The vascular origin of hematopoietic cells
More than a century ago, several embryologists described sites of hematopoietic activity in the vascular wall of mid-gestation vertebrate embryos, and postulated the transient existence of a blood generating endothelium during ontogeny. This hypothesis gained significant attention in the 1970s when...
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| Veröffentlicht in: | Developmental biology 2012-02, Vol.362 (1), p.1-10 |
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| creator | Adamo, Luigi García-Cardeña, Guillermo |
| description | More than a century ago, several embryologists described sites of hematopoietic activity in the vascular wall of mid-gestation vertebrate embryos, and postulated the transient existence of a blood generating endothelium during ontogeny. This hypothesis gained significant attention in the 1970s when orthotopic transplantation experiments between quail and chick embryos revealed specific vascular areas as the site of the origin of definitive hematopoiesis. However, the vascular origin of hematopoietic precursors remained elusive and controversial for decades. Only recently, multiple experimental approaches have clearly documented that during vertebrate development definitive hematopoietic precursors arise from a subset of vascular endothelial cells. Interestingly, this differentiation is promoted by the intravascular fluid mechanical forces generated by the establishment of blood flow upon the initiation of heartbeat, and it is therefore connected with cardiovascular development in several critical aspects. In this review we present our current understanding of the relationship between vascular and definitive hematopoietic development through an historical analysis of the scientific evidence produced in this area of investigation. |
| doi_str_mv | 10.1016/j.ydbio.2011.09.008 |
| format | Article |
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This hypothesis gained significant attention in the 1970s when orthotopic transplantation experiments between quail and chick embryos revealed specific vascular areas as the site of the origin of definitive hematopoiesis. However, the vascular origin of hematopoietic precursors remained elusive and controversial for decades. Only recently, multiple experimental approaches have clearly documented that during vertebrate development definitive hematopoietic precursors arise from a subset of vascular endothelial cells. Interestingly, this differentiation is promoted by the intravascular fluid mechanical forces generated by the establishment of blood flow upon the initiation of heartbeat, and it is therefore connected with cardiovascular development in several critical aspects. 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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Aorta-Gonad-Mesonephros (AGM) blood blood flow Cell Differentiation - physiology Chick Embryo chickens chicks Chimera embryo (animal) endothelial cells Endothelial Cells - cytology endothelium Hematopoiesis Hematopoiesis - physiology hematopoietic stem cells Hematopoietic Stem Cells - cytology Hemogenic endothelium Hemorheology Hydrodynamics Models, Biological ontogeny Para-Aortic-Splanchnopleura (PSp) Quail quails Shear Strength Shear stress |
| title | The vascular origin of hematopoietic cells |
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