Automatic identification of gray and white matter components in polarized light imaging

Polarized light imaging (PLI) enables the visualization of fiber tracts with high spatial resolution in microtome sections of postmortem brains. Vectors of the fiber orientation defined by inclination and direction angles can directly be derived from the optical signals employed by PLI analysis. The...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2012-01, Vol.59 (2), p.1338-1347
Hauptverfasser: Dammers, Jürgen, Breuer, Lukas, Axer, Markus, Kleiner, Melanie, Eiben, Björn, Gräßel, David, Dickscheid, Timo, Zilles, Karl, Amunts, Katrin, Shah, N. Joni, Pietrzyk, Uwe
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container_issue 2
container_start_page 1338
container_title NeuroImage (Orlando, Fla.)
container_volume 59
creator Dammers, Jürgen
Breuer, Lukas
Axer, Markus
Kleiner, Melanie
Eiben, Björn
Gräßel, David
Dickscheid, Timo
Zilles, Karl
Amunts, Katrin
Shah, N. Joni
Pietrzyk, Uwe
description Polarized light imaging (PLI) enables the visualization of fiber tracts with high spatial resolution in microtome sections of postmortem brains. Vectors of the fiber orientation defined by inclination and direction angles can directly be derived from the optical signals employed by PLI analysis. The polarization state of light propagating through a rotating polarimeter is varied in such a way that the detected signal of each spatial unit describes a sinusoidal signal. Noise, light scatter and filter inhomogeneities, however, interfere with the original sinusoidal PLI signals, which in turn have direct impact on the accuracy of subsequent fiber tracking. Recently we showed that the primary sinusoidal signals can effectively be restored after noise and artifact rejection utilizing independent component analysis (ICA). In particular, regions with weak intensities are greatly enhanced after ICA based artifact rejection and signal restoration. Here, we propose a user independent way of identifying the components of interest after decomposition; i.e., components that are related to gray and white matter. Depending on the size of the postmortem brain and the section thickness, the number of independent component maps can easily be in the range of a few ten thousand components for one brain. Therefore, we developed an automatic and, more importantly, user independent way of extracting the signal of interest. The automatic identification of gray and white matter components is based on the evaluation of the statistical properties of the so-called feature vectors of each individual component map, which, in the ideal case, shows a sinusoidal waveform. Our method enables large-scale analysis (i.e., the analysis of thousands of whole brain sections) of nerve fiber orientations in the human brain using polarized light imaging. ► Novel approach to automatically identify gray and white matter components from PLI. ► User independent way of signal enhancement in a large set of PLI images. ► The method includes artifact and noise rejection utilizing ICA. ► Regions with weak intensities are greatly enhanced after ICA. ► Our test statistic is sensitive to both, missing components and changes in SNR.
doi_str_mv 10.1016/j.neuroimage.2011.08.030
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Joni</au><au>Pietrzyk, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automatic identification of gray and white matter components in polarized light imaging</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2012-01-16</date><risdate>2012</risdate><volume>59</volume><issue>2</issue><spage>1338</spage><epage>1347</epage><pages>1338-1347</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Polarized light imaging (PLI) enables the visualization of fiber tracts with high spatial resolution in microtome sections of postmortem brains. Vectors of the fiber orientation defined by inclination and direction angles can directly be derived from the optical signals employed by PLI analysis. The polarization state of light propagating through a rotating polarimeter is varied in such a way that the detected signal of each spatial unit describes a sinusoidal signal. 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subjects Algorithms
Artificial Intelligence
Brain
Brain - cytology
Cameras
Digitization
Fiber tracking
Human connectome
Humans
ICA
Identification
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Independent component analysis
Light
Lighting - methods
Microscopy, Polarization - methods
Nerve Fibers, Myelinated - ultrastructure
Neurons - cytology
Noise
Pattern Recognition, Automated - methods
PLI
Polarized light imaging
Reproducibility of Results
Sensitivity and Specificity
Software
title Automatic identification of gray and white matter components in polarized light imaging
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