Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers
Objectivesp,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profi...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2012-01, Vol.69 (1), p.5-11 |
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| creator | Blanco-Muñoz, Julia Lacasaña, Marina Aguilar-Garduño, Clemente Rodríguez-Barranco, Miguel Bassol, Susana Cebrián, Mariano E López-Flores, Inmaculada Ruiz-Pérez, Isabel |
| description | Objectivesp,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profile in Mexican male flower growers.MethodsA longitudinal study was carried out in a population of men working in the production of flowers and ornamental plants in two Mexican states during July–October 2004 (rainy season) and December 2004–May 2005 (dry season). A questionnaire including information on socioeconomic characteristics, tobacco and alcohol use, presence of chronic and acute diseases, occupational history and anthropometry was used and blood and urine samples were obtained. Serum levels of p,p'-DDE were analysed by gas chromatography; FSH, LH, testosterone, oestradiol, inhibin B and prolactin levels were measured by enzymatic immunoassay. Urinary levels of dialkylphosphates (DAPs) were analysed by gas chromatography. Associations between serum levels of p,p'-DDE and male reproductive hormones (both transformed to their natural logarithm) were evaluated using multivariate generalised estimating equation (GEE) models.ResultsMedian p,p'-DDE levels were 677.2 ng/g lipid (range 9.4–12 696.5) during the rainy season and 626.7 ng/g lipid (range 9.4–13 668.1) during the dry season. After adjusting for potential confounders (age, body mass index, state of residence and DAPs), p,p'-DDE levels were negatively associated with prolactin (β=−0.04; 95% CI −0.07 to −0.008) and testosterone (β=0.04; 95% CI −0.08 to 0.005) and positively with inhibin B (β=0.11; 95% CI 0.02 to 0.21).ConclusionThese results indicate that p,p'-DDE can affect hypothalamic–pituitary–gonadal axis function in humans. |
| doi_str_mv | 10.1136/oem.2010.059667 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_915494128</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>41408476</jstor_id><sourcerecordid>41408476</sourcerecordid><originalsourceid>FETCH-LOGICAL-b481t-fd6973639cddef1cd7e97fedcdd14e981a7916eca09a7ab0fa5e219cd52c87933</originalsourceid><addsrcrecordid>eNqNkc1v1DAQxSMEoh9w5gSyhKpKqGk9dhzHx2p3KRXl4wBcLa8zhixJHOxEXf57vMqySFzgNB69n2fm6WXZM6CXALy88thdMpo6KlRZygfZMRSS5lKx8mF6cwE5lQBH2UmMG0qBS84eZ0cMhKgKyY-zjyvn0I7EO4LbwccpIBk9GS6G83y5XBHfk860SL750PkeyRC8a1Lf9OQdbhtreuJaf4-BfA27Ep9kj5xpIz7d19Ps8-vVp8Wb_O7Dze3i-i5fFxWMuatLJXnJla1rdGBriUo6rFMLBaoKjFRQojVUGWnW1BmBDBItmK2k4vw0O5_npot-TBhH3TXRYtuaHv0UtQJRqAJY9R8kJJCDSuTLv8iNn0KfbGiQFXAqBROJupopG3yMAZ0eQtOZ8FMD1btUdEpF71LRcyrpx4v93GndYX3gf8eQgLM9YKI1rQumt038wwmWHFe71c9nbhNHHw56AQVNc8qk57PexBG3B92E7zqdIYV-_2Whbwpasrd8qReJfzXz627zTxe_ANp0uPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781307525</pqid></control><display><type>article</type><title>Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Blanco-Muñoz, Julia ; Lacasaña, Marina ; Aguilar-Garduño, Clemente ; Rodríguez-Barranco, Miguel ; Bassol, Susana ; Cebrián, Mariano E ; López-Flores, Inmaculada ; Ruiz-Pérez, Isabel</creator><creatorcontrib>Blanco-Muñoz, Julia ; Lacasaña, Marina ; Aguilar-Garduño, Clemente ; Rodríguez-Barranco, Miguel ; Bassol, Susana ; Cebrián, Mariano E ; López-Flores, Inmaculada ; Ruiz-Pérez, Isabel</creatorcontrib><description>Objectivesp,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profile in Mexican male flower growers.MethodsA longitudinal study was carried out in a population of men working in the production of flowers and ornamental plants in two Mexican states during July–October 2004 (rainy season) and December 2004–May 2005 (dry season). A questionnaire including information on socioeconomic characteristics, tobacco and alcohol use, presence of chronic and acute diseases, occupational history and anthropometry was used and blood and urine samples were obtained. Serum levels of p,p'-DDE were analysed by gas chromatography; FSH, LH, testosterone, oestradiol, inhibin B and prolactin levels were measured by enzymatic immunoassay. Urinary levels of dialkylphosphates (DAPs) were analysed by gas chromatography. Associations between serum levels of p,p'-DDE