Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET–MRI fusion imaging
The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging. Fluorodeoxyglucose positron emission tomography (PET) and magnetic...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2012-01, Vol.59 (2), p.1094-1097 |
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| creator | Son, Young-Don Cho, Zang-Hee Kim, Hang-Keun Choi, Eun-Jung Lee, Sang-Yoon Chi, Je-Geun Park, Chan-Woong Kim, Young-Bo |
| description | The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging.
Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) were performed in seven healthy subjects using a new PET–MRI, which consists of a high-resolution research tomograph (HRRT) PET and 7.0T-MRI. Glucose metabolism of raphe nuclei was semiquantitatively measured and identified along the midline brainstem region in vivo.
Midline nuclei clustered in four groups appeared to be the raphe nuclei and could be clearly visualized; specifically, we identified the groups as the dorsal raphe, raphe reticularis centralis superior, raphe pontis, and raphe magnus group.
FDG imaging of the midline raphe nuclei in vivo could potentially be an important tool for investigating brain diseases as well as conducting functional brain studies in the context of sleep disorders, depression, and neurodegenerative disease.
► The brainstem was imaged using high-resolution PET–MRI fusion system. ► Midline raphe-like nuclei were measured by FDG PET image. ► Anatomical landmarks provided by MRI helped identification of the nuclei. ► Finding of the raphe can be useful for studying serotoninergic function. |
| doi_str_mv | 10.1016/j.neuroimage.2011.09.036 |
| format | Article |
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Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) were performed in seven healthy subjects using a new PET–MRI, which consists of a high-resolution research tomograph (HRRT) PET and 7.0T-MRI. Glucose metabolism of raphe nuclei was semiquantitatively measured and identified along the midline brainstem region in vivo.
Midline nuclei clustered in four groups appeared to be the raphe nuclei and could be clearly visualized; specifically, we identified the groups as the dorsal raphe, raphe reticularis centralis superior, raphe pontis, and raphe magnus group.
FDG imaging of the midline raphe nuclei in vivo could potentially be an important tool for investigating brain diseases as well as conducting functional brain studies in the context of sleep disorders, depression, and neurodegenerative disease.
► The brainstem was imaged using high-resolution PET–MRI fusion system. ► Midline raphe-like nuclei were measured by FDG PET image. ► Anatomical landmarks provided by MRI helped identification of the nuclei. ► Finding of the raphe can be useful for studying serotoninergic function.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2011.09.036</identifier><identifier>PMID: 21963920</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Brain research ; Brain stem ; Brainstem ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Fusion imaging ; Glucose - metabolism ; Humans ; Ligands ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Metabolic Clearance Rate ; Metabolism ; NMR ; Nuclear magnetic resonance ; PET–MRI ; Positron-Emission Tomography - methods ; Radiopharmaceuticals - pharmacokinetics ; Raphe nuclei ; Raphe Nuclei - diagnostic imaging ; Raphe Nuclei - metabolism ; Raphe Nuclei - pathology ; Serotonin ; Studies ; Subtraction Technique ; Tissue Distribution ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2012-01, Vol.59 (2), p.1094-1097</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 16, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-346af681931fc19b11b0ae0f07aa04a128a72e98ec156ae8eb8769ad07c5b9563</citedby><cites>FETCH-LOGICAL-c499t-346af681931fc19b11b0ae0f07aa04a128a72e98ec156ae8eb8769ad07c5b9563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811911010846$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21963920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Young-Don</creatorcontrib><creatorcontrib>Cho, Zang-Hee</creatorcontrib><creatorcontrib>Kim, Hang-Keun</creatorcontrib><creatorcontrib>Choi, Eun-Jung</creatorcontrib><creatorcontrib>Lee, Sang-Yoon</creatorcontrib><creatorcontrib>Chi, Je-Geun</creatorcontrib><creatorcontrib>Park, Chan-Woong</creatorcontrib><creatorcontrib>Kim, Young-Bo</creatorcontrib><title>Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET–MRI fusion imaging</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging.
Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) were performed in seven healthy subjects using a new PET–MRI, which consists of a high-resolution research tomograph (HRRT) PET and 7.0T-MRI. Glucose metabolism of raphe nuclei was semiquantitatively measured and identified along the midline brainstem region in vivo.
Midline nuclei clustered in four groups appeared to be the raphe nuclei and could be clearly visualized; specifically, we identified the groups as the dorsal raphe, raphe reticularis centralis superior, raphe pontis, and raphe magnus group.
FDG imaging of the midline raphe nuclei in vivo could potentially be an important tool for investigating brain diseases as well as conducting functional brain studies in the context of sleep disorders, depression, and neurodegenerative disease.
