Oriental HLA-A11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A11:90 allele
Summary We report here an HLA‐A allele, A*11:90, found in a Taiwanese cord blood sample using DNA sequence‐based typing (SBT) protocol after observing an anomalous reaction pattern in a sequence‐specific oligonucleotide (SSO) typing exercise. The sequence of A*11:90 is identical to A*11:01:01, the m...
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| Veröffentlicht in: | International journal of immunogenetics 2011-12, Vol.38 (6), p.543-546 |
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| container_title | International journal of immunogenetics |
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| creator | Yang, K. L. Lee, S. K. Lin, C. C. Jiang, S. Chiu, H. M. Lin, S. Chen, Y. C. Jian, Y. F. Yang, S. Y. Yang, Y. B. Chen, S. B. Shyr, M. H. Lin, C. L. Lin, P. Y. |
| description | Summary
We report here an HLA‐A allele, A*11:90, found in a Taiwanese cord blood sample using DNA sequence‐based typing (SBT) protocol after observing an anomalous reaction pattern in a sequence‐specific oligonucleotide (SSO) typing exercise. The sequence of A*11:90 is identical to A*11:01:01, the most predominant A*11 variant in Taiwanese, in exon 2 but differs from A*11:01:01 in exon 3 by two nucleotide substitutions at codon 163 (c.487C>G and c.488G>A), resulting R163E. In comparison with the sequence of A*11:02:01, the second most predominant subtype of A*11 in Taiwanese A*11:90 has one nucleotide difference at codon 19 (c.55A>G) in exon 2 resulting K19E and two nucleotides variations at codon 163 (c.487C>G and c.488G>A) in exon 3 resulting R163E. HLA‐A*11:90‐B*40:02‐DRB1*11:01 is the deduced probable HLA haplotype in association with A*11:90. The generation of A*11:90 is thought to involve a DNA recombination event between alleles A*11:01:01 and A*80:01 where A*80:01 donated a fragment of the DNA sequence (from n.t. 487 to n.t. 497) to the recipient sequence of A*11:01:01. |
| doi_str_mv | 10.1111/j.1744-313X.2011.01031.x |
| format | Article |
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We report here an HLA‐A allele, A*11:90, found in a Taiwanese cord blood sample using DNA sequence‐based typing (SBT) protocol after observing an anomalous reaction pattern in a sequence‐specific oligonucleotide (SSO) typing exercise. The sequence of A*11:90 is identical to A*11:01:01, the most predominant A*11 variant in Taiwanese, in exon 2 but differs from A*11:01:01 in exon 3 by two nucleotide substitutions at codon 163 (c.487C>G and c.488G>A), resulting R163E. In comparison with the sequence of A*11:02:01, the second most predominant subtype of A*11 in Taiwanese A*11:90 has one nucleotide difference at codon 19 (c.55A>G) in exon 2 resulting K19E and two nucleotides variations at codon 163 (c.487C>G and c.488G>A) in exon 3 resulting R163E. HLA‐A*11:90‐B*40:02‐DRB1*11:01 is the deduced probable HLA haplotype in association with A*11:90. The generation of A*11:90 is thought to involve a DNA recombination event between alleles A*11:01:01 and A*80:01 where A*80:01 donated a fragment of the DNA sequence (from n.t. 487 to n.t. 497) to the recipient sequence of A*11:01:01.</description><identifier>ISSN: 1744-3121</identifier><identifier>EISSN: 1744-313X</identifier><identifier>DOI: 10.1111/j.1744-313X.2011.01031.x</identifier><identifier>PMID: 21806781</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alleles ; Amino Acid Sequence ; Asian Continental Ancestry Group - genetics ; Base Sequence ; Codons ; Cord blood ; Exons ; Fetal Blood - immunology ; Fetal Blood - metabolism ; Genetic Association Studies ; Haplotypes ; Haplotypes - genetics ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA-A Antigens - chemistry ; HLA-A Antigens - genetics ; Humans ; Molecular Sequence Data ; Nucleotide sequence ; Oligonucleotides ; Physical training ; Recombination ; Sequence Homology, Amino Acid ; Taiwan ; Tissue typing</subject><ispartof>International journal of immunogenetics, 2011-12, Vol.38 (6), p.543-546</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4381-2e8cd0becff4dc0d0011ee2202041fbc190dfadb4299c3c568f4a8290b34580c3</citedby><cites>FETCH-LOGICAL-c4381-2e8cd0becff4dc0d0011ee2202041fbc190dfadb4299c3c568f4a8290b34580c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1744-313X.2011.01031.