Anti-tumor Effects of All-trans Retinoic Acid are Enhanced by Genistein

The effects of all-trans retinoic acid (ATRA) on cancer are complex. ATRA has anti-cancer effects as it promotes cancer cell differentiation. However, ATRA also up-regulates expression of vascular endothelial growth factor (VEGF) in cancer cells, which leads to angiogenesis and can, thus, facilitate...

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Veröffentlicht in:	Cell biochemistry and biophysics 2012, Vol.62 (1), p.177-184
Hauptverfasser:	Zhou, Ren-Jie, Yang, Xue-Qin, Wang, Dong, Zhou, Qian, Xia, Lei, Li, Meng-Xia, Zeng, Lin-Li, Wang, Ge, Yang, Zhen-Zhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Antineoplastic Agents - pharmacology Apoptosis - drug effects Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Cell Cycle - drug effects Cell differentiation Cell Line, Tumor Drug Synergism G1 Phase Cell Cycle Checkpoints G2 Phase Cell Cycle Checkpoints Genistein - pharmacology Humans Life Sciences Lung cancer Lung Neoplasms - pathology M Phase Cell Cycle Checkpoints Original Paper Pharmacology/Toxicology Soybeans Synergistic effect Tretinoin - pharmacology Up-Regulation - drug effects Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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