Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma
The clinical usefulness of BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification. BCL6 mRNA expression was measured by...
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| Veröffentlicht in: | The veterinary journal (1997) 2012, Vol.191 (1), p.108-114 |
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| container_title | The veterinary journal (1997) |
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| creator | Sato, Masahiko Kanemoto, Hideyuki Kagawa, Yumiko Kobayashi, Tetsuya Goto-Koshino, Yuko Mochizuki, Hiroyuki Takahashi, Masashi Fujino, Yasuhito Ohno, Koichi Tsujimoto, Hajime |
| description | The clinical usefulness of
BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification.
BCL6 mRNA expression was measured by real-time PCR and its relationship with prognosis was analyzed. Progression-free and overall survival was not significantly different between the high
BCL6 expression group (higher than the median) and the low
BCL6 expression group (lower than the median) (
P
=
0.99 and
P
=
0.61, respectively). No correlation between
BCL6 and prognosis was observed in this study, which is inconsistent with findings reported for human diffuse large B-cell lymphoma.
BCL6 protein expression was not detected in the 11 dogs evaluated by immunohistochemistry. Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative. The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6. |
| doi_str_mv | 10.1016/j.tvjl.2010.12.006 |
| format | Article |
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BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification.
BCL6 mRNA expression was measured by real-time PCR and its relationship with prognosis was analyzed. Progression-free and overall survival was not significantly different between the high
BCL6 expression group (higher than the median) and the low
BCL6 expression group (lower than the median) (
P
=
0.99 and
P
=
0.61, respectively). No correlation between
BCL6 and prognosis was observed in this study, which is inconsistent with findings reported for human diffuse large B-cell lymphoma.
BCL6 protein expression was not detected in the 11 dogs evaluated by immunohistochemistry. Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative. The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2010.12.006</identifier><identifier>PMID: 21277811</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; B-lymphocytes ; BCL6 ; Diffuse large B-cell lymphoma ; Disease-Free Survival ; Dog ; Dog Diseases - genetics ; Dog Diseases - mortality ; Dog Diseases - pathology ; Dogs ; Female ; gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; immunohistochemistry ; Lymphoma ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - mortality ; Lymphoma, B-Cell - veterinary ; Male ; messenger RNA ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - veterinary ; Neoplasm Staging ; Oncology ; Prognosis ; protein synthesis ; Proto-Oncogene Proteins c-bcl-6 - genetics ; quantitative polymerase chain reaction ; RNA, Messenger - analysis</subject><ispartof>The veterinary journal (1997), 2012, Vol.191 (1), p.108-114</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-e67d2ef5c5fd32e74477371092d049a03eb6b41685a17c533c3d54fe141a4c5f3</citedby><cites>FETCH-LOGICAL-c445t-e67d2ef5c5fd32e74477371092d049a03eb6b41685a17c533c3d54fe141a4c5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2010.12.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21277811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Masahiko</creatorcontrib><creatorcontrib>Kanemoto, Hideyuki</creatorcontrib><creatorcontrib>Kagawa, Yumiko</creatorcontrib><creatorcontrib>Kobayashi, Tetsuya</creatorcontrib><creatorcontrib>Goto-Koshino, Yuko</creatorcontrib><creatorcontrib>Mochizuki, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Masashi</creatorcontrib><creatorcontrib>Fujino, Yasuhito</creatorcontrib><creatorcontrib>Ohno, Koichi</creatorcontrib><creatorcontrib>Tsujimoto, Hajime</creatorcontrib><title>Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>The clinical usefulness of
BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification.
BCL6 mRNA expression was measured by real-time PCR and its relationship with prognosis was analyzed. Progression-free and overall survival was not significantly different between the high
BCL6 expression group (higher than the median) and the low
BCL6 expression group (lower than the median) (
P
=
0.99 and
P
=
0.61, respectively). No correlation between
BCL6 and prognosis was observed in this study, which is inconsistent with findings reported for human diffuse large B-cell lymphoma.
