Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy

Abstract Protein aggregation is the major pathological hallmark seen in neurodegenerative disorders such as Parkinson's disease (PD). Alpha-synuclein (αS) is the main component of protein aggregates that form Lewy bodies (LBs) in PD and dementia with LBs. There have been several attempts to int...

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Veröffentlicht in:	Neuroscience 2011-12, Vol.199, p.303-317
Hauptverfasser:	Sultana, Z, Paleologou, K.E, Al-Mansoori, K.M, Ardah, M.T, Singh, N, Usmani, S, Jiao, H, Martin, F.L, Bharath, M.M.S, Vali, S, El-Agnaf, O.M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Biological and medical sciences Blotting, Western Cell Line, Tumor Comet Assay Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dopaminergic neuron Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Fundamental and applied biological sciences. Psychology Humans in silico Lewy Bodies - metabolism Lewy Bodies - pathology Medical sciences Models, Neurological Neurology oligomers Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease protein aggregation User-Computer Interface Vertebrates: nervous system and sense organs α-synuclein
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