and male reproductive hormones (both transformed to their natural logarithm) were evaluated using multivariate generalised estimating equation (GEE) models.ResultsMedian p,p'-DDE levels were 677.2 ng/g lipid (range 9.4–12 696.5) during the rainy season and 626.7 ng/g lipid (range 9.4–13 668.1) during the dry season. After adjusting for potential confounders (age, body mass index, state of residence and DAPs), p,p'-DDE levels were negatively associated with prolactin (β=−0.04; 95% CI −0.07 to −0.008) and testosterone (β=0.04; 95% CI −0.08 to 0.005) and positively with inhibin B (β=0.11; 95% CI 0.02 to 0.21).ConclusionThese results indicate that p,p'-DDE can affect hypothalamic–pituitary–gonadal axis function in humans.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.2010.059667</identifier><identifier>PMID: 21558473</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Agriculture ; Analysis of Variance ; Androgens ; Biological and medical sciences ; Body mass index ; Chemical hazards ; DDE ; Dichlorodiphenyl Dichloroethylene - blood ; Dry season ; Dry seasons ; endocrine disorders ; Environmental Exposure ; Environmental Pollutants - blood ; epidemiology ; flower growers ; Flowers ; Gas chromatography ; Gonadal Hormones - blood ; Gonadotropins, Pituitary - blood ; Hormonal effects ; Hormone metabolism ; Hormones ; Humans ; Hypotheses ; Insecticides - blood ; Longitudinal Studies ; Malaria ; Male ; male hormonal profile ; male reproduction ; Medical sciences ; Metabolites ; Mexico ; Nitrous oxide ; organochlorides ; Ornamental plants ; p' DDE ; Pest control ; Pesticides ; Pesticides, fertilizers and other agrochemicals toxicology ; Public health ; Questionnaires ; Rainy season ; Rainy seasons ; Reproductive system ; Seasons ; Sperm ; Studies ; Testosterone ; Toxicology ; Urine ; Workers ; Workplace</subject><ispartof>Occupational and environmental medicine (London, England), 2012-01, Vol.69 (1), p.5-11</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2012 BMJ Publishing Group</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b481t-fd6973639cddef1cd7e97fedcdd14e981a7916eca09a7ab0fa5e219cd52c87933</citedby><cites>FETCH-LOGICAL-b481t-fd6973639cddef1cd7e97fedcdd14e981a7916eca09a7ab0fa5e219cd52c87933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://oem.bmj.com/content/69/1/5.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://oem.bmj.com/content/69/1/5.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,799,3183,4010,23550,27900,27901,27902,57992,58225,77343,77374</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25293385$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21558473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanco-Muñoz, Julia</creatorcontrib><creatorcontrib>Lacasaña, Marina</creatorcontrib><creatorcontrib>Aguilar-Garduño, Clemente</creatorcontrib><creatorcontrib>Rodríguez-Barranco, Miguel</creatorcontrib><creatorcontrib>Bassol, Susana</creatorcontrib><creatorcontrib>Cebrián, Mariano E</creatorcontrib><creatorcontrib>López-Flores, Inmaculada</creatorcontrib><creatorcontrib>Ruiz-Pérez, Isabel</creatorcontrib><title>Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>Objectivesp,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profile in Mexican male flower growers.MethodsA longitudinal study was carried out in a population of men working in the production of flowers and ornamental plants in two Mexican states during July–October 2004 (rainy season) and December 2004–May 2005 (dry season). A questionnaire including information on socioeconomic characteristics, tobacco and alcohol use, presence of chronic and acute diseases, occupational history and anthropometry was used and blood and urine samples were obtained. Serum levels of p,p'-DDE were analysed by gas chromatography; FSH, LH, testosterone, oestradiol, inhibin B and prolactin levels were measured by enzymatic immunoassay. Urinary levels of dialkylphosphates (DAPs) were analysed by gas chromatography. Associations between serum levels of p,p'-DDE and male reproductive hormones (both transformed to their natural logarithm) were evaluated using multivariate generalised estimating equation (GEE) models.ResultsMedian p,p'-DDE levels were 677.2 ng/g lipid (range 9.4–12 696.5) during the rainy season and 626.7 ng/g lipid (range 9.4–13 668.1) during the dry season. After adjusting for potential confounders (age, body mass index, state of residence and DAPs), p,p'-DDE levels were negatively associated with prolactin (β=−0.04; 95% CI −0.07 to −0.008) and testosterone (β=0.04; 95% CI −0.08 to 0.005) and positively with inhibin B (β=0.11; 95% CI 0.02 to 0.21).ConclusionThese results indicate that p,p'-DDE can affect hypothalamic–pituitary–gonadal axis function in humans.