The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats

Boldine, a major aporphine alkaloid found in Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimental role in the pathogenesis of endothelial dysfunction in hypertension. In the present study, we investigated the effects of boldine on endothelial dysfunction in hypertension...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2012-01, Vol.237 (1), p.93-98
Hauptverfasser:	Lau, Yeh-Siang, Machha, Ajay, Achike, Francis I, Murugan, Dharmani, Mustafa, Mohd Rais
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Antioxidants - pharmacology Aporphines - administration & dosage Aporphines - pharmacology Blood Pressure - drug effects Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Hypertension - drug therapy Hypertension - physiopathology Male NADPH Oxidases - biosynthesis Nitroprusside - pharmacology Oxidative Stress - drug effects Peroxynitrous Acid - metabolism Random Allocation Rats Rats, Wistar Superoxides - metabolism Vasodilation - drug effects
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