Subclinical Atrial Fibrillation and the Risk of Stroke
A cohort of 2580 patients with pacemakers or defibrillators were monitored for 3 months to detect subclinical atrial tachyarrhythmias. Patients with subclinical atrial tachyarrhythmias had a significantly increased risk of subsequent ischemic stroke. Atrial fibrillation may be asymptomatic and conse...
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| Veröffentlicht in: | The New England journal of medicine 2012-01, Vol.366 (2), p.120-129 |
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| creator | Healey, Jeff S Connolly, Stuart J Gold, Michael R Israel, Carsten W Van Gelder, Isabelle C Capucci, Alessandro Lau, C.P Fain, Eric Yang, Sean Bailleul, Christophe Morillo, Carlos A Carlson, Mark Themeles, Ellison Kaufman, Elizabeth S Hohnloser, Stefan H |
| description | A cohort of 2580 patients with pacemakers or defibrillators were monitored for 3 months to detect subclinical atrial tachyarrhythmias. Patients with subclinical atrial tachyarrhythmias had a significantly increased risk of subsequent ischemic stroke.
Atrial fibrillation may be asymptomatic and consequently subclinical.
1
,
2
Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.
3
About 15% of strokes are attributable to documented atrial fibrillation, and 50 to 60% to documented cerebrovascular disease,
4
–
7
but in about 25% of patients who have ischemic strokes, no etiologic factor is identified.
4
,
8
,
9
Subclinical atrial fibrillation is often suspected to be the cause of stroke in these patients.
10
However, the prevalence and prognostic value of subclinical atrial fibrillation has been difficult to assess.
8
,
9
,
11
,
12
An . . . |
| doi_str_mv | 10.1056/NEJMoa1105575 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_916146755</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>916146755</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-e68298cd5d17ccbacf9bf100e8d81fc65f54019aeb09a98c630c449b9a44510e3</originalsourceid><addsrcrecordid>eNp10M9LwzAUB_AgipvTo1cpgniq5rVJmhxlbP5gKjg9lzRNMVvbzKQ9-N8b3XQo-A55OXx47_FF6BjwBWDKLh8md_dWQvjTjO6gIdA0jQnBbBcNMU54TDKRDtCB9wscCojYR4MkSVIWniFi875QtWmNknV01TkT2tQUztS17IxtI9mWUfeqoyfjl5Gtonnn7FIfor1K1l4fbfoIvUwnz-ObePZ4fTu-msWKZkkXa8YTwVVJS8iUKqSqRFEBxpqXHCrFaEUJBiF1gYUMkKVYESIKIQmhgHU6QufruStn33rtu7wxXulwXKtt73MBDAjLKA3y9I9c2N614bgvxDCnEFC8RspZ752u8pUzjXTvOeD8M878V5zBn2yG9kWjyx_9nV8AZxsgfUiwcrJVxm8dJTzhAFvXND5v9aL5Z-EHv3iGQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>916160851</pqid></control><display><type>article</type><title>Subclinical Atrial Fibrillation and the Risk of Stroke</title><source>MEDLINE</source><source>1990</source><source>EZB Electronic Journals Library</source><creator>Healey, Jeff S ; Connolly, Stuart J ; Gold, Michael R ; Israel, Carsten W ; Van Gelder, Isabelle C ; Capucci, Alessandro ; Lau, C.P ; Fain, Eric ; Yang, Sean ; Bailleul, Christophe ; Morillo, Carlos A ; Carlson, Mark ; Themeles, Ellison ; Kaufman, Elizabeth S ; Hohnloser, Stefan H</creator><creatorcontrib>Healey, Jeff S ; Connolly, Stuart J ; Gold, Michael R ; Israel, Carsten W ; Van Gelder, Isabelle C ; Capucci, Alessandro ; Lau, C.P ; Fain, Eric ; Yang, Sean ; Bailleul, Christophe ; Morillo, Carlos A ; Carlson, Mark ; Themeles, Ellison ; Kaufman, Elizabeth S ; Hohnloser, Stefan H ; ASSERT Investigators</creatorcontrib><description>A cohort of 2580 patients with pacemakers or defibrillators were monitored for 3 months to detect subclinical atrial tachyarrhythmias. Patients with subclinical atrial tachyarrhythmias had a significantly increased risk of subsequent ischemic stroke.
