Biomechanical responses of different rat tendons to nandrolone decanoate and load exercise

Androgenic‐anabolic steroids (AAS) have been associated with an increased incidence of tendon rupture. The aim of this study was to compare the biomechanical properties of the rat calcaneal tendon (CT), superficial flexor tendon (SFT), and deep flexor tendon (DFT), and to determine the effect of jum...

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Veröffentlicht in:Scandinavian journal of medicine & science in sports 2011-12, Vol.21 (6), p.e91-e99
Hauptverfasser: Marqueti, R. C., Prestes, J., Wang, C. C., Ramos, O. H. P., Perez, S. E. A., Nakagaki, W. R., Carvalho, H. F., Selistre-de-Araujo, H. S.
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container_end_page e99
container_issue 6
container_start_page e91
container_title Scandinavian journal of medicine & science in sports
container_volume 21
creator Marqueti, R. C.
Prestes, J.
Wang, C. C.
Ramos, O. H. P.
Perez, S. E. A.
Nakagaki, W. R.
Carvalho, H. F.
Selistre-de-Araujo, H. S.
description Androgenic‐anabolic steroids (AAS) have been associated with an increased incidence of tendon rupture. The aim of this study was to compare the biomechanical properties of the rat calcaneal tendon (CT), superficial flexor tendon (SFT), and deep flexor tendon (DFT), and to determine the effect of jump training in association with AAS. Animals were separated into four groups: sedentary, trained, AAS‐treated sedentary rats (AAS), and AAS‐treated and trained animals. Mechanical testing showed that the CT differed from the DFT and SFT, which showed similar mechanical properties. Jump caused the CT to exhibit an extended toe region, an increased resistance to tensional load, and a decreased elastic modulus, characteristics of an elastic tendon capable of storing energy. AAS caused the tendons to be less compliant, and the effects were reinforced by simultaneous training. The DFT was the most affected by training, AAS, and the interaction of both, likely because of its involvement in the toe‐off step of jumping, which we suggest is related to the rapid transmission of force as opposed to energy storage. In conclusion, tendons are differently adapted to exercise, but responded equally to AAS, showing reduced flexibility, which is suggested to increase the risk of tendon rupture in AAS consumers.
doi_str_mv 10.1111/j.1600-0838.2010.01162.x
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C. ; Prestes, J. ; Wang, C. C. ; Ramos, O. H. P. ; Perez, S. E. A. ; Nakagaki, W. R. ; Carvalho, H. F. ; Selistre-de-Araujo, H. S.</creator><creatorcontrib>Marqueti, R. C. ; Prestes, J. ; Wang, C. C. ; Ramos, O. H. P. ; Perez, S. E. A. ; Nakagaki, W. R. ; Carvalho, H. F. ; Selistre-de-Araujo, H. S.</creatorcontrib><description>Androgenic‐anabolic steroids (AAS) have been associated with an increased incidence of tendon rupture. The aim of this study was to compare the biomechanical properties of the rat calcaneal tendon (CT), superficial flexor tendon (SFT), and deep flexor tendon (DFT), and to determine the effect of jump training in association with AAS. Animals were separated into four groups: sedentary, trained, AAS‐treated sedentary rats (AAS), and AAS‐treated and trained animals. Mechanical testing showed that the CT differed from the DFT and SFT, which showed similar mechanical properties. 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C.</au><au>Prestes, J.</au><au>Wang, C. C.</au><au>Ramos, O. H. P.</au><au>Perez, S. E. A.</au><au>Nakagaki, W. R.</au><au>Carvalho, H. F.</au><au>Selistre-de-Araujo, H. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical responses of different rat tendons to nandrolone decanoate and load exercise</atitle><jtitle>Scandinavian journal of medicine &amp; science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2011-12</date><risdate>2011</risdate><volume>21</volume><issue>6</issue><spage>e91</spage><epage>e99</epage><pages>e91-e99</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>Androgenic‐anabolic steroids (AAS) have been associated with an increased incidence of tendon rupture. The aim of this study was to compare the biomechanical properties of the rat calcaneal tendon (CT), superficial flexor tendon (SFT), and deep flexor tendon (DFT), and to determine the effect of jump training in association with AAS. 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In conclusion, tendons are differently adapted to exercise, but responded equally to AAS, showing reduced flexibility, which is suggested to increase the risk of tendon rupture in AAS consumers.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20673248</pmid><doi>10.1111/j.1600-0838.2010.01162.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Anabolic Agents - administration & dosage
Anabolic Agents - pharmacology
anabolic-androgenic steroids
Animals
Biomechanical Phenomena - drug effects
biomechanical test
Biomechanics
Exercise
Flexibility
Hernia
Jumping
Male
material properties
Nandrolone - administration & dosage
Nandrolone - analogs & derivatives
Nandrolone - pharmacology
Physical Conditioning, Animal
Random Allocation
Rats
Rats, Wistar
Rodents
Sport science
Steroids
Tendons
Tendons - drug effects
Weight-Bearing - physiology
Work load
title Biomechanical responses of different rat tendons to nandrolone decanoate and load exercise
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