A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development

Transporters are essential in thyroid hormone metabolism. Thyroxine (T4) is transported by solute carrier organic anion transporter 1c1 (SLCO1C1, OATP14) into the adult brain, where T4 is converted to 3,5,3′‐triiodothyronine (T3). In adults, SLCO1C1 expression is found in two brain barrier structure...

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Veröffentlicht in:	Journal of neuroendocrinology 2011-12, Vol.23 (12), p.1194-1203
Hauptverfasser:	Lang, M.-F., Salinin, S., Ridder, D. A., Kleesiek, J., Hroudova, J., Berger, S., Schütz, G., Schwaninger, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Animals Biological and medical sciences Brain - embryology Brain - growth & development Brain - metabolism brain development Cells, Cultured Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gene Transfer Techniques hypothyroidism Hypothyroidism - genetics Hypothyroidism - metabolism Integrases - genetics Integrases - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Non tumoral diseases. Target tissue resistance. Benign neoplasms Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Pregnancy solute carrier organic anion transporter 1c1 thyroid hormones Thyroid. Thyroid axis (diseases) thyroxine transporter Thyroxine-Binding Proteins - genetics Thyroxine-Binding Proteins - metabolism Tissue Distribution Vertebrates: endocrinology
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