Fibroblast adhesion on unidirectional polymeric nanofilms
Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a la...
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| Veröffentlicht in: | Biointerphases 2011-12, Vol.6 (4), p.158-163 |
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| creator | Christophis, Christof Sekeroglu, Koray Demirel, Gokhan Thome, Isabel Grunze, Michael Demirel, Melik C Rosenhahn, Axel |
| description | Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal. |
| doi_str_mv | 10.1116/1.3646093 |
| format | Article |
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In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal.</description><subject>Animals</subject><subject>Cell Adhesion - drug effects</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - ultrastructure</subject><subject>Microfluidics</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Polymers - metabolism</subject><subject>Polymers - pharmacology</subject><subject>Pseudopodia - drug effects</subject><subject>Rats</subject><subject>Rheology - drug effects</subject><subject>Xylenes - pharmacology</subject><issn>1934-8630</issn><issn>1559-4106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KxDAUhYMozji68AWkO3HRMelN0mQpg6PCgBtdh7RNMJI2NWkX8_a2TBUu9wc-zrkchG4J3hJC-CPZAqccSzhDa8KYzCnB_HzaJdBccMArdJXSN8aUMQ6XaFUUBUiBxRrJvatiqLxOQ6abL5Nc6LKpxs41Lpp6mG7tsz74Y2uiq7NOd8E636ZrdGG1T-ZmmRv0uX_-2L3mh_eXt93TIa-ByCFvcKFZQakEIoBS0czGrCpFVeGSYzp3MDXosrHMysJQRrXFRlM2_Ws5bND9SbeP4Wc0aVCtS7XxXncmjElJwgkVQszkw4msY0gpGqv66Fodj4pgNQeliFqCmti7RXWsWtP8k3_JwC8EC2FL</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Christophis, Christof</creator><creator>Sekeroglu, Koray</creator><creator>Demirel, Gokhan</creator><creator>Thome, Isabel</creator><creator>Grunze, Michael</creator><creator>Demirel, Melik C</creator><creator>Rosenhahn, Axel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Fibroblast adhesion on unidirectional polymeric nanofilms</title><author>Christophis, Christof ; Sekeroglu, Koray ; Demirel, Gokhan ; Thome, Isabel ; Grunze, Michael ; Demirel, Melik C ; Rosenhahn, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-d02a524493183448d39805b78bb07604b0763ec3a7df5f92e454af0ea45004f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cell Adhesion - drug effects</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroblasts - ultrastructure</topic><topic>Microfluidics</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - ultrastructure</topic><topic>Polymers - metabolism</topic><topic>Polymers - pharmacology</topic><topic>Pseudopodia - drug effects</topic><topic>Rats</topic><topic>Rheology - drug effects</topic><topic>Xylenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christophis, Christof</creatorcontrib><creatorcontrib>Sekeroglu, Koray</creatorcontrib><creatorcontrib>Demirel, Gokhan</creatorcontrib><creatorcontrib>Thome, Isabel</creatorcontrib><creatorcontrib>Grunze, Michael</creatorcontrib><creatorcontrib>Demirel, Melik C</creatorcontrib><creatorcontrib>Rosenhahn, Axel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biointerphases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christophis, Christof</au><au>Sekeroglu, Koray</au><au>Demirel, Gokhan</au><au>Thome, Isabel</au><au>Grunze, Michael</au><au>Demirel, Melik C</au><au>Rosenhahn, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibroblast adhesion on unidirectional polymeric nanofilms</atitle><jtitle>Biointerphases</jtitle><addtitle>Biointerphases</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>6</volume><issue>4</issue><spage>158</spage><epage>163</epage><pages>158-163</pages><issn>1934-8630</issn><eissn>1559-4106</eissn><abstract>Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. 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| ispartof | Biointerphases, 2011-12, Vol.6 (4), p.158-163 |
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| source | MEDLINE; AIP Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Cell Adhesion - drug effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - ultrastructure Microfluidics Nanostructures - chemistry Nanostructures - ultrastructure Polymers - metabolism Polymers - pharmacology Pseudopodia - drug effects Rats Rheology - drug effects Xylenes - pharmacology |
| title | Fibroblast adhesion on unidirectional polymeric nanofilms |
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