Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents

An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (10), p.1580-1582
Hauptverfasser: Le Bailly, Bryden A F, Greenhalgh, Mark D, Thomas, Stephen P
Format: Artikel
Sprache:eng
Schlagworte:
Alkanes
Alkanes - chemical synthesis
Alkanes - chemistry
Bromides
Catalysis
Chlorides
Halides
Iodides
Iron - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Oxidation-Reduction
Stereoisomerism
Vinyl Chloride - chemistry
Vinyl Compounds - chemistry
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Beschreibung
Zusammenfassung:An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc14622j