Intensity of In Vitro Incorporation of 3H-Melatonin in the Thyroid Gland of Rabbits with Pineal Gland Hypofunction
The structure and hormonal activity of the thyroid gland and its capacity to bind 3 H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals e...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2011-04, Vol.150 (6), p.753-755 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Bondarenko, L. A. Sotnik, N. N. Chagovets, E. M. Sergienko, L. Yu Cherevko, A. N. |
| description | The structure and hormonal activity of the thyroid gland and its capacity to bind
3
H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called “latent hypothyroidism” and more intense binding of
3
H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency. |
| doi_str_mv | 10.1007/s10517-011-1241-z |
| format | Article |
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3
H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called “latent hypothyroidism” and more intense binding of
3
H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-011-1241-z</identifier><identifier>PMID: 22235435</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Hypothyroidism ; Hypothyroidism - physiopathology ; Internal Medicine ; Laboratory Medicine ; Light - adverse effects ; Male ; Melatonin ; Melatonin - metabolism ; Melatonin - therapeutic use ; Pathology ; Pineal Gland - metabolism ; Pineal Gland - physiopathology ; Rabbits ; Thyroid gland ; Thyroid Gland - metabolism ; Thyroid hormones ; Thyroid Hormones - blood</subject><ispartof>Bulletin of experimental biology and medicine, 2011-04, Vol.150 (6), p.753-755</ispartof><rights>Springer Science+Business Media, Inc. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c286z-11eeea2916b4cd7d5275386dc53cf098815d297be0e8114bf2af5701fb912b5f3</citedby><cites>FETCH-LOGICAL-c286z-11eeea2916b4cd7d5275386dc53cf098815d297be0e8114bf2af5701fb912b5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-011-1241-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-011-1241-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22235435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondarenko, L. A.</creatorcontrib><creatorcontrib>Sotnik, N. N.</creatorcontrib><creatorcontrib>Chagovets, E. M.</creatorcontrib><creatorcontrib>Sergienko, L. Yu</creatorcontrib><creatorcontrib>Cherevko, A. N.</creatorcontrib><title>Intensity of In Vitro Incorporation of 3H-Melatonin in the Thyroid Gland of Rabbits with Pineal Gland Hypofunction</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The structure and hormonal activity of the thyroid gland and its capacity to bind
3
H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called “latent hypothyroidism” and more intense binding of
3
H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - physiopathology</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Light - adverse effects</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - therapeutic use</subject><subject>Pathology</subject><subject>Pineal Gland - metabolism</subject><subject>Pineal Gland - physiopathology</subject><subject>Rabbits</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1DAUxYMo7uzoB_BFCoL71DU3adr0cVl0Z2BFkdXXkKbJNksnGZOUZebTm9JRXBBJIH_u71yScxB6A_gSMG4-RMAMmhIDlEAqKI_P0ApYQ0tOCDxHK5yhsuKcn6HzGB_mI67hJTojhFBWUbZCYeuSdtGmQ-FNsXXFD5uCzxvlw94Hmax3c4Vuys96lMk764o806CLu-EQvO2Lm1G6foa-ya6zKRaPNg3FV-u0HE_FzWHvzeTU3O4VemHkGPXr07pG3z99vLvelLdfbrbXV7elIrw-lgBaa0laqLtK9U3PSMMor3vFqDK45RxYT9qm01hzgKozRBrWYDBdC6Rjhq7RxdJ3H_zPScckdjYqPeYHaT9F0QKrKdQcZ_LdQt7LUQvrjE9BqpkWV5TVjEOVDVujy39QefR6Z5V32th8_0Tw_i_BkN1IQ_TjNJsQn4KwgCr4GIM2Yh_sToaDACzmpMWStMhJizlpccyat6ffTd1O938Uv6PNAFmAmEvuXgfx4KfgsuP_6foL7LOx4A</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Bondarenko, L. A.</creator><creator>Sotnik, N. N.</creator><creator>Chagovets, E. M.</creator><creator>Sergienko, L. Yu</creator><creator>Cherevko, A. N.</creator><general>Springer US</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Intensity of In Vitro Incorporation of 3H-Melatonin in the Thyroid Gland of Rabbits with Pineal Gland Hypofunction</title><author>Bondarenko, L. A. ; Sotnik, N. N. ; Chagovets, E. M. ; Sergienko, L. Yu ; Cherevko, A. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286z-11eeea2916b4cd7d5275386dc53cf098815d297be0e8114bf2af5701fb912b5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - physiopathology</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Light - adverse effects</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - therapeutic use</topic><topic>Pathology</topic><topic>Pineal Gland - metabolism</topic><topic>Pineal Gland - physiopathology</topic><topic>Rabbits</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondarenko, L. A.</creatorcontrib><creatorcontrib>Sotnik, N. N.</creatorcontrib><creatorcontrib>Chagovets, E. M.</creatorcontrib><creatorcontrib>Sergienko, L. Yu</creatorcontrib><creatorcontrib>Cherevko, A. N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondarenko, L. A.</au><au>Sotnik, N. N.</au><au>Chagovets, E. M.</au><au>Sergienko, L. Yu</au><au>Cherevko, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intensity of In Vitro Incorporation of 3H-Melatonin in the Thyroid Gland of Rabbits with Pineal Gland Hypofunction</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2011-04</date><risdate>2011</risdate><volume>150</volume><issue>6</issue><spage>753</spage><epage>755</epage><pages>753-755</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>The structure and hormonal activity of the thyroid gland and its capacity to bind
3
H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called “latent hypothyroidism” and more intense binding of
3
H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22235435</pmid><doi>10.1007/s10517-011-1241-z</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Biology Hypothyroidism Hypothyroidism - physiopathology Internal Medicine Laboratory Medicine Light - adverse effects Male Melatonin Melatonin - metabolism Melatonin - therapeutic use Pathology Pineal Gland - metabolism Pineal Gland - physiopathology Rabbits Thyroid gland Thyroid Gland - metabolism Thyroid hormones Thyroid Hormones - blood |
| title | Intensity of In Vitro Incorporation of 3H-Melatonin in the Thyroid Gland of Rabbits with Pineal Gland Hypofunction |
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