEclJC5wjhxnsusqcYLHEeLUf71eZVuOXPyaT7_xfIR84-yCMyPXu3mIMK1biNKoT2TFVckKITX7TFZMlJuC85IfkxPE34zl46b8Qo6FyK9GmRX5c-sjJpqiHwATRIoQ54HasPXjFoJ3axuSL97vFJNNM1IfaHrNyxRhG2xwHvCSRuht8mPAnZ_oq087ahF9zm1zaYpjO7t9mSZwuzD24_btjBx1tkf4ethPyfPtzdP1ffHwePfr-uqhcHmsVKimtRU30rSNBmdV4zQ0wlZONR2oSmxMpUXn3MZoBbxpKqVNy6W2TFsjpJOn5OeSm3_xMudR68Gjg763AcYZa8NLzTOpM1kspIsjYoSunrIcG99qzuq98npRXi_KM__9kDw3A7T_6X-OM_DjAFh0tu_i3ha-c1orWQmZufOFG-fpg55_Ab68njU</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Sánchez, O</creator><creator>Llurba, E.</creator><creator>Marsal, G.</creator><creator>Domínguez, C.</creator><creator>Aulesa, C.</creator><creator>Sánchez-Durán, M.A.</creator><creator>Goya, M.M.</creator><creator>Alijotas-Reig, J.</creator><creator>Carreras, E.</creator><creator>Cabero, L.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology</title><author>Sánchez, O ; Llurba, E. ; Marsal, G. ; Domínguez, C. ; Aulesa, C. ; Sánchez-Durán, M.A. ; Goya, M.M. ; Alijotas-Reig, J. ; Carreras, E. ; Cabero, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-4bda71939db5eca4bc5eb2a7c4bfe47289752fcc8954e1bb7459d135a05a923c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Angiogenesis Inhibitors - blood</topic><topic>Angiogenic Proteins - blood</topic><topic>Antigens, CD - blood</topic><topic>Antigens, CD - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Endoglin</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Placenta Growth Factor</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Pre-Eclampsia - etiology</topic><topic>Pregnancy</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Proteins - chemistry</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy, Twin - blood</topic><topic>Prospective Studies</topic><topic>Receptors, Cell Surface - blood</topic><topic>Receptors, Cell Surface - chemistry</topic><topic>Reproductive Techniques, Assisted - adverse effects</topic><topic>Risk</topic><topic>Solubility</topic><topic>Spain - epidemiology</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez, O</creatorcontrib><creatorcontrib>Llurba, E.</creatorcontrib><creatorcontrib>Marsal, G.</creatorcontrib><creatorcontrib>Domínguez, C.</creatorcontrib><creatorcontrib>Aulesa, C.</creatorcontrib><creatorcontrib>Sánchez-Durán, M.A.</creatorcontrib><creatorcontrib>Goya, M.M.</creatorcontrib><creatorcontrib>Alijotas-Reig, J.</creatorcontrib><creatorcontrib>Carreras, E.</creatorcontrib><creatorcontrib>Cabero, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez, O</au><au>Llurba, E.</au><au>Marsal, G.</au><au>Domínguez, C.</au><au>Aulesa, C.</au><au>Sánchez-Durán, M.A.</au><au>Goya, M.M.</au><au>Alijotas-Reig, J.</au><au>Carreras, E.</au><au>Cabero, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>27</volume><issue>2</issue><spage>358</spage><epage>365</epage><pages>358-365</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND
The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of conception influences angiogenic status.
METHODS
This prospective study enrolled women with twin (n = 61) and singleton (n = 50) pregnancies. Dichorionic twin pregnancies were divided into two groups according to their mode of conception. Singleton pregnancies were used as the control group. Soluble fms-like tyrosine kinase (sFlt-1), free placental growth factor (PlGF) and soluble endoglin (sEng) concentrations were measured in the first trimester maternal serum.
RESULTS
In the first trimester, women with twin pregnancies had higher serum concentrations of the anti-angiogenic factor sFlt-1 than that with singleton pregnancies (3924 ± 250 versus 2426 ± 162 pg/ml, respectively; P < 0.001). Maternal serum PlGF concentrations were lower in singleton pregnancies than those in twin pregnancies (37 ± 3.7 versus 59 ± 5.6, respectively; P < 0.001). Serum concentrations of sFlt-1 were higher in twin pregnancies conceived by ART than those in spontaneous twin pregnancies (4313 ± 389 versus 3522 ± 300 pg/ml, respectively; P < 0.05). No differences between groups were observed for sEng.
CONCLUSIONS
In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22116949</pmid><doi>10.1093/humrep/der394</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Angiogenesis Inhibitors - blood Angiogenic Proteins - blood Antigens, CD - blood Antigens, CD - chemistry Biological and medical sciences Cohort Studies Endoglin Female Gynecology. Andrology. Obstetrics Humans Medical sciences Placenta Growth Factor Pre-Eclampsia - epidemiology Pre-Eclampsia - etiology Pregnancy Pregnancy Proteins - blood Pregnancy Proteins - chemistry Pregnancy Trimester, First Pregnancy, Twin - blood Prospective Studies Receptors, Cell Surface - blood Receptors, Cell Surface - chemistry Reproductive Techniques, Assisted - adverse effects Risk Solubility Spain - epidemiology Vascular Endothelial Growth Factor Receptor-1 - blood Vascular Endothelial Growth Factor Receptor-1 - chemistry |
| title | First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology |
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