Atrial fibrillation may be asymptomatic and consequently subclinical.
1
,
2
Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.
3
About 15% of strokes are attributable to documented atrial fibrillation, and 50 to 60% to documented cerebrovascular disease,
4
–
7
but in about 25% of patients who have ischemic strokes, no etiologic factor is identified.
4
,
8
,
9
Subclinical atrial fibrillation is often suspected to be the cause of stroke in these patients.
10
However, the prevalence and prognostic value of subclinical atrial fibrillation has been difficult to assess.
8
,
9
,
11
,
12
An . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1105575</identifier><identifier>PMID: 22236222</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Aged ; Aged, 80 and over ; Atrial Fibrillation - complications ; Atrial Fibrillation - therapy ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial - methods ; Cardiology. Vascular system ; Defibrillators, Implantable ; Electrocardiography ; Embolism ; Embolism - etiology ; Female ; Fibrillation ; General aspects ; Heart ; Humans ; Hypertension - complications ; Ischemia ; Male ; Medical research ; Medical sciences ; Neurology ; Pacemaker, Artificial ; Pacemakers ; Prospective Studies ; Risk ; Stroke ; Stroke - etiology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>The New England journal of medicine, 2012-01, Vol.366 (2), p.120-129</ispartof><rights>Copyright © 2012 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-e68298cd5d17ccbacf9bf100e8d81fc65f54019aeb09a98c630c449b9a44510e3</citedby><cites>FETCH-LOGICAL-c572t-e68298cd5d17ccbacf9bf100e8d81fc65f54019aeb09a98c630c449b9a44510e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1105575$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1105575$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25482811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22236222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Healey, Jeff S</creatorcontrib><creatorcontrib>Connolly, Stuart J</creatorcontrib><creatorcontrib>Gold, Michael R</creatorcontrib><creatorcontrib>Israel, Carsten W</creatorcontrib><creatorcontrib>Van Gelder, Isabelle C</creatorcontrib><creatorcontrib>Capucci, Alessandro</creatorcontrib><creatorcontrib>Lau, C.P</creatorcontrib><creatorcontrib>Fain, Eric</creatorcontrib><creatorcontrib>Yang, Sean</creatorcontrib><creatorcontrib>Bailleul, Christophe</creatorcontrib><creatorcontrib>Morillo, Carlos A</creatorcontrib><creatorcontrib>Carlson, Mark</creatorcontrib><creatorcontrib>Themeles, Ellison</creatorcontrib><creatorcontrib>Kaufman, Elizabeth S</creatorcontrib><creatorcontrib>Hohnloser, Stefan H</creatorcontrib><creatorcontrib>ASSERT Investigators</creatorcontrib><title>Subclinical Atrial Fibrillation and the Risk of Stroke</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>A cohort of 2580 patients with pacemakers or defibrillators were monitored for 3 months to detect subclinical atrial tachyarrhythmias. Patients with subclinical atrial tachyarrhythmias had a significantly increased risk of subsequent ischemic stroke.
Atrial fibrillation may be asymptomatic and consequently subclinical.
1
,
2
Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.
3
About 15% of strokes are attributable to documented atrial fibrillation, and 50 to 60% to documented cerebrovascular disease,
4
–
7
but in about 25% of patients who have ischemic strokes, no etiologic factor is identified.
4
,
8
,
9
Subclinical atrial fibrillation is often suspected to be the cause of stroke in these patients.
10
However, the prevalence and prognostic value of subclinical atrial fibrillation has been difficult to assess.