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1744-313X.2011.01031.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21806781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, K. L.</creatorcontrib><creatorcontrib>Lee, S. K.</creatorcontrib><creatorcontrib>Lin, C. C.</creatorcontrib><creatorcontrib>Jiang, S.</creatorcontrib><creatorcontrib>Chiu, H. M.</creatorcontrib><creatorcontrib>Lin, S.</creatorcontrib><creatorcontrib>Chen, Y. C.</creatorcontrib><creatorcontrib>Jian, Y. F.</creatorcontrib><creatorcontrib>Yang, S. Y.</creatorcontrib><creatorcontrib>Yang, Y. B.</creatorcontrib><creatorcontrib>Chen, S. B.</creatorcontrib><creatorcontrib>Shyr, M. H.</creatorcontrib><creatorcontrib>Lin, C. L.</creatorcontrib><creatorcontrib>Lin, P. Y.</creatorcontrib><title>Oriental HLA-A11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A11:90 allele</title><title>International journal of immunogenetics</title><addtitle>Int J Immunogenet</addtitle><description>Summary
We report here an HLA‐A allele, A*11:90, found in a Taiwanese cord blood sample using DNA sequence‐based typing (SBT) protocol after observing an anomalous reaction pattern in a sequence‐specific oligonucleotide (SSO) typing exercise. The sequence of A*11:90 is identical to A*11:01:01, the most predominant A*11 variant in Taiwanese, in exon 2 but differs from A*11:01:01 in exon 3 by two nucleotide substitutions at codon 163 (c.487C>G and c.488G>A), resulting R163E. In comparison with the sequence of A*11:02:01, the second most predominant subtype of A*11 in Taiwanese A*11:90 has one nucleotide difference at codon 19 (c.55A>G) in exon 2 resulting K19E and two nucleotides variations at codon 163 (c.487C>G and c.488G>A) in exon 3 resulting R163E. HLA‐A*11:90‐B*40:02‐DRB1*11:01 is the deduced probable HLA haplotype in association with A*11:90. The generation of A*11:90 is thought to involve a DNA recombination event between alleles A*11:01:01 and A*80:01 where A*80:01 donated a fragment of the DNA sequence (from n.t. 487 to n.t. 497) to the recipient sequence of A*11:01:01.</description><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Base Sequence</subject><subject>Codons</subject><subject>Cord blood</subject><subject>Exons</subject><subject>Fetal Blood - immunology</subject><subject>Fetal Blood - metabolism</subject><subject>Genetic Association Studies</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Testing</subject><subject>HLA-A Antigens - chemistry</subject><subject>HLA-A Antigens - genetics</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Nucleotide sequence</subject><subject>Oligonucleotides</subject><subject>Physical training</subject><subject>Recombination</subject><subject>Sequence Homology, Amino Acid</subject><subject>Taiwan</subject><subject>Tissue typing</subject><issn>1744-3121</issn><issn>1744-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGP0zAQhSMEYpeFv4B845QwYzttgsShqpZuUcVelmVvlmNPVBc3zsap2v57km3pFeYyI_l9z5p5ScIQMhzq8ybDqZSpQPGUcUDMAEFgdniVXF8eXl9mjlfJuxg3AGIiJbxNrjgWMJkWeJ0833eOml57dreapTPELyUwSz2ZnixzDdPsQbu9bigSM6GzrPIhWBb1tvXEdGNZvya21q0P_bGlFyTGYJzuXWjY3vVrdrbV3pOn98mbWvtIH879Jvn57fZhfpeu7hfL-WyVGikKTDkVxkJFpq6lNWBhWJOIc-Agsa4MlmBrbSvJy9IIk0-KWuqCl1AJmRdgxE3y6eTbduF5R7FXWxcNeT_sEnZRlZjLkssy_7cS-HAuhFFZnJSmCzF2VKu2c1vdHRWCGpNRGzUeXY0BqDEZ9ZKMOgzox_Mnu2pL9gL-jWIQfD0J9s7T8b-N1fL7cpwGPj3xLvZ0uPC6-60mUzHN1a8fC_X4WBaLp_lcgfgD_RWp3A</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Yang, K. L.</creator><creator>Lee, S. K.</creator><creator>Lin, C. C.</creator><creator>Jiang, S.</creator><creator>Chiu, H. M.</creator><creator>Lin, S.</creator><creator>Chen, Y. C.</creator><creator>Jian, Y. F.</creator><creator>Yang, S. Y.</creator><creator>Yang, Y. B.</creator><creator>Chen, S. B.</creator><creator>Shyr, M. H.</creator><creator>Lin, C. L.</creator><creator>Lin, P. Y.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201112</creationdate><title>Oriental HLA-A11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A11:90 allele</title><author>Yang, K. L. ; Lee, S. K. ; Lin, C. C. ; Jiang, S. ; Chiu, H. M. ; Lin, S. ; Chen, Y. C. ; Jian, Y. F. ; Yang, S. Y. ; Yang, Y. B. ; Chen, S. B. ; Shyr, M. H. ; Lin, C. L. ; Lin, P. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4381-2e8cd0becff4dc0d0011ee2202041fbc190dfadb4299c3c568f4a8290b34580c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alleles</topic><topic>Amino Acid Sequence</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Base Sequence</topic><topic>Codons</topic><topic>Cord blood</topic><topic>Exons</topic><topic>Fetal Blood - immunology</topic><topic>Fetal Blood - metabolism</topic><topic>Genetic Association Studies</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Testing</topic><topic>HLA-A Antigens - chemistry</topic><topic>HLA-A Antigens - genetics</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Nucleotide sequence</topic><topic>Oligonucleotides</topic><topic>Physical training</topic><topic>Recombination</topic><topic>Sequence Homology, Amino Acid</topic><topic>Taiwan</topic><topic>Tissue typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, K. L.</creatorcontrib><creatorcontrib>Lee, S. K.</creatorcontrib><creatorcontrib>Lin, C. C.</creatorcontrib><creatorcontrib>Jiang, S.</creatorcontrib><creatorcontrib>Chiu, H. M.</creatorcontrib><creatorcontrib>Lin, S.</creatorcontrib><creatorcontrib>Chen, Y. C.</creatorcontrib><creatorcontrib>Jian, Y. F.</creatorcontrib><creatorcontrib>Yang, S. Y.</creatorcontrib><creatorcontrib>Yang, Y. B.</creatorcontrib><creatorcontrib>Chen, S. B.</creatorcontrib><creatorcontrib>Shyr, M. H.</creatorcontrib><creatorcontrib>Lin, C. L.</creatorcontrib><creatorcontrib>Lin, P. Y.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>International journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, K. L.</au><au>Lee, S. K.</au><au>Lin, C. C.</au><au>Jiang, S.</au><au>Chiu, H. M.</au><au>Lin, S.</au><au>Chen, Y. C.</au><au>Jian, Y. F.</au><au>Yang, S. Y.</au><au>Yang, Y. B.</au><au>Chen, S. B.</au><au>Shyr, M. H.</au><au>Lin, C. L.</au><au>Lin, P. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oriental HLA-A11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A11:90 allele</atitle><jtitle>International journal of immunogenetics</jtitle><addtitle>Int J Immunogenet</addtitle><date>2011-12</date><risdate>2011</risdate><volume>38</volume><issue>6</issue><spage>543</spage><epage>546</epage><pages>543-546</pages><issn>1744-3121</issn><eissn>1744-313X</eissn><abstract>Summary
We report here an HLA‐A allele, A*11:90, found in a Taiwanese cord blood sample using DNA sequence‐based typing (SBT) protocol after observing an anomalous reaction pattern in a sequence‐specific oligonucleotide (SSO) typing exercise. The sequence of A*11:90 is identical to A*11:01:01, the most predominant A*11 variant in Taiwanese, in exon 2 but differs from A*11:01:01 in exon 3 by two nucleotide substitutions at codon 163 (c.487C>G and c.488G>A), resulting R163E. In comparison with the sequence of A*11:02:01, the second most predominant subtype of A*11 in Taiwanese A*11:90 has one nucleotide difference at codon 19 (c.55A>G) in exon 2 resulting K19E and two nucleotides variations at codon 163 (c.487C>G and c.488G>A) in exon 3 resulting R163E. HLA‐A*11:90‐B*40:02‐DRB1*11:01 is the deduced probable HLA haplotype in association with A*11:90. The generation of A*11:90 is thought to involve a DNA recombination event between alleles A*11:01:01 and A*80:01 where A*80:01 donated a fragment of the DNA sequence (from n.t. 487 to n.t. 497) to the recipient sequence of A*11:01:01.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21806781</pmid><doi>10.1111/j.1744-313X.2011.01031.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Alleles Amino Acid Sequence Asian Continental Ancestry Group - genetics Base Sequence Codons Cord blood Exons Fetal Blood - immunology Fetal Blood - metabolism Genetic Association Studies Haplotypes Haplotypes - genetics Histocompatibility antigen HLA Histocompatibility Testing HLA-A Antigens - chemistry HLA-A Antigens - genetics Humans Molecular Sequence Data Nucleotide sequence Oligonucleotides Physical training Recombination Sequence Homology, Amino Acid Taiwan Tissue typing |
| title | Oriental HLA-A11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A11:90 allele |
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