► The brainstem was imaged using high-resolution PET–MRI fusion system. ► Midline raphe-like nuclei were measured by FDG PET image. ► Anatomical landmarks provided by MRI helped identification of the nuclei. ► Finding of the raphe can be useful for studying serotoninergic function.</description><subject>Brain research</subject><subject>Brain stem</subject><subject>Brainstem</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Fusion imaging</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Ligands</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Metabolic Clearance Rate</subject><subject>Metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>PET–MRI</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Raphe nuclei</subject><subject>Raphe Nuclei - diagnostic imaging</subject><subject>Raphe Nuclei - metabolism</subject><subject>Raphe Nuclei - pathology</subject><subject>Serotonin</subject><subject>Studies</subject><subject>Subtraction Technique</subject><subject>Tissue Distribution</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1u1DAQgC0Eou3CKyBLHDglzOTXPkJV2kpFIFTOlu1MileJvdhJpd76DrwhT4KXLSBx6cEaa_yNx-OPMY5QImD3dlt6WmNws76hsgLEEmQJdfeEHSPItpBtXz3d79u6EIjyiJ2ktAUAiY14zo4qlF0tKzhmw_m02pCIz7RoEyaXZh5GvnzLGTdMzhP3q53I8ah3Oen87zMTtfNpoQybRPGWBm7u-Oez65_3Pz5-ueTjmlzwfP9A529esGejnhK9fIgb9vXD2fXpRXH16fzy9N1VYRspl6JuOj12AmWNo0VpEA1oghF6raHRWAndVyQFWWw7TYKM6DupB-hta2Tb1Rv25nDvLobvK6VFzS5ZmibtKaxJSWwbWbUNPk6C6Ju6yWvDXv9HbsMafR5DoaibGiCHTIkDZWNIKdKodjEPH-8UgtorU1v1T5naK1MgVVaWS189NFjNTMPfwj-OMvD-AFD-ultHUSXryFsaXCS7qCG4x7v8Ao0srP4</recordid><startdate>20120116</startdate><enddate>20120116</enddate><creator>Son, Young-Don</creator><creator>Cho, Zang-Hee</creator><creator>Kim, Hang-Keun</creator><creator>Choi, Eun-Jung</creator><creator>Lee, Sang-Yoon</creator><creator>Chi, Je-Geun</creator><creator>Park, Chan-Woong</creator><creator>Kim, Young-Bo</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20120116</creationdate><title>Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET–MRI fusion imaging</title><author>Son, Young-Don ; Cho, Zang-Hee ; Kim, Hang-Keun ; Choi, Eun-Jung ; Lee, Sang-Yoon ; Chi, Je-Geun ; Park, Chan-Woong ; Kim, Young-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-346af681931fc19b11b0ae0f07aa04a128a72e98ec156ae8eb8769ad07c5b9563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Brain research</topic><topic>Brain stem</topic><topic>Brainstem</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Young-Don</au><au>Cho, Zang-Hee</au><au>Kim, Hang-Keun</au><au>Choi, Eun-Jung</au><au>Lee, Sang-Yoon</au><au>Chi, Je-Geun</au><au>Park, Chan-Woong</au><au>Kim, Young-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET–MRI fusion imaging</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2012-01-16</date><risdate>2012</risdate><volume>59</volume><issue>2</issue><spage>1094</spage><epage>1097</epage><pages>1094-1097</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging.
Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) were performed in seven healthy subjects using a new PET–MRI, which consists of a high-resolution research tomograph (HRRT) PET and 7.0T-MRI. Glucose metabolism of raphe nuclei was semiquantitatively measured and identified along the midline brainstem region in vivo.
Midline nuclei clustered in four groups appeared to be the raphe nuclei and could be clearly visualized; specifically, we identified the groups as the dorsal raphe, raphe reticularis centralis superior, raphe pontis, and raphe magnus group.
FDG imaging of the midline raphe nuclei in vivo could potentially be an important tool for investigating brain diseases as well as conducting functional brain studies in the context of sleep disorders, depression, and neurodegenerative disease.
► The brainstem was imaged using high-resolution PET–MRI fusion system. ► Midline raphe-like nuclei were measured by FDG PET image. ► Anatomical landmarks provided by MRI helped identification of the nuclei. ► Finding of the raphe can be useful for studying serotoninergic function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21963920</pmid><doi>10.1016/j.neuroimage.2011.09.036</doi><tpages>4</tpages></addata></record> |
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| subjects | Brain research Brain stem Brainstem Female Fluorodeoxyglucose F18 - pharmacokinetics Fusion imaging Glucose - metabolism Humans Ligands Magnetic Resonance Imaging - methods Male Medical imaging Metabolic Clearance Rate Metabolism NMR Nuclear magnetic resonance PET–MRI Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Raphe nuclei Raphe Nuclei - diagnostic imaging Raphe Nuclei - metabolism Raphe Nuclei - pathology Serotonin Studies Subtraction Technique Tissue Distribution Young Adult |
| title | Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET–MRI fusion imaging |
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