8
,
9
,
11
,
12
An . . .</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>Cardiology. Vascular system</subject><subject>Defibrillators, Implantable</subject><subject>Electrocardiography</subject><subject>Embolism</subject><subject>Embolism - etiology</subject><subject>Female</subject><subject>Fibrillation</subject><subject>General aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Pacemaker, Artificial</subject><subject>Pacemakers</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10M9LwzAUB_AgipvTo1cpgniq5rVJmhxlbP5gKjg9lzRNMVvbzKQ9-N8b3XQo-A55OXx47_FF6BjwBWDKLh8md_dWQvjTjO6gIdA0jQnBbBcNMU54TDKRDtCB9wscCojYR4MkSVIWniFi875QtWmNknV01TkT2tQUztS17IxtI9mWUfeqoyfjl5Gtonnn7FIfor1K1l4fbfoIvUwnz-ObePZ4fTu-msWKZkkXa8YTwVVJS8iUKqSqRFEBxpqXHCrFaEUJBiF1gYUMkKVYESIKIQmhgHU6QufruStn33rtu7wxXulwXKtt73MBDAjLKA3y9I9c2N614bgvxDCnEFC8RspZ752u8pUzjXTvOeD8M878V5zBn2yG9kWjyx_9nV8AZxsgfUiwcrJVxm8dJTzhAFvXND5v9aL5Z-EHv3iGQQ</recordid><startdate>20120112</startdate><enddate>20120112</enddate><creator>Healey, Jeff S</creator><creator>Connolly, Stuart J</creator><creator>Gold, Michael R</creator><creator>Israel, Carsten W</creator><creator>Van Gelder, Isabelle C</creator><creator>Capucci, Alessandro</creator><creator>Lau, C.P</creator><creator>Fain, Eric</creator><creator>Yang, Sean</creator><creator>Bailleul, Christophe</creator><creator>Morillo, Carlos A</creator><creator>Carlson, Mark</creator><creator>Themeles, Ellison</creator><creator>Kaufman, Elizabeth S</creator><creator>Hohnloser, Stefan H</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120112</creationdate><title>Subclinical Atrial Fibrillation and the Risk of Stroke</title><author>Healey, Jeff S ; Connolly, Stuart J ; Gold, Michael R ; Israel, Carsten W ; Van Gelder, Isabelle C ; Capucci, Alessandro ; Lau, C.P ; Fain, Eric ; Yang, Sean ; Bailleul, Christophe ; Morillo, Carlos A ; Carlson, Mark ; Themeles, Ellison ; Kaufman, Elizabeth S ; Hohnloser, Stefan H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-e68298cd5d17ccbacf9bf100e8d81fc65f54019aeb09a98c630c449b9a44510e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial - methods</topic><topic>Cardiology. 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Healey, Jeff S</au><au>Connolly, Stuart J</au><au>Gold, Michael R</au><au>Israel, Carsten W</au><au>Van Gelder, Isabelle C</au><au>Capucci, Alessandro</au><au>Lau, C.P</au><au>Fain, Eric</au><au>Yang, Sean</au><au>Bailleul, Christophe</au><au>Morillo, Carlos A</au><au>Carlson, Mark</au><au>Themeles, Ellison</au><au>Kaufman, Elizabeth S</au><au>Hohnloser, Stefan H</au><aucorp>ASSERT Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subclinical Atrial Fibrillation and the Risk of Stroke</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2012-01-12</date><risdate>2012</risdate><volume>366</volume><issue>2</issue><spage>120</spage><epage>129</epage><pages>120-129</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>A cohort of 2580 patients with pacemakers or defibrillators were monitored for 3 months to detect subclinical atrial tachyarrhythmias. Patients with subclinical atrial tachyarrhythmias had a significantly increased risk of subsequent ischemic stroke.
Atrial fibrillation may be asymptomatic and consequently subclinical.
1
,
2
Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.
3
About 15% of strokes are attributable to documented atrial fibrillation, and 50 to 60% to documented cerebrovascular disease,
4
–
7
but in about 25% of patients who have ischemic strokes, no etiologic factor is identified.
4
,
8
,
9
Subclinical atrial fibrillation is often suspected to be the cause of stroke in these patients.
10
However, the prevalence and prognostic value of subclinical atrial fibrillation has been difficult to assess.
8
,
9
,
11
,
12
An . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>22236222</pmid><doi>10.1056/NEJMoa1105575</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The New England journal of medicine, 2012-01, Vol.366 (2), p.120-129 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; 1990; EZB Electronic Journals Library |
| subjects | Aged Aged, 80 and over Atrial Fibrillation - complications Atrial Fibrillation - therapy Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiac Pacing, Artificial - methods Cardiology. Vascular system Defibrillators, Implantable Electrocardiography Embolism Embolism - etiology Female Fibrillation General aspects Heart Humans Hypertension - complications Ischemia Male Medical research Medical sciences Neurology Pacemaker, Artificial Pacemakers Prospective Studies Risk Stroke Stroke - etiology Vascular diseases and vascular malformations of the nervous system |
| title | Subclinical Atrial Fibrillation and the Risk of Stroke |
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