Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure
Purpose Assessment of circulating levels of collagenderived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-rel...
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| Veröffentlicht in: | Quality of life research 2012-02, Vol.21 (1), p.143-153 |
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| creator | Chatzikyriakou, Sofia V. Tziakas, Dimitrios N. Chalikias, Georgios K. Stakos, Dimitrios Papazoglou, Dimitrios Lantzouraki, Asimina Thomaidi, Adina Boudoulas, Harisios Konstantinides, Stavros |
| description | Purpose Assessment of circulating levels of collagenderived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL. Methods We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)—a marker of collagen type I degradation—were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ). Results CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis. Conclusion Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF.These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF. |
| doi_str_mv | 10.1007/s11136-011-9932-5 |
| format | Article |
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The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL. Methods We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)—a marker of collagen type I degradation—were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ). Results CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis. Conclusion Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF.These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF.</description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-011-9932-5</identifier><identifier>PMID: 21598062</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Aged ; Biomarkers ; Biomarkers - blood ; Cardiology ; Cardiomyopathy ; Cardiovascular disease ; CLINICAL AND POLICY APPLICATIONS ; Collagen ; Collagen - metabolism ; Collagen Type I - blood ; Collagens ; Congestive heart failure ; Consent ; Etiology ; Female ; Fibrosis ; Health Status ; Heart ; Heart failure ; Heart Failure - blood ; Heart Failure - physiopathology ; Humans ; Hypertension ; Ischemia ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Peptides ; Peptides - blood ; Public Health ; Quality of Life ; Quality of Life Research ; Questionnaires ; Regression analysis ; Sociology ; Surveys and Questionnaires</subject><ispartof>Quality of life research, 2012-02, Vol.21 (1), p.143-153</ispartof><rights>2012 Springer</rights><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-9be7cc658f64058aca8260e6b7aa8a92fa6d6aab00c673b9204993769d8fd7d63</citedby><cites>FETCH-LOGICAL-c392t-9be7cc658f64058aca8260e6b7aa8a92fa6d6aab00c673b9204993769d8fd7d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41411320$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41411320$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,41464,42533,51294,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21598062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatzikyriakou, Sofia V.</creatorcontrib><creatorcontrib>Tziakas, Dimitrios N.</creatorcontrib><creatorcontrib>Chalikias, Georgios K.</creatorcontrib><creatorcontrib>Stakos, Dimitrios</creatorcontrib><creatorcontrib>Papazoglou, Dimitrios</creatorcontrib><creatorcontrib>Lantzouraki, Asimina</creatorcontrib><creatorcontrib>Thomaidi, Adina</creatorcontrib><creatorcontrib>Boudoulas, Harisios</creatorcontrib><creatorcontrib>Konstantinides, Stavros</creatorcontrib><title>Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description>Purpose Assessment of circulating levels of collagenderived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL. Methods We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)—a marker of collagen type I degradation—were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ). Results CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis. Conclusion Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF.These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF.</description><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>CLINICAL AND POLICY APPLICATIONS</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Collagen Type I - blood</subject><subject>Collagens</subject><subject>Congestive heart failure</subject><subject>Consent</subject><subject>Etiology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Health Status</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Peptides</subject><subject>Peptides - 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blood</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>CLINICAL AND POLICY APPLICATIONS</topic><topic>Collagen</topic><topic>Collagen - metabolism</topic><topic>Collagen Type I - blood</topic><topic>Collagens</topic><topic>Congestive heart failure</topic><topic>Consent</topic><topic>Etiology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Health Status</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Peptides</topic><topic>Peptides - blood</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Quality of Life Research</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Sociology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chatzikyriakou, Sofia V.</creatorcontrib><creatorcontrib>Tziakas, Dimitrios N.</creatorcontrib><creatorcontrib>Chalikias, Georgios K.</creatorcontrib><creatorcontrib>Stakos, Dimitrios</creatorcontrib><creatorcontrib>Papazoglou, Dimitrios</creatorcontrib><creatorcontrib>Lantzouraki, Asimina</creatorcontrib><creatorcontrib>Thomaidi, Adina</creatorcontrib><creatorcontrib>Boudoulas, Harisios</creatorcontrib><creatorcontrib>Konstantinides, Stavros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Quality of life research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chatzikyriakou, Sofia V.</au><au>Tziakas, Dimitrios N.</au><au>Chalikias, Georgios K.</au><au>Stakos, Dimitrios</au><au>Papazoglou, Dimitrios</au><au>Lantzouraki, Asimina</au><au>Thomaidi, Adina</au><au>Boudoulas, Harisios</au><au>Konstantinides, Stavros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure</atitle><jtitle>Quality of life research</jtitle><stitle>Qual Life Res</stitle><addtitle>Qual Life Res</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>21</volume><issue>1</issue><spage>143</spage><epage>153</epage><pages>143-153</pages><issn>0962-9343</issn><eissn>1573-2649</eissn><abstract>Purpose Assessment of circulating levels of collagenderived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL. Methods We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)—a marker of collagen type I degradation—were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ). Results CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis. Conclusion Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF.These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>21598062</pmid><doi>10.1007/s11136-011-9932-5</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Biomarkers Biomarkers - blood Cardiology Cardiomyopathy Cardiovascular disease CLINICAL AND POLICY APPLICATIONS Collagen Collagen - metabolism Collagen Type I - blood Collagens Congestive heart failure Consent Etiology Female Fibrosis Health Status Heart Heart failure Heart Failure - blood Heart Failure - physiopathology Humans Hypertension Ischemia Male Medicine Medicine & Public Health Metabolism Middle Aged Peptides Peptides - blood Public Health Quality of Life Quality of Life Research Questionnaires Regression analysis Sociology Surveys and Questionnaires |
| title | Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure |
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