BCL6 protein expression was not detected in the 11 dogs evaluated by immunohistochemistry. Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative. The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6.</description><subject>Animals</subject><subject>B-lymphocytes</subject><subject>BCL6</subject><subject>Diffuse large B-cell lymphoma</subject><subject>Disease-Free Survival</subject><subject>Dog</subject><subject>Dog Diseases - genetics</subject><subject>Dog Diseases - mortality</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - mortality</subject><subject>Lymphoma, B-Cell - veterinary</subject><subject>Male</subject><subject>messenger RNA</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - veterinary</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>protein synthesis</subject><subject>Proto-Oncogene Proteins c-bcl-6 - genetics</subject><subject>quantitative polymerase chain reaction</subject><subject>RNA, Messenger - analysis</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtP4zAURi00iPcfYAHesUrxM26k2UwrXlIlFsDacp3r1FUSFzut4N_jqDBLFpat6_NdXR8jdEnJhBJa3q4nw27dThgZC2xCSHmATqjkrGCVon_ymVSkIIzzY3Sa0poQUgnBjtAxo0ypKaUnyN3tTLs1gw89Dg4PK8CbGJo-pMFbnHzTe-et6S2M17P5osQN9IDhYxMhpTHme5wBn4sr36yKJpoa8Kyw0La4_ew2q9CZc3ToTJvg4ns_Q2_3d6_zx2Lx_PA0_7corBByKKBUNQMnrXQ1Z6CEUIqr_AxWE1EZwmFZLgUtp9JQZSXnltdSOKCCGpFD_Azd7PvmR7xvIQ2682mcxPQQtklXtKSSTEWVSbYnbQwpRXB6E31n4qemRI969VqPevWoV1Oms94cuvpuv112UP-P_PjMwPUecCZo00Sf9NtL7iBJXix_Syb-7gnIGnYeok7WQ_Zb-wh20HXwv03wBRyHlKA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Sato, Masahiko</creator><creator>Kanemoto, Hideyuki</creator><creator>Kagawa, Yumiko</creator><creator>Kobayashi, Tetsuya</creator><creator>Goto-Koshino, Yuko</creator><creator>Mochizuki, Hiroyuki</creator><creator>Takahashi, Masashi</creator><creator>Fujino, Yasuhito</creator><creator>Ohno, Koichi</creator><creator>Tsujimoto, Hajime</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma</title><author>Sato, Masahiko ; Kanemoto, Hideyuki ; Kagawa, Yumiko ; Kobayashi, Tetsuya ; Goto-Koshino, Yuko ; Mochizuki, Hiroyuki ; Takahashi, Masashi ; Fujino, Yasuhito ; Ohno, Koichi ; Tsujimoto, Hajime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-e67d2ef5c5fd32e74477371092d049a03eb6b41685a17c533c3d54fe141a4c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>B-lymphocytes</topic><topic>BCL6</topic><topic>Diffuse large B-cell lymphoma</topic><topic>Disease-Free Survival</topic><topic>Dog</topic><topic>Dog Diseases - genetics</topic><topic>Dog Diseases - mortality</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, B-Cell - mortality</topic><topic>Lymphoma, B-Cell - veterinary</topic><topic>Male</topic><topic>messenger RNA</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - veterinary</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>protein synthesis</topic><topic>Proto-Oncogene Proteins c-bcl-6 - genetics</topic><topic>quantitative polymerase chain reaction</topic><topic>RNA, Messenger - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Masahiko</creatorcontrib><creatorcontrib>Kanemoto, Hideyuki</creatorcontrib><creatorcontrib>Kagawa, Yumiko</creatorcontrib><creatorcontrib>Kobayashi, Tetsuya</creatorcontrib><creatorcontrib>Goto-Koshino, Yuko</creatorcontrib><creatorcontrib>Mochizuki, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Masashi</creatorcontrib><creatorcontrib>Fujino, Yasuhito</creatorcontrib><creatorcontrib>Ohno, Koichi</creatorcontrib><creatorcontrib>Tsujimoto, Hajime</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Masahiko</au><au>Kanemoto, Hideyuki</au><au>Kagawa, Yumiko</au><au>Kobayashi, Tetsuya</au><au>Goto-Koshino, Yuko</au><au>Mochizuki, Hiroyuki</au><au>Takahashi, Masashi</au><au>Fujino, Yasuhito</au><au>Ohno, Koichi</au><au>Tsujimoto, Hajime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2012</date><risdate>2012</risdate><volume>191</volume><issue>1</issue><spage>108</spage><epage>114</epage><pages>108-114</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>The clinical usefulness of
BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification.
BCL6 mRNA expression was measured by real-time PCR and its relationship with prognosis was analyzed. Progression-free and overall survival was not significantly different between the high
BCL6 expression group (higher than the median) and the low
BCL6 expression group (lower than the median) (
P
=
0.99 and
P
=
0.61, respectively). No correlation between
BCL6 and prognosis was observed in this study, which is inconsistent with findings reported for human diffuse large B-cell lymphoma.
BCL6 protein expression was not detected in the 11 dogs evaluated by immunohistochemistry. Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative. The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21277811</pmid><doi>10.1016/j.tvjl.2010.12.006</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1090-0233 |
| ispartof | The veterinary journal (1997), 2012, Vol.191 (1), p.108-114 |
| issn | 1090-0233 1532-2971 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_916150849 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals B-lymphocytes BCL6 Diffuse large B-cell lymphoma Disease-Free Survival Dog Dog Diseases - genetics Dog Diseases - mortality Dog Diseases - pathology Dogs Female gene expression Gene Expression Regulation, Neoplastic Humans immunohistochemistry Lymphoma Lymphoma, B-Cell - genetics Lymphoma, B-Cell - mortality Lymphoma, B-Cell - veterinary Male messenger RNA Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - veterinary Neoplasm Staging Oncology Prognosis protein synthesis Proto-Oncogene Proteins c-bcl-6 - genetics quantitative polymerase chain reaction RNA, Messenger - analysis |
| title | Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma |
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