</description><subject>Adult</subject><subject>Agriculture</subject><subject>Analysis of Variance</subject><subject>Androgens</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Chemical hazards</subject><subject>DDE</subject><subject>Dichlorodiphenyl Dichloroethylene - blood</subject><subject>Dry season</subject><subject>Dry seasons</subject><subject>endocrine disorders</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - blood</subject><subject>epidemiology</subject><subject>flower growers</subject><subject>Flowers</subject><subject>Gas chromatography</subject><subject>Gonadal Hormones - blood</subject><subject>Gonadotropins, Pituitary - blood</subject><subject>Hormonal effects</subject><subject>Hormone metabolism</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Insecticides - blood</subject><subject>Longitudinal Studies</subject><subject>Malaria</subject><subject>Male</subject><subject>male hormonal profile</subject><subject>male reproduction</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Mexico</subject><subject>Nitrous oxide</subject><subject>organochlorides</subject><subject>Ornamental plants</subject><subject>p' DDE</subject><subject>Pest control</subject><subject>Pesticides</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Rainy season</subject><subject>Rainy seasons</subject><subject>Reproductive system</subject><subject>Seasons</subject><subject>Sperm</subject><subject>Studies</subject><subject>Testosterone</subject><subject>Toxicology</subject><subject>Urine</subject><subject>Workers</subject><subject>Workplace</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1v1DAQxSMEoh9w5gSyhKpKqGk9dhzHx2p3KRXl4wBcLa8zhixJHOxEXf57vMqySFzgNB69n2fm6WXZM6CXALy88thdMpo6KlRZygfZMRSS5lKx8mF6cwE5lQBH2UmMG0qBS84eZ0cMhKgKyY-zjyvn0I7EO4LbwccpIBk9GS6G83y5XBHfk860SL750PkeyRC8a1Lf9OQdbhtreuJaf4-BfA27Ep9kj5xpIz7d19Ps8-vVp8Wb_O7Dze3i-i5fFxWMuatLJXnJla1rdGBriUo6rFMLBaoKjFRQojVUGWnW1BmBDBItmK2k4vw0O5_npot-TBhH3TXRYtuaHv0UtQJRqAJY9R8kJJCDSuTLv8iNn0KfbGiQFXAqBROJupopG3yMAZ0eQtOZ8FMD1btUdEpF71LRcyrpx4v93GndYX3gf8eQgLM9YKI1rQumt038wwmWHFe71c9nbhNHHw56AQVNc8qk57PexBG3B92E7zqdIYV-_2Whbwpasrd8qReJfzXz627zTxe_ANp0uPw</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Blanco-Muñoz, Julia</creator><creator>Lacasaña, Marina</creator><creator>Aguilar-Garduño, Clemente</creator><creator>Rodríguez-Barranco, Miguel</creator><creator>Bassol, Susana</creator><creator>Cebrián, Mariano E</creator><creator>López-Flores, Inmaculada</creator><creator>Ruiz-Pérez, Isabel</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201201</creationdate><title>Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers</title><author>Blanco-Muñoz, Julia ; Lacasaña, Marina ; Aguilar-Garduño, Clemente ; Rodríguez-Barranco, Miguel ; Bassol, Susana ; Cebrián, Mariano E ; López-Flores, Inmaculada ; Ruiz-Pérez, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b481t-fd6973639cddef1cd7e97fedcdd14e981a7916eca09a7ab0fa5e219cd52c87933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Agriculture</topic><topic>Analysis of Variance</topic><topic>Androgens</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Chemical hazards</topic><topic>DDE</topic><topic>Dichlorodiphenyl Dichloroethylene - blood</topic><topic>Dry season</topic><topic>Dry seasons</topic><topic>endocrine disorders</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - blood</topic><topic>epidemiology</topic><topic>flower growers</topic><topic>Flowers</topic><topic>Gas chromatography</topic><topic>Gonadal Hormones - blood</topic><topic>Gonadotropins, Pituitary - blood</topic><topic>Hormonal effects</topic><topic>Hormone metabolism</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Insecticides - blood</topic><topic>Longitudinal Studies</topic><topic>Malaria</topic><topic>Male</topic><topic>male hormonal profile</topic><topic>male reproduction</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Mexico</topic><topic>Nitrous oxide</topic><topic>organochlorides</topic><topic>Ornamental plants</topic><topic>p' DDE</topic><topic>Pest control</topic><topic>Pesticides</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Public health</topic><topic>Questionnaires</topic><topic>Rainy season</topic><topic>Rainy seasons</topic><topic>Reproductive system</topic><topic>Seasons</topic><topic>Sperm</topic><topic>Studies</topic><topic>Testosterone</topic><topic>Toxicology</topic><topic>Urine</topic><topic>Workers</topic><topic>Workplace</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanco-Muñoz, Julia</creatorcontrib><creatorcontrib>Lacasaña, Marina</creatorcontrib><creatorcontrib>Aguilar-Garduño, Clemente</creatorcontrib><creatorcontrib>Rodríguez-Barranco, Miguel</creatorcontrib><creatorcontrib>Bassol, Susana</creatorcontrib><creatorcontrib>Cebrián, Mariano E</creatorcontrib><creatorcontrib>López-Flores, Inmaculada</creatorcontrib><creatorcontrib>Ruiz-Pérez, Isabel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanco-Muñoz, Julia</au><au>Lacasaña, Marina</au><au>Aguilar-Garduño, Clemente</au><au>Rodríguez-Barranco, Miguel</au><au>Bassol, Susana</au><au>Cebrián, Mariano E</au><au>López-Flores, Inmaculada</au><au>Ruiz-Pérez, Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2012-01</date><risdate>2012</risdate><volume>69</volume><issue>1</issue><spage>5</spage><epage>11</epage><pages>5-11</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>Objectivesp,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profile in Mexican male flower growers.MethodsA longitudinal study was carried out in a population of men working in the production of flowers and ornamental plants in two Mexican states during July–October 2004 (rainy season) and December 2004–May 2005 (dry season). A questionnaire including information on socioeconomic characteristics, tobacco and alcohol use, presence of chronic and acute diseases, occupational history and anthropometry was used and blood and urine samples were obtained. Serum levels of p,p'-DDE were analysed by gas chromatography; FSH, LH, testosterone, oestradiol, inhibin B and prolactin levels were measured by enzymatic immunoassay. Urinary levels of dialkylphosphates (DAPs) were analysed by gas chromatography. Associations between serum levels of p,p'-DDE and male reproductive hormones (both transformed to their natural logarithm) were evaluated using multivariate generalised estimating equation (GEE) models.ResultsMedian p,p'-DDE levels were 677.2 ng/g lipid (range 9.4–12 696.5) during the rainy season and 626.7 ng/g lipid (range 9.4–13 668.1) during the dry season. After adjusting for potential confounders (age, body mass index, state of residence and DAPs), p,p'-DDE levels were negatively associated with prolactin (β=−0.04; 95% CI −0.07 to −0.008) and testosterone (β=0.04; 95% CI −0.08 to 0.005) and positively with inhibin B (β=0.11; 95% CI 0.02 to 0.21).ConclusionThese results indicate that p,p'-DDE can affect hypothalamic–pituitary–gonadal axis function in humans.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>21558473</pmid><doi>10.1136/oem.2010.059667</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-0711 |
| ispartof | Occupational and environmental medicine (London, England), 2012-01, Vol.69 (1), p.5-11 |
| issn | 1351-0711 1470-7926 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_915494128 |
| source | Jstor Complete Legacy; MEDLINE; BMJ Journals - NESLi2 |
| subjects | Adult Agriculture Analysis of Variance Androgens Biological and medical sciences Body mass index Chemical hazards DDE Dichlorodiphenyl Dichloroethylene - blood Dry season Dry seasons endocrine disorders Environmental Exposure Environmental Pollutants - blood epidemiology flower growers Flowers Gas chromatography Gonadal Hormones - blood Gonadotropins, Pituitary - blood Hormonal effects Hormone metabolism Hormones Humans Hypotheses Insecticides - blood Longitudinal Studies Malaria Male male hormonal profile male reproduction Medical sciences Metabolites Mexico Nitrous oxide organochlorides Ornamental plants p' DDE Pest control Pesticides Pesticides, fertilizers and other agrochemicals toxicology Public health Questionnaires Rainy season Rainy seasons Reproductive system Seasons Sperm Studies Testosterone Toxicology Urine Workers Workplace |
| title | Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers |
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