Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice
Highlights ► Yeast Pichia pastoris produced cholera toxin B subunit (CTB) as a glycoprotein. ► Oligosaccharide (OS) extends from the lateral circumference of the CTB pentamer ring. ► The OS chain was exploited as an anchoring scaffold for a malaria antigen (MSP1). ► MSP1 fused via the OS chain induc...
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| Veröffentlicht in: | Vaccine 2012-01, Vol.30 (5), p.948-958 |
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| container_issue | 5 |
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| container_title | Vaccine |
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| creator | Miyata, Takeshi Harakuni, Tetsuya Taira, Toki Matsuzaki, Goro Arakawa, Takeshi |
| description | Highlights ► Yeast Pichia pastoris produced cholera toxin B subunit (CTB) as a glycoprotein. ► Oligosaccharide (OS) extends from the lateral circumference of the CTB pentamer ring. ► The OS chain was exploited as an anchoring scaffold for a malaria antigen (MSP1). ► MSP1 fused via the OS chain induced increased protection against malaria infection. ► Increased protection was due to higher Ag loading capacity of the CTB glycoprotein. |
| doi_str_mv | 10.1016/j.vaccine.2011.11.059 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-26f2ad3513bfc32b7c516efed86896f6ab6337bf399979039b0a23f3518133df3</citedby><cites>FETCH-LOGICAL-c509t-26f2ad3513bfc32b7c516efed86896f6ab6337bf399979039b0a23f3518133df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vaccine.2011.11.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22119928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyata, Takeshi</creatorcontrib><creatorcontrib>Harakuni, Tetsuya</creatorcontrib><creatorcontrib>Taira, Toki</creatorcontrib><creatorcontrib>Matsuzaki, Goro</creatorcontrib><creatorcontrib>Arakawa, Takeshi</creatorcontrib><title>Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► Yeast Pichia pastoris produced cholera toxin B subunit (CTB) as a glycoprotein. ► Oligosaccharide (OS) extends from the lateral circumference of the CTB pentamer ring. ► The OS chain was exploited as an anchoring scaffold for a malaria antigen (MSP1). ► MSP1 fused via the OS chain induced increased protection against malaria infection. ► Increased protection was due to higher Ag loading capacity of the CTB glycoprotein.</description><subject>Administration, Intranasal</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>antigens</subject><subject>binding capacity</subject><subject>cholera toxin</subject><subject>Cholera Toxin - genetics</subject><subject>Cholera Toxin - immunology</subject><subject>CTB</subject><subject>Delivery system</subject><subject>Disease Models, Animal</subject><subject>edema</subject><subject>Female</subject><subject>gangliosides</subject><subject>glycoproteins</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - immunology</subject><subject>glycosylation</subject><subject>immunity</subject><subject>immunization</subject><subject>Injections, Subcutaneous</subject><subject>Malaria</subject><subject>Malaria - immunology</subject><subject>Malaria - prevention & control</subject><subject>Malaria Vaccines - administration & dosage</subject><subject>Malaria Vaccines - genetics</subject><subject>Malaria Vaccines - immunology</subject><subject>Merozoite Surface Protein 1 - genetics</subject><subject>Merozoite Surface Protein 1 - immunology</subject><subject>merozoites</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>oligosaccharides</subject><subject>parasites</subject><subject>Pichia - genetics</subject><subject>Pichia - metabolism</subject><subject>Pichia pastoris</subject><subject>Plasmodium yoelii</subject><subject>Plasmodium yoelii - genetics</subject><subject>Plasmodium yoelii - immunology</subject><subject>protein bodies</subject><subject>Subunit vaccine</subject><subject>Survival Analysis</subject><subject>vaccines</subject><subject>Vaccines, Conjugate - administration & dosage</subject><subject>Vaccines, Conjugate - genetics</subject><subject>Vaccines, Conjugate - immunology</subject><subject>Vaccines, Synthetic - administration & dosage</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>yeasts</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUkuP0zAQjhCIXQo_AfCNU4ofdRpfQLDiJS0CaVlpb5bjjNspTty1k2rD7-QH4dDCgQvSSH7oe4zmm6J4yuiSUVa93C0PxlrsYckpY8tcVKp7xTmr16LkktX3i3PKq1W5YvTmrHiU0o5SKgVTD4szzhlTitfnxc_PEMOPgAOQNEZnLJB9DANgXzISHPnqTepCi2NHpgAekbgxQUsOaIjpSfC4CSk3sjURWyBdQBimmWi3wUM0ZAh32JO3Wb0ZexzIxk82nCwI3O0jpFkvPyYwaciXdrT54zfEDngAgl03UydiNgb7jPEwbI0nnfHZ1WSKm5Ghn1U6tPC4eOCMT_DkdC6K6_fvvl18LC-_fPh08eaytJKqoeSV46YVkonGWcGbtZWsAgdtXdWqcpVpKiHWjRNKqbWiQjXUcOEyoWZCtE4sihdH3dzs7Qhp0B0mC96bHsKYtGKy4msp6oyUR6SNIaUITu8jdiZOmlE956l3-pSnnvPUuXKemffs5DA2HbR_WX8CzIDnR4AzQZtNxKSvr7KCpJSteJXNF8XrIwLyJA4IUSeL0OcZY8xj023A_zbx6h8F67FHa_x3mCDtwhj7PGbNdOKa6qt57eatY1mzlvJG_AJssthq</recordid><startdate>20120120</startdate><enddate>20120120</enddate><creator>Miyata, Takeshi</creator><creator>Harakuni, Tetsuya</creator><creator>Taira, Toki</creator><creator>Matsuzaki, Goro</creator><creator>Arakawa, Takeshi</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120120</creationdate><title>Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice</title><author>Miyata, Takeshi ; Harakuni, Tetsuya ; Taira, Toki ; Matsuzaki, Goro ; Arakawa, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-26f2ad3513bfc32b7c516efed86896f6ab6337bf399979039b0a23f3518133df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Intranasal</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>antigens</topic><topic>binding capacity</topic><topic>cholera toxin</topic><topic>Cholera Toxin - genetics</topic><topic>Cholera Toxin - immunology</topic><topic>CTB</topic><topic>Delivery system</topic><topic>Disease Models, Animal</topic><topic>edema</topic><topic>Female</topic><topic>gangliosides</topic><topic>glycoproteins</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - immunology</topic><topic>glycosylation</topic><topic>immunity</topic><topic>immunization</topic><topic>Injections, Subcutaneous</topic><topic>Malaria</topic><topic>Malaria - immunology</topic><topic>Malaria - prevention & control</topic><topic>Malaria Vaccines - administration & dosage</topic><topic>Malaria Vaccines - genetics</topic><topic>Malaria Vaccines - immunology</topic><topic>Merozoite Surface Protein 1 - genetics</topic><topic>Merozoite Surface Protein 1 - immunology</topic><topic>merozoites</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>oligosaccharides</topic><topic>parasites</topic><topic>Pichia - genetics</topic><topic>Pichia - metabolism</topic><topic>Pichia pastoris</topic><topic>Plasmodium yoelii</topic><topic>Plasmodium yoelii - genetics</topic><topic>Plasmodium yoelii - immunology</topic><topic>protein bodies</topic><topic>Subunit vaccine</topic><topic>Survival Analysis</topic><topic>vaccines</topic><topic>Vaccines, Conjugate - administration & dosage</topic><topic>Vaccines, Conjugate - genetics</topic><topic>Vaccines, Conjugate - immunology</topic><topic>Vaccines, Synthetic - administration & dosage</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyata, Takeshi</creatorcontrib><creatorcontrib>Harakuni, Tetsuya</creatorcontrib><creatorcontrib>Taira, Toki</creatorcontrib><creatorcontrib>Matsuzaki, Goro</creatorcontrib><creatorcontrib>Arakawa, Takeshi</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyata, Takeshi</au><au>Harakuni, Tetsuya</au><au>Taira, Toki</au><au>Matsuzaki, Goro</au><au>Arakawa, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2012-01-20</date><risdate>2012</risdate><volume>30</volume><issue>5</issue><spage>948</spage><epage>958</epage><pages>948-958</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights ► Yeast Pichia pastoris produced cholera toxin B subunit (CTB) as a glycoprotein. ► Oligosaccharide (OS) extends from the lateral circumference of the CTB pentamer ring. ► The OS chain was exploited as an anchoring scaffold for a malaria antigen (MSP1). ► MSP1 fused via the OS chain induced increased protection against malaria infection. ► Increased protection was due to higher Ag loading capacity of the CTB glycoprotein.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>22119928</pmid><doi>10.1016/j.vaccine.2011.11.059</doi><tpages>11</tpages></addata></record> |
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| ispartof | Vaccine, 2012-01, Vol.30 (5), p.948-958 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Administration, Intranasal Allergy and Immunology Animals antigens binding capacity cholera toxin Cholera Toxin - genetics Cholera Toxin - immunology CTB Delivery system Disease Models, Animal edema Female gangliosides glycoproteins Glycoproteins - genetics Glycoproteins - immunology glycosylation immunity immunization Injections, Subcutaneous Malaria Malaria - immunology Malaria - prevention & control Malaria Vaccines - administration & dosage Malaria Vaccines - genetics Malaria Vaccines - immunology Merozoite Surface Protein 1 - genetics Merozoite Surface Protein 1 - immunology merozoites Mice Mice, Inbred BALB C Mice, Inbred C57BL oligosaccharides parasites Pichia - genetics Pichia - metabolism Pichia pastoris Plasmodium yoelii Plasmodium yoelii - genetics Plasmodium yoelii - immunology protein bodies Subunit vaccine Survival Analysis vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - genetics Vaccines, Conjugate - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology yeasts |
| title | Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice |
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