Optical Trapping of a Single Protein

We experimentally demonstrate the optical trapping of a single bovine serum albumin (BSA) molecule that has a hydrodynamic radius of 3.4 nm, using a double-nanohole in an Au film. The strong optical force in the trap not only stably traps the protein molecule but also unfolds it. The unfolding of th...

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Veröffentlicht in:	Nano letters 2012-01, Vol.12 (1), p.402-406
Hauptverfasser:	Pang, Yuanjie, Gordon, Reuven
Format:	Artikel
Sprache:	eng
Schlagworte:	Exact sciences and technology Fluid dynamics Fluid flow Fundamental areas of phenomenology (including applications) Hydrodynamics Mechanical effects of light on atoms, molecules, electrons, and ions Nanostructure Optical trapping Optical Tweezers Optics Physics Protein Denaturation Protein Folding Proteins Quantum optics Serum Albumin, Bovine - isolation & purification Serum Albumin, Bovine - ultrastructure Signal to noise ratio